Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kelly A. Regal"'
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 11:481-489
To evaluate the pharmacokinetic (PK) characteristics of a modified fentanyl iontophoretic transdermal system (ITS).This was a prospective, open-label, single-center, randomized, 3-period, 5-treatment, 6-sequence study. Each subject was randomly assig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac5e9150a97634ff018833ce342ee58
https://doi.org/10.1517/17425255.2015.1020296
https://doi.org/10.1517/17425255.2015.1020296
Publikováno v:
Chemical Research in Toxicology. 19:279-287
The oral contraceptive 17-α-ethynylestradiol (17EE) is a mechanism-based inactivator of cytochrome P450s (P450s) 2B1 and 2B6. Inactivation of P450s 2B1 and 2B6 in the reconstituted system by [3H]17EE resulted in labeling of the P450 apoprotein. Mass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2694b4a9cf55731481b55911e77331b
https://doi.org/10.1021/tx050256o
https://doi.org/10.1021/tx050256o
Publikováno v:
Chemical Research in Toxicology. 14:1014-1024
The pneumotoxin 3-methylindole is metabolized to the reactive intermediate 3-methyleneindolenine which has been shown to form adducts with glutathione and proteins. Reported here is the synthesis, detection, and characterization of nucleoside adducts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91f495994778192475a300f801f0978
https://doi.org/10.1021/tx0100237
https://doi.org/10.1021/tx0100237
Autor:
Sidney D. Nelson, Kelly A. Regal
Publikováno v:
Archives of Biochemistry and Biophysics. 384:47-58
Longitudinal (T1) relaxation studies were performed in order to examine the interaction of caffeine with the heme of human P450 1A2. Addition of caffeine to this P450 resulted in a small, incomplete conversion of the heme from high spin to low spin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c2fec4de9dda037e2ff140bb7bfd55
https://doi.org/10.1006/abbi.2000.2073
https://doi.org/10.1006/abbi.2000.2073
Autor:
Mohamoud M. Abdi, Nabil Hussain Al-Humadi, Mayssa Attar, Theodore J. Baird, Jeff Behrens, Nathan Boersen, Jacqueline A. Brassard, Melissa J. Beck, Jennifer G. Brown, Edward W. Carney, Ting-Tung A. Chang, Mingli Chen, Dorothy B. Colagiovanni, John B. Colerangle, Roger Collins, Rebecca Dabora, Jill A. Dalton, Kevin H. Denny, Rodney R. Dietert, Forbes P. Donald, J. Neil Duncan, John T. Farmer, Ali S. Faqi, Stephen Frantz, Les Freshwater, Tobias C. Fuchs, David V. Gauvin, Martin David Green, Lining Guo, Scott P. Henry, Philip G. Hewitt, Alan Hoberman, Ho-Wah Hui, Julia Y. Hui, Colleen Johnson, John W. Kille, Andrea S. Kim, Tae-Won Kim, Neil Kirby, Douglas Kornbrust, Douglas B. Learn, Thomas Lee, Elise Lewis, Steven Matsumoto, David L. McCormick, Kathleen B. Meyer-Tamaki, Odete R. Mendes, Michael V. Milburn, Igor Mikaelian, LaRonda L. Morford, John Nicolette, Paul Nugent, Hyesun H. Oh, Lekan Oyejide, Meg Ramos, Kelly A. Regal, David Rehagen, John Cody Resendez, John A. Ryals, Christopher P. Sambuco, Michael Schrag, David G. Serota, Raja Settivari, Richard Slauter, Christopher W. Stewart, Donald Stump, Sekhar Surapaneni, Michael Templin, Bjorn A. Thorsrud, Germaine L. Truisi, Chang Vangyi, Tom Vidmar, Jim Vrbanac, Qingli Wang, Zheng J. Wang, Lawrence O. Whitely, James S. Yan, Malcolm J. York, Husam S. Younis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2aa595349a72c0097cbac46cf9de6668
https://doi.org/10.1016/b978-0-12-387815-1.10037-1
https://doi.org/10.1016/b978-0-12-387815-1.10037-1
Publikováno v:
Drug Metabolism and Disposition.
Caffeine (1,3,7-trimethylxanthine) has previously been shown to undergo metabolic switching in vivo when the N-1 or the N-7 methyl groups were trideuteromethylated [Horning et al. (1976) Proceedings of the Second International Conference on Stable Is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7777b9671ad3a4d60a04129bbebabbd7
https://doi.org/10.1124/dmd.105.006031
https://doi.org/10.1124/dmd.105.006031
Publikováno v:
Chemical research in toxicology. 13(4)
7-Ethynylcoumarin was synthesized as a potential mechanism-based inhibitor, and it was found to be an effective inactivator of 7-ethoxy-4-(trifluoromethyl)coumarin (7EFC) O-deethylation catalyzed by purified, reconstituted P450 2B1. In contrast, 7-et
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b1ca8b373458f09c09169b29e6b36d
https://pubmed.ncbi.nlm.nih.gov/10775326
https://pubmed.ncbi.nlm.nih.gov/10775326
Autor:
Kelly A. Regal, Raimund M. Peter, William N. Howald, Kent L. Kunze, Carlos A. Gartner, Sidney D. Nelson
Publikováno v:
Journal of chromatography. B, Biomedical sciences and applications. 708(1-2)
A method for the quantification of subnanomolar levels of in vitro metabolites of caffeine by an isotope dilution gas chromatographic–mass spectrometric (GC–MS) assay has been developed and applied. Trideuteromethylated analogs of each primary me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87fe6c72517d9f199964d0024de5a1c
https://pubmed.ncbi.nlm.nih.gov/9653949
https://pubmed.ncbi.nlm.nih.gov/9653949