Výsledky vyhledávání - "Kelly C. Higa"

Akademický článek

Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis

Autor: Curtis J. Henry, Travis Nemkov, Matias Casás-Selves, Ganna Bilousova, Vadym Zaberezhnyy, Kelly C. Higa, Natalie J. Serkova, Kirk C. Hansen, Angelo D’Alessandro, James DeGregori

Publikováno v: Haematologica, Vol 102, Iss 12 (2017)

While dietary folate deficiency is associated with increased risk for birth defects and other diseases, evidence suggests that supplementation with folic acid can contribute to predisposition to some diseases, including immune dysfunction and cancer.

Externí odkaz: https://doaj.org/article/26c47b6e96c54214a4b6c1596c8e5c9d

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Noteworthy Cardiac Literature From 2021: Coronary Guideline Change Without New Data, Heart Transplant Donation After Cardiac Death, Covid Effects on Global Cardiac Surgery, and Attempt to Improve Dissection Remodeling

Autor: Jordan R. H. Hoffman, Kelly C. Higa, Yihan Lin, T. Brett Reece, Joseph C. Cleveland, Muhammad Aftab, Jessica Y. Rove

Publikováno v: Seminars in cardiothoracic and vascular anesthesia. 26(2)

Cardiac surgery continues to evolve. The last year has been notable for many reasons. The guidelines for coronary revascularization introduced significant discord. The pandemic continues to affect the care on a global scale. Advances in organ procure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4385d08cb11b71195f9397121c6c13f
https://pubmed.ncbi.nlm.nih.gov/35591803

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PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

Publikováno v: Journal of Experimental Medicine, 218 (6)
The Journal of Experimental Medicine

Hematopoietic stem cells (HSCs) are capable of entering the cell cycle to replenish the blood system in response to inflammatory cues; however, excessive proliferation in response to chronic inflammation can lead to either HSC attrition or expansion.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c5f0deeced3592614adf5e265ef87c
https://hdl.handle.net/20.500.11850/480362

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Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors

Autor: Etienne Danis, James DeGregori, Kelly C. Higa, Vadym Zaberezhnyy, Marco De Dominici, Daniel G. Tenen, James S. Chavez, Andrew Goodspeed, Eric M. Pietras, Jennifer L. Rabe

Publikováno v: The Journal of Experimental Medicine

Higa et al. show that chronic interleukin-1β exposure primes multipotent hematopoietic progenitor cells for myelopoiesis by upregulating myeloid differentiation programs and repressing stem gene programs in a Cebpa-dependent manner. Consequently, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595fcb49daa851ad452bb23dc17ad06d
http://europepmc.org/articles/PMC8094119

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Chronic Interleukin-1 exposure triggers selective expansion of Cebpa-deficient multipotent hematopoietic progenitors

Autor: Kelly C. Higa, Andrew Goodspeed, James S. Chavez, Vadym Zaberezhnyy, Jennifer L. Rabe, Daniel G. Tenen, Eric M. Pietras, James DeGregori

The early events that drive hematologic disorders like clonal hematopoiesis, myelodysplastic syndrome, myeloproliferative neoplasm, and acute myeloid leukemia are not well understood. Most studies focus on the cell-intrinsic genetic changes that occu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086fa09d344f8fb184a813b53bc5837b

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3061 – PU.1 ENFORCES QUIESCENCE AND LIMITS HEMATOPOIETIC STEM CELL EXPANSION DURING CHRONIC INFLAMMATION

Autor: Taylor S. Mills, Courtney J. Fleenor, Nouraiz Ahmed, Brett M. Stevens, Jennifer L. Rabe, James S. Chavez, Eric M. Pietras, Rachel L Gessner, Dirk Loeffler, Beau M Idler, Timm Schroeder, Kelly C. Higa, Craig T. Jordan, Hideaki Nakajima, James Hagman, Hyunmin Kim, Zhonghe Ke, James DeGregori

Publikováno v: Experimental Hematology. 88:S57

Hematopoietic stem cell (HSC) quiescence supports lifelong blood regeneration and guards against pre-leukemic clonal expansion. Acute exposure to the pro-inflammatory cytokine interleukin (IL)-1 drives myeloid cell production and HSC cell cycle entry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63045b16acbdc76ee7aead9868b8a5e1
https://doi.org/10.1016/j.exphem.2020.09.078

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INTERLEUKIN-1 RESTRICTS HSC PROLIFERATION VIA A PU.1-DEPENDENT MECHANISM

Autor: Dirk Loeffler, Kelly C. Higa, Jennifer L. Rabe, Eric M. Pietras, Claus Nerlov, James DeGregori, James S. Chavez, Timm Schroeder, Taylor S. Mills

Publikováno v: Experimental Hematology. 76:S82

Chronic inflammation is often associated with myeloid overproduction that can contribute to the pathogenesis of a range of inflammatory diseases. Paradoxically, despite ongoing inflammatory signaling, depletion of the HSC compartment is rarely observ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f181bbee54d68b80fd0a6a672abb599d
https://doi.org/10.1016/j.exphem.2019.06.420

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The RGSGR amino acid motif of the intercellular signalling protein, HetN, is required for patterning of heterocysts in Anabaena sp. strain PCC 7120

Autor: Kelly C. Higa, Orion S. Rivers, Douglas D. Risser, Sean M. Callahan, Patrick Videau, Sasa K. Tom, Ramya Rajagopalan

Publikováno v: Molecular Microbiology. 83:682-693

Nitrogen-fixing heterocysts are arranged in a periodic pattern on filaments of the cyanobacterium Anabaena sp. strain PCC 7120 under conditions of limiting combined nitrogen. Patterning requires two inhibitors of heterocyst differentiation, PatS and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2de7fca11d2cc0163a2faf969f703ac1
https://doi.org/10.1111/j.1365-2958.2011.07949.x

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