Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kelly Chatman"'
Autor:
Kelvin J. Y. Wu, Giambattista Testolin, Alexander S. Mankin, Daniel W. Terwilliger, Amarnath Pisipati, Katherine J. Silvestre, Andrew G. Myers, Matthew J. Mitcheltree, Kelly Chatman, Egor A Syroegin, Jeremy D. Mason, Richard Porter Ladley, Aditya R. Pote, Yury S. Polikanov, Dorota Klepacki
Publikováno v:
Nature. 599(7885)
The dearth of new medicines effective against antibiotic-resistant bacteria presents a growing global public health concern1. For more than five decades, the search for new antibiotics has relied heavily on the chemical modification of natural produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358e9add280ea59a94a0a3ef98030545
https://pubmed.ncbi.nlm.nih.gov/34754106
https://pubmed.ncbi.nlm.nih.gov/34754106
Autor:
Matthew Mitcheltree, Amarnath Pisipati, Egor A. Syroegin, Katherine J. Silvestre, Dorota Klepacki, Jeremy Mason, Daniel W. Terwilliger, Giambattista Testolin, Aditya R. Pote, Kelvin J. Y. Wu, Richard Porter Ladley, Kelly Chatman, Alexander S. Mankin, Yury S. Polikanov, Andrew G. Myers
The dearth of new medicines effective against antibiotic-resistant bacteria presents a growing global public health concern. For more than five decades, the search for new antibiotics has relied heavily upon the chemical modification of natural produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f22f369c6e889625ce58f5d324896d3
https://doi.org/10.26434/chemrxiv.14331407
https://doi.org/10.26434/chemrxiv.14331407
Publikováno v:
Leading with the Spirit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1f64fb559cdc8ec9d2f7a9eb25b34f4
https://doi.org/10.2307/j.ctvzcz2z2.8
https://doi.org/10.2307/j.ctvzcz2z2.8
Autor:
Talia Golan, Alexander Brandis, Judith Sandbank, Zachary A. Cooper, Matteo Ligorio, Sangeeta N. Bhatia, Jonathan Livny, Noam Shental, Jason B. Fleming, Sarah P. Thayer, Alexandre Reuben, Tal Danino, Candice Gurbatri, Sunia A. Trauger, Anna Mandinova, Vancheswaran Gopalakrishnan, Iris Barshack, Mark W. Hurd, Dirk Gevers, Deborah Nejman, Matthew Skalak, Jennifer A. Wargo, Carrie M. Mosher, Wendy S. Garrett, Jeffrey Bu, Kelly Chatman, Stephen Johnston, Todd R. Golub, Michal Barzily-Rokni, Nancy Gavert, Michael P. Kim, Cristina R. Ferrone, Keith T. Flaherty, Dennie T. Frederick, Curtis Huttenhower, Roi Avraham, Ravid Straussman, Matthew H.G. Katz, Yaara Zwang, David Smith, Monia Michaud, Kevin Shee, Oliver Jonas, Leore T. Geller, Anirban Maitra, Christoph A. Thaiss, Garold Fuks
Publikováno v:
Science. 357:1156-1160
Growing evidence suggests that microbes can influence the efficacy of cancer therapies. By studying colon cancer models, we found that bacteria can metabolize the chemotherapeutic drug gemcitabine (2′,2′-difluorodeoxycytidine) into its inactive f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73de7a5f35b9daf75ea6546a5eaf0a29
https://doi.org/10.1126/science.aah5043
https://doi.org/10.1126/science.aah5043
Autor:
Sunia A. Trauger, Lauren S Weiner, Aaron M. Cypess, Gerald M. Kolodny, Kelly Chatman, Elisa F. Elia, Skyler H. Kessler, Peter A. Kahn, Jeffrey English, Alessandro Doria, Carla Roberts-Toler
Publikováno v:
Cell Metabolism. 21:33-38
Summary Increasing energy expenditure through activation of endogenous brown adipose tissue (BAT) is a potential approach to treat obesity and diabetes. The class of β3-adrenergic receptor (AR) agonists stimulates rodent BAT, but this activity has n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470ebe2de27248909c62c1a0d150db65
https://doi.org/10.1016/j.cmet.2014.12.009
https://doi.org/10.1016/j.cmet.2014.12.009
Autor:
Monique Vallee, Robert Purdy, Lee R. Hagey, Gary Siuzdak, Kelly Chatman, Thomas Hollenbeck, Friedbert Weiss
Publikováno v:
Analytical Chemistry. 71:2358-2363
Nanoelectrospray ionization (nanoESI) mass spectrometry was performed on naturally occurring steroid sulfates and unconjugated steroids derivatized to their sulfate esters using precursor ion monitoring. Initially, an extraction method was developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd17369dce28e443658d9912fbe2d688
https://doi.org/10.1021/ac9806411
https://doi.org/10.1021/ac9806411
An Automated MALDI Mass Spectrometry Approach for Optimizing Cyclosporin Extraction and Quantitation
Publikováno v:
Analytical Chemistry. 69:3767-3771
A combinatorial extraction method and an automated matrix-assisted laser desorption/ionization (MALDI) mass spectrometry procedure were used to improve the clinical analysis of the immunosuppressant drug cyclosporin A. Cyclosporin extracts from whole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9aa60fedf49359fbfcc24ca34c2a446
https://doi.org/10.1021/ac970276y
https://doi.org/10.1021/ac970276y
Autor:
Henry J. Haiser, David B. Gootenberg, Gopal Sirasani, Kelly Chatman, Peter J. Turnbaugh, Emily P. Balskus
Publikováno v:
Science (New York, N.Y.), vol 341, iss 6143
Digoxin Dangers A proportion of patients treated with digoxin, a cardiac glycoside used to treat heart function abnormalities, generate the inactive metabolite, dihydrodigoxin, resulting in poor efficacy. Haiser et al. (p. 295 ) examined a potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf4dc33995ed69d4c3a895c66e050ef
https://escholarship.org/uc/item/5v95p9g0
https://escholarship.org/uc/item/5v95p9g0
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2863-2868
The development of rapid, simple and accurate methods for characterizing and insuring the integrity of oligonucleotides is important for the development of therapeutic and diagnostic products. This study was performed to determine the utility of high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae6c856443051a051671bb56fa1c439c
https://doi.org/10.1016/0960-894x(95)00499-j
https://doi.org/10.1016/0960-894x(95)00499-j
Autor:
Zhong-Li ZhengP, Federico C. A. Gaeta, Chi-Huey Wong, Yoshitaka Ichikawa, John Y. Rhamphal, Kelly Chatman, Kyriacos C. Nicolaou, Gary Siuzdak
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2863-2866
The Ca 2+ binding properties of the cell-surface carbohydrate sialyl Lewis x, SLe x , and its 2-, 3-, and 4- deoxygenated-fucose analogs, were examined by pneumatically-assisted electrospray (ion spray) mass spectrometry. Computer-assisted modeling a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cb0260c18bf6688f3fb07242feff411
https://doi.org/10.1016/s0960-894x(01)80829-5
https://doi.org/10.1016/s0960-894x(01)80829-5