Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Kelly A. Zalocusky"'
Autor:
Stella A. Belonwu, Yaqiao Li, Daniel G. Bunis, Arjun Arkal Rao, Caroline Warly Solsberg, Tomiko Oskotsky, Alice L. Taubes, Brian Grone, Kelly A. Zalocusky, Gabriela K. Fragiadakis, Yadong Huang, Marina Sirota
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Alzheimer’s Disease (AD) is a complex neurodegenerative disease that gravely affects patients and imposes an immense burden on caregivers. Apolipoprotein E4 (APOE4) has been identified as the most common genetic risk factor for AD, yet the molecula
Externí odkaz:
https://doaj.org/article/8509af238faa46e3a867616383bbc66c
Autor:
Manish D. Paranjpe, Stella Belonwu, Jason K. Wang, Tomiko Oskotsky, Aarzu Gupta, Alice Taubes, Kelly A. Zalocusky, Ishan Paranjpe, Benjamin S. Glicksberg, Yadong Huang, Marina Sirota
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in the United States. In spite of evidence of females having a greater lifetime risk of developing Alzheimer’s Disease (AD) and
Externí odkaz:
https://doaj.org/article/f1b7beddceb6441c8e1f093b0d584ed2
Autor:
Ramsey Najm, Kelly A. Zalocusky, Misha Zilberter, Seo Yeon Yoon, Yanxia Hao, Nicole Koutsodendris, Maxine Nelson, Antara Rao, Alice Taubes, Emily A. Jones, Yadong Huang
Publikováno v:
Cell Reports, Vol 32, Iss 4, Pp 107962- (2020)
Summary: Despite its clear impact on Alzheimer’s disease (AD) risk, apolipoprotein (apo) E4’s contributions to AD etiology remain poorly understood. Progress in answering this and other questions in AD research has been limited by an inability to
Externí odkaz:
https://doaj.org/article/f1316fb3a2d5436abc74d71efac9cd01
Autor:
Kelly A. Zalocusky, Matthew J. Kan, Zicheng Hu, Patrick Dunn, Elizabeth Thomson, Jeffrey Wiser, Sanchita Bhattacharya, Atul J. Butte
Publikováno v:
Cell Reports, Vol 25, Iss 2, Pp 513-522.e3 (2018)
Summary: There is increasing appreciation that the immune system plays critical roles not only in the traditional domains of infection and inflammation but also in many areas of biology, including tumorigenesis, metabolism, and even neurobiology. How
Externí odkaz:
https://doaj.org/article/0414c90cfb3e4aaca39c6ac37aab65ca
Autor:
Yadong Huang, Alice Taubes, Marina Sirota, Tomiko Oskotsky, Misha Zilberter, Seo Yeon Yoon, Maureen E. Balestra, Jessica K De Freitas, Krishna Choudhary, Mesude Bicak, Benjamin S. Glicksberg, Brian P. Grone, Yanxia Hao, William Chang, Bin Chen, Ishan Paranjpe, Alice An, Celine Wang, Phil Nova, Emily Jones, Nuo Chen, Kelly A. Zalocusky, Nicole Koutsodendris, Fayzan Chaudhry, Silvia Pineda, Idit Kosti
Publikováno v:
Nature Aging. 1:932-947
The evident genetic, pathological and clinical heterogeneity of Alzheimer’s disease (AD) poses challenges for traditional drug development. We conducted a computational drug-repurposing screen for drugs to treat apolipoprotein E4 (APOE4)-related AD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::344ed394816c2d740eafbb790b588598
https://doi.org/10.1038/s43587-021-00122-7
https://doi.org/10.1038/s43587-021-00122-7
Autor:
Alice, Taubes, Phil, Nova, Kelly A, Zalocusky, Idit, Kosti, Mesude, Bicak, Misha Y, Zilberter, Yanxia, Hao, Seo Yeon, Yoon, Tomiko, Oskotsky, Silvia, Pineda, Bin, Chen, Emily A Aery, Jones, Krishna, Choudhary, Brian, Grone, Maureen E, Balestra, Fayzan, Chaudhry, Ishan, Paranjpe, Jessica, De Freitas, Nicole, Koutsodendris, Nuo, Chen, Celine, Wang, William, Chang, Alice, An, Benjamin S, Glicksberg, Marina, Sirota, Yadong, Huang
Publikováno v:
Nat Aging
The evident genetic, pathological, and clinical heterogeneity of Alzheimer’s disease (AD) poses challenges for traditional drug development. We conducted a computational drug repurposing screen for drugs to treat apolipoprotein (apo) E4-related AD.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::280579c1090f3d62b13565055133fa5b
https://pubmed.ncbi.nlm.nih.gov/36172600
https://pubmed.ncbi.nlm.nih.gov/36172600
Apolipoprotein E4 (APOE4) genotype and aging are critical risk factors for Alzheimer’s disease (AD). Aged APOE4 knock-in (APOE4-KI) mice have phenotypes reflecting features of AD. We conducted a large-scale single nucleus RNA-sequencing study to id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e10607644e0ca90bd0b18bd6c5a3753d
https://doi.org/10.1101/2022.06.16.496371
https://doi.org/10.1101/2022.06.16.496371
Autor:
Maxine Nelson, Yadong Huang, Seo Yeon Yoon, Dah-Eun J Amornkul, Kelly A. Zalocusky, Alice An, Antara Rao, Nicole Koutsodendris, Olga Cisne-Thomson, Jason Bant, David A. Bennett, Qin Xu, Yanxia Hao, Ramsey Najm, Alice Taubes
Publikováno v:
Nature neuroscience, vol 24, iss 6
Selective neurodegeneration is a critical causal factor in Alzheimer's disease (AD); however, the mechanisms that lead some neurons to perish, whereas others remain resilient, are unknown. We sought potential drivers of this selective vulnerability u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a02ccbc05aec0ca64aa09e92e099b2
https://doi.org/10.1038/s41593-021-00851-3
https://doi.org/10.1038/s41593-021-00851-3
Autor:
Stella A, Belonwu, Yaqiao, Li, Daniel G, Bunis, Arjun Arkal, Rao, Caroline Warly, Solsberg, Tomiko, Oskotsky, Alice L, Taubes, Brian, Grone, Kelly A, Zalocusky, Gabriela K, Fragiadakis, Yadong, Huang, Marina, Sirota
Publikováno v:
Frontiers in aging neuroscience. 14
Alzheimer's Disease (AD) is a complex neurodegenerative disease that gravely affects patients and imposes an immense burden on caregivers. Apolipoprotein E4 (APOE4) has been identified as the most common genetic risk factor for AD, yet the molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5fa4b1a2b040ed7dd32f8fa747698a77
https://pubmed.ncbi.nlm.nih.gov/35572130
https://pubmed.ncbi.nlm.nih.gov/35572130
Autor:
Caroline Warly Solsberg, Tomiko Oskotsky, Stella Belonwu, Marina Sirota, Daniel G. Bunis, Kelly A. Zalocusky, Arjun A. Rao, Brian P. Grone, Gabriela K. Fragiadakis, Yaqiao Li, Alice Taubes, Yadong Huang
Alzheimer’s Disease (AD) is a complex neurodegenerative disease that gravely affects patients and imposes an immense burden on caregivers. Apolipoprotein E4 (APOE4) has been identified as the most common genetic risk factor for AD, yet the molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57e0d71997a906ef9da48fb61905ee75
https://doi.org/10.21203/rs.3.rs-291648/v1
https://doi.org/10.21203/rs.3.rs-291648/v1