Data from On the Road to Precision Cancer Medicine: Analysis of Genomic Biomarker Actionability in 439 Patients

Autor: Razelle Kurzrock, Barbara A. Parker, Kelly A. Shimabukuro, Richard B. Schwab, Paul T. Fanta, David E. Piccioni, Gregory A. Daniels, Maria Schwaederle

Despite the increased use of molecular diagnostics, the extent to which patients who have these tests harbor potentially actionable aberrations is unclear. We retrospectively reviewed 439 patients with diverse cancers, for whom next-generation sequen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::058e4b1109886d1a1ecbcc1c7fec407b
https://doi.org/10.1158/1535-7163.c.6536761.v1

Genomics of gallbladder cancer: the case for biomarker-driven clinical trial design

Autor: Paul T. Fanta, Razelle Kurzrock, Kelly A. Shimabukuro, Jason K. Sicklick

Publikováno v: Cancer metastasis reviews, vol 35, iss 2

Background and aimsGallbladder carcinoma is a rare, aggressive malignancy of the biliary tract associated with a poor prognosis. Despite the deployment of targeted therapies that have demonstrated marked survival benefits in many tumor types, traditi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23263c7d89a3ba93bda536d5796cdec1
https://escholarship.org/uc/item/8pf0v0fx

Cyclin-dependent kinase pathway aberrations in diverse malignancies: Clinical and molecular characteristics

Autor: Shumei Kato, Razelle Kurzrock, Barbara A. Parker, Lyudmila Bazhenova, Maria Schwaederle, Kelly A. Shimabukuro, Gregory A. Daniels, Santosh Kesari, Paul T. Fanta, David Piccioni

Publikováno v: Kato, S; Schwaederle, M; Daniels, GA; Piccioni, D; Kesari, S; Bazhenova, L; et al.(2015). Cyclin-dependent kinase pathway aberrations in diverse malignancies: Clinical and molecular characteristics. Cell Cycle, 14(8), 1252-1259. doi: 10.1080/15384101.2015.1014149. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/166790fw
Cell cycle (Georgetown, Tex.), vol 14, iss 8
Cell Cycle

© Taylor " Francis Group, LLC. Aberrations in the cyclin-dependent kinase (CDK) pathways that regulate the cell cycle restriction point contribute to genomic instability and tumor proliferation, and can be targeted by recently developed CDK inhibito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ffbf1e3e450116c1c38d4ce175aead
http://www.escholarship.org/uc/item/166790fw

Next generation sequencing demonstrates association between tumor suppressor gene aberrations and poor outcome in patients with cancer

Autor: Santosh Kesari, Maria Schwaederle, Razelle Kurzrock, Barbara A. Parker, Richard Schwab, David Piccioni, Paul T. Fanta, Kelly A. Shimabukuro, Gregory A. Daniels

Publikováno v: Cell cycle (Georgetown, Tex.), vol 14, iss 11
Schwaederle, M; Daniels, GA; Piccioni, DE; Kesari, S; Fanta, PT; Schwab, RB; et al.(2015). Next generation sequencing demonstrates association between tumor suppressor gene aberrations and poor outcome in patients with cancer. Cell Cycle, 14(11), 1730-1737. doi: 10.1080/15384101.2015.1033596. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/5sd09610
Cell Cycle

Next generation sequencing is transforming patient care by allowing physicians to customize and match treatment to their patients’ tumor alterations. Our goal was to study the association between key molecular alterations and outcome parameters. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e5a877f793255fda4daf1ddda04078b
https://escholarship.org/uc/item/5sd09610

Reduced levels of connexin43 in cervical dysplasia: inducible expression in a cervical carcinoma cell line decreases neoplastic potential with implications for tumor progression

Autor: A. David Hieber, Kelly A. Shimabukuro, Laurie H. Fukushima, Wael Sakr, Timothy J. King, John S. Bertram

Publikováno v: Carcinogenesis. 21:1097-1109

Loss of gap junctional intercellular communication (GJIC) has been linked to aberrant proliferation and an enhanced neoplastic phenotype. Many human tumors, including the cervical carcinoma line HeLa, have been reported to be deficient in expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::165bae6aea68d5e2f3a861d31be07a08
https://doi.org/10.1093/carcin/21.6.1097