Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Kelly Bugatti"'
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Akademický článek
New 4-Aminoproline-Based Small Molecule Cyclopeptidomimetics as Potential Modulators of α4β1 Integrin
Autor: Andrea Sartori, Kelly Bugatti, Elisabetta Portioli, Monica Baiula, Irene Casamassima, Agostino Bruno, Francesca Bianchini, Claudio Curti, Franca Zanardi, Lucia Battistini
Publikováno v: Molecules, Vol 26, Iss 19, p 6066 (2021)
Integrin α4β1 belongs to the leukocyte integrin family and represents a therapeutic target of relevant interest given its primary role in mediating inflammation, autoimmune pathologies and cancer-related diseases. The focus of the present work is t
Externí odkaz: https://doaj.org/article/166aa7c11f0a4b829f71def7b9ba5c9c
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3
Nintedanib-αVβ6 Integrin Ligand Conjugates Reduce TGFβ-Induced EMT in Human Non-Small Cell Lung Cancer
Autor: Bianchini, Elena Andreucci, Kelly Bugatti, Silvia Peppicelli, Jessica Ruzzolini, Matteo Lulli, Lido Calorini, Lucia Battistini, Franca Zanardi, Andrea Sartori, Francesca
Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 2; Pages: 1475
Growth factors and cytokines released in the lung cancer microenvironment promote an epithelial-to-mesenchymal transition (EMT) that sustains the progression of neoplastic diseases. TGFβ is one of the most powerful inducers of this transition, as it
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::47c143c3284fce84724b9d41332ba470
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5
αVβ6Integrin: An Intriguing Target for COVID‐19 and Related Diseases
Autor: Kelly Bugatti
Publikováno v: ChemBioChem. 22:2516-2520
The outbreak of SARS-CoV-2 has been an extraordinary event that constituted a global health emergency. As the novel coronavirus is continuing to spread over the world, the need for therapeutic agents to control this pandemic is increasing. αV β6 In
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf44618f2082793c783134daefc70309
https://doi.org/10.1002/cbic.202100209
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7
Novel Polymyxin-Inspired Peptidomimetics Targeting the SARS-CoV-2 Spike:hACE2 Interface
Autor: Kelly Bugatti, Andrea Sartori, Lucia Battistini, Crescenzo Coppa, Emiel Vanhulle, Sam Noppen, Becky Provinciael, Lieve Naesens, Annelies Stevaert, Alessandro Contini, Kurt Vermeire, Franca Zanardi
Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 10; Pages: 8765
Though the bulk of the COVID-19 pandemic is behind, the search for effective and safe anti-SARS-CoV-2 drugs continues to be relevant. A highly pursued approach for antiviral drug development involves targeting the viral spike (S) protein of SARS-CoV-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a834bff5517ff4180111b604623dded
https://doi.org/10.3390/ijms24108765
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8
Shifting Towards αVβ6 Integrin Ligands Using Novel Aminoproline-Based Cyclic Peptidomimetics
Autor: Kelly Bugatti, Daniela Arosio, Lucia Battistini, Franca Zanardi, Agostino Bruno, Claudio Curti, Lisa Augustijn, Andrea Sartori
Publikováno v: Bugatti, K, Bruno, A, Arosio, D, Sartori, A, Curti, C, Augustijn, L, Zanardi, F & Battistini, L 2020, ' Shifting Towards α V β 6 Integrin Ligands Using Novel Aminoproline-Based Cyclic Peptidomimetics ', Chemistry-A European Journal, vol. 26, no. 59, pp. 13468-13475 . https://doi.org/10.1002/chem.202002554
Chemistry-A European Journal, 26(59), 13468-13475. Wiley-VCH Verlag
Chemistry (Weinh., Print) 26 (2020): 13468–13475. doi:10.1002/chem.202002554
info:cnr-pdr/source/autori:Bugatti, Kelly; Bruno, Agostino; Arosio, Daniela; Sartori, Andrea; Curti, Claudio; Augustijn, Lisa; Zanardi, Franca; Battistini, Lucia/titolo:Shifting Towards alpha(V)beta(6)Integrin Ligands Using Novel Aminoproline-Based Cyclic Peptidomimetics/doi:10.1002%2Fchem.202002554/rivista:Chemistry (Weinh., Print)/anno:2020/pagina_da:13468/pagina_a:13475/intervallo_pagine:13468–13475/volume:26
In recognition of the key role played by integrins in several life-threatening dysfunctions, the search for novel small-molecule probes that selectively recognize these surface receptors is still open and widely pursued. Inspired by previously establ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e10226cb46b8f97fa52ab9970e797efd
https://doi.org/10.1002/chem.202002554
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10
Nintedanib-αVβ6 Integrin Ligand Conjugates Reduce TGFβ-Induced EMT in Human Non-Small Cell Lung Cancer
Autor: Elena Andreucci, Kelly Bugatti, Silvia Peppicelli, Jessica Ruzzolini, Matteo Lulli, Lido Calorini, Lucia Battistini, Franca Zanardi, Andrea Sartori, Francesca Bianchini
Publikováno v: International Journal of Molecular Sciences. 24:1475
Growth factors and cytokines released in the lung cancer microenvironment promote an epithelial-to-mesenchymal transition (EMT) that sustains the progression of neoplastic diseases. TGFβ is one of the most powerful inducers of this transition, as it
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7dd0cf49e131d267b8723d68e885dd1
https://doi.org/10.3390/ijms24021475
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