Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kelly A. Teske"'
Autor:
Kelly A. Teske, Andrew J. Wiemer, Sherry S Agabiti, Chia-Hung Christine Hsiao, Michael M. Poe, Caroline Liu, Victoria Li
Publikováno v:
J Med Chem
Small-molecule phosphoantigens such as (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate stimulate human Vγ9Vδ2 T cells after binding to the intracellular B30.2 domain of the immune receptor butyrophilin 3 isoform A1 (BTN3A1). To understand the ligand-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ffc2049e633ff6a4b095bccc46f3569
https://doi.org/10.1021/acs.jmedchem.9b00825
https://doi.org/10.1021/acs.jmedchem.9b00825
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:351-354
The vitamin D receptor is a nuclear hormone receptor that regulates cell proliferation, cell differentiation and calcium homeostasis. The receptor is endogenously activated by 1,25-dihydroxyvitamin D3, which induces transcription of VDR targets genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a65c1b75d3307e406efa8979ece53e7
https://doi.org/10.1016/j.bmcl.2017.12.041
https://doi.org/10.1016/j.bmcl.2017.12.041
Autor:
Adam Yasgar, David J. Maloney, Leggy A. Arnold, Ganesha Rai, Anton Simeonov, Preetpal S. Sidhu, Ajit Jadhav, Kelly A. Teske, Premchendar Nandhikonda, Belaynesh Feleke
Publikováno v:
ACS Combinatorial Science. 19:646-656
We describe the parallel synthesis of novel analogs of GW0742, a peroxisome proliferator-activated receptor δ (PPARδ) agonist. For that purpose, modified reaction conditions were applied, such as a solid-phase palladium-catalyzed Suzuki coupling. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01991c9b8bcebcc7d2369831617be4d
https://doi.org/10.1021/acscombsci.7b00066
https://doi.org/10.1021/acscombsci.7b00066
Autor:
Leggy A. Arnold, Xiaohua Peng, Varsha Gandhi, Kelly A. Teske, Heli Fan, Huabing Sun, Kumudha Balakrishnan, Yibin Wang, Quibria A. Guthrie, Zechao Lin, Sheng Cao, Wen-Bing Chen, Yukai Fan
Publikováno v:
European Journal of Medicinal Chemistry. 133:197-207
Quinone methide (QM) formation induced by endogenously generated H2O2 is attractive for biological and biomedical applications. To overcome current limitations due to low biological activity of H2O2-activated QM precursors, we are introducing herein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c3a1b5c29fa08dd0ef1d2abcd8c53a
https://doi.org/10.1016/j.ejmech.2017.03.041
https://doi.org/10.1016/j.ejmech.2017.03.041
Autor:
Angela M. Zaino, Lianne Q. Chau, Robert J. Wechsler-Reya, M. Kyle Hadden, Kelly A. Teske, Jennifer R Pace, Radha Charan Dash
Publikováno v:
J Med Chem
The FDA-approved antifungal agent, itraconazole (ITZ), has been increasingly studied for its novel biological properties. In particular, ITZ inhibits the hedgehog (Hh) signaling pathway and has the potential to serve as an anti-cancer chemotherapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ecef5820bd681b23a7a0cfb9f6a4ab0
https://pubmed.ncbi.nlm.nih.gov/30896941
https://pubmed.ncbi.nlm.nih.gov/30896941
Autor:
Douglas C. Stafford, Guanguan Li, Michael J. Krambis, Enrique Jambrina, Ashwini R Verma, Jeffrey M. Schkeryantz, Timothy M. Jones, Jeffrey M. Witkin, Leggy A. Arnold, Jeffrey W Cramer, Michael M. Poe, Margot Ernst, Kashi Reddy Methuku, Rok Cerne, Kelly A. Teske, James M. Cook, Sabah Rehman
Publikováno v:
Journal of Medicinal Chemistry. 59:10800-10806
1,4-Benzodiazepines are used in the treatment of anxiety disorders but have limited long-term use due to adverse effects. HZ-166 (2) has been shown to have anxiolytic-like effects with reduced sedative/ataxic liabilities. A 1,3-oxazole KRM-II-81 (9)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68c08c38815c1e1c7cf391ceba0f9b1c
https://doi.org/10.1021/acs.jmedchem.6b01332
https://doi.org/10.1021/acs.jmedchem.6b01332
Autor:
Jonathan W. Bogart, Daniel D. Bikle, Joshua Preston, Leggy A. Arnold, James M. Cook, Kelly A. Teske, Nicholas R. Silvaggi, Luis M. Sanchez, Olivia B. Yu
Publikováno v:
European Journal of Medicinal Chemistry. 109:238-246
A systematic study with phase 1 and phase 2 metabolites of cholesterol and vitamin D was conducted to determine whether their biological activity is mediated by the vitamin D receptor (VDR). The investigation necessitated the development of novel syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85e63d0f0d0c2afa55406d72bf2911f
https://doi.org/10.1016/j.ejmech.2016.01.002
https://doi.org/10.1016/j.ejmech.2016.01.002
Publikováno v:
European Journal of Medicinal Chemistry. 188:112008
microRNAs are small, noncoding RNA that negatively regulate gene expression. Since their discovery in 1993, approximately 2500 human mature microRNAs have been discovered and details of their biogenesis, mechanism of action, and function has been stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc81c1314aa306df384c848ec227d75
https://doi.org/10.1016/j.ejmech.2019.112008
https://doi.org/10.1016/j.ejmech.2019.112008
Publikováno v:
Bioorg Med Chem Lett
Dysregulation of the hedgehog (Hh) signaling pathway is associated with cancer occurrence and development in various malignancies. Previous structure-activity relationships (SAR) studies have provided potent Itraconazole (ITZ) analogues as Hh pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59686c24a22e3659c83d9f0c90342c22
https://doi.org/10.1016/j.bmcl.2019.126794
https://doi.org/10.1016/j.bmcl.2019.126794
Autor:
Robert J. Wechsler-Reya, Radha Charan Dash, M. Kyle Hadden, Shana R. Morel, Kelly A. Teske, Lianne Q. Chau
Inhibition of the hedgehog (Hh) signaling pathway has been validated as a therapeutic strategy to treat basal cell carcinoma and holds potential for several other forms of human cancer. Itraconazole and posaconazole are clinically useful triazole ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c451bc3f50a49966bf26389d93932b
https://europepmc.org/articles/PMC6358021/
https://europepmc.org/articles/PMC6358021/
