Výsledky vyhledávání - "Kelly Beagan"

Akademický článek

Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair.

Autor: Kelly Beagan, Robin L Armstrong, Alice Witsell, Upasana Roy, Nikolai Renedo, Amy E Baker, Orlando D Schärer, Mitch McVey

Publikováno v: PLoS Genetics, Vol 13, Iss 5, p e1006813 (2017)

Double strand breaks (DSBs) and interstrand crosslinks (ICLs) are toxic DNA lesions that can be repaired through multiple pathways, some of which involve shared proteins. One of these proteins, DNA Polymerase θ (Pol θ), coordinates a mutagenic DSB

Externí odkaz: https://doaj.org/article/424f94cfac564df49822bba40c3fbed3

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Multiple mechanisms contribute to double-strand break repair at rereplication forks in Drosophila follicle cells

Autor: Kelly Beagan, Mitch McVey, Terry L. Orr-Weaver, Jessica L. Alexander

Rereplication generates double-strand breaks (DSBs) at sites of fork collisions and causes genomic damage, including repeat instability and chromosomal aberrations. However, the primary mechanism used to repair rereplication DSBs varies across differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c182030b5b5b19251f676ddbe6d12e65
https://europepmc.org/articles/PMC5137741/

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Linking DNA polymerase theta structure and function in health and disease

Autor: Mitch McVey, Kelly Beagan

Publikováno v: Cellular and molecular life sciences : CMLS. 73(3)

DNA polymerase theta (Pol θ) is an error-prone A-family polymerase that is highly conserved among multicellular eukaryotes and plays multiple roles in DNA repair and the regulation of genome integrity. Studies conducted in several model organisms ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902e2d9f2a5acf8ad8e187e59ac3ed31
https://pubmed.ncbi.nlm.nih.gov/26514729

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Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair

Autor: Alice Witsell, Amy Baker, Robin L. Armstrong, Orlando D. Schärer, Nikolai Renedo, Kelly Beagan, Upasana Roy, Mitch McVey

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 13, Iss 5, p e1006813 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f2609ce2308a4b84876695aecdc55f
https://doi.org/10.1371/journal.pgen.1006813

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