Exploring the pharmacological potential of promiscuous host-defense peptides: from natural screenings to biotechnological applications

Autor: Osmar Nascimento Silva, Kelly C.L. Mulder, Aulus AD Barbosa, Anselmo J Otero-Gonzalez, Carlos eLopez-Abarrategui, Simoni C Dias, Taia MB Rezende, Octavio Luiz Franco

Publikováno v: Frontiers in Microbiology, Vol 2 (2011)

In the last few years, the number of bacteria with enhanced resistance to conventional antibiotics has dramatically increased. Most of such bacteria belong to regular microbial flora, becoming a real challenge, especially for immune-depressed patient

Externí odkaz: https://doaj.org/article/185091dfb8a945a7856ef1ea60e96d8b

Novel homologous lactate transporter improves l-lactic acid production from glycerol in recombinant strains of Pichia pastoris

Autor: Beatriz Simas Magalhães, Nadiele Tamires Moreira Melo, Gisele Menino, Virgilio H. de Castro, Nádia Skorupa Parachin, Lucas Silva Carvalho, Eduardo Mulinari, Gustavo H. Goldman, Thaila Fernanda dos Reis, Pollyne Borborema Almeida de Lima, Kelly C.L. Mulder

Publikováno v: Repositório Institucional da UnB
Universidade de Brasília (UnB)
instacron:UNB
Microbial Cell Factories
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Background: Crude glycerol is the main byproduct of the biodiesel industry. Although it can have different applications, its purification is costly. Therefore, in this study a biotechnological route has been proposed for further utilization of crude

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b7653f0172331ba9e31ef3dc3d22c6
https://doi.org/10.1186/s12934-016-0557-9

Effect of Pyruvate Decarboxylase Knockout on Product Distribution Using Pichia pastoris (Komagataella phaffii) Engineered for Lactic Acid Production

Autor: Nadiele T M Melo, Gisele Menino, André Moraes Nicola, Kelly C.L. Mulder, Eduardo Mulinari, Nádia Skorupa Parachin, Lucas Silva Carvalho

Publikováno v: Bioengineering; Volume 5; Issue 1; Pages: 17
Bioengineering
Bioengineering, Vol 5, Iss 1, p 17 (2018)

Lactic acid is the monomer unit of the bioplastic poly-lactic acid (PLA). One candidate organism for lactic acid production is Pichia pastoris, a yeast widely used for heterologous protein production. Nevertheless, this yeast has a poor fermentative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80376e7f1d0f49fe2609a1d4b21a72c
https://doi.org/10.3390/bioengineering5010017

Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides

Autor: Simoni Campos Dias, Octavio L. Franco, Kelly C.L. Mulder, Loiane Alves de Lima, Vívian de Jesus Miranda

Publikováno v: Frontiers in Microbiology
Frontiers in Microbiology, Vol 4 (2013)

Cationic antimicrobial peptides (AMPs) and host defense peptides (HDPs) show vast potential as peptide-based drugs. Great effort has been made in order to exploit their mechanisms of action, aiming to identify their targets as well as to enhance thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596b7eca5e64459dc2fda75e6bfd60c6
https://doi.org/10.3389/fmicb.2013.00321

Production of a modified peptide clavanin in Pichia pastoris: cloning, expression, purification and in vitro activities

Autor: Fábio Correa Carneiro, Octavio L. Franco, Priscilla Santos Aguiar, Simoni Campos Dias, Nádia Skorupa Parachin, Kelly C.L. Mulder, Loiane Alves de Lima

Publikováno v: AMB Express

Antimicrobial peptides are one of the most promising peptide-based drugs due to their enormous potential as novel biopharmaceuticals in both human and animal industries. In order to develop strategies to over produce such molecules, heterologous prod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39895e4f58c04a7f96df77d7ebeaf77