Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Kelly A. Newell"'
Autor:
Jessica L. Andrews, Andrew Zalesky, Shalima Nair, Ryan P. Sullivan, Melissa J. Green, Christos Pantelis, Kelly A. Newell, Francesca Fernandez
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15624 (2023)
Leucine-rich repeat and immunoglobulin domain-containing protein (Lingo-1) plays a vital role in a large number of neuronal processes underlying learning and memory, which are known to be disrupted in schizophrenia. However, Lingo-1 has never been ex
Externí odkaz:
https://doaj.org/article/b4d47297b9104fa79d017f7401f046d9
Autor:
Gabrielle R. Phillips, Sarah E. Hancock, Andrew M. Jenner, Catriona McLean, Kelly A. Newell, Todd W. Mitchell
Publikováno v:
Nutrients, Vol 14, Iss 10, p 2086 (2022)
Huntington’s disease (HD) is a genetic, neurodegenerative illness that onsets in late adulthood as a series of progressive and terminal cognitive, motor, and psychiatric deficits. The disease is caused by a polyQ mutation in the Huntingtin gene (HT
Externí odkaz:
https://doaj.org/article/6d59c3dc86964a5284aa46806574acce
Autor:
Yi Liu, Yuyun Zhang, Xian Zheng, Tongyong Fang, Xia Yang, Xuan Luo, Anlei Guo, Kelly A. Newell, Xu-Feng Huang, Yinghua Yu
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-15 (2018)
Abstract Background Neuroinflammation plays an important role in the onset and progression of neurodegenerative diseases such as Alzheimer’s disease. Lipopolysaccharide (LPS, endotoxin) levels are higher in the brains of Alzheimer’s disease patie
Externí odkaz:
https://doaj.org/article/8ac32ec564254fd987ca5b803d523c60
Autor:
Yi Liu, Jie Huang, Xian Zheng, Xia Yang, Yan Ding, Tongyong Fang, Yuyun Zhang, Shuaishuai Wang, Xiaofei Zhang, Xuan Luo, Anlei Guo, Kelly A. Newell, Yinghua Yu, Xu-Feng Huang
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Methylglyoxal (MG) accumulation has been observed in human cerebrospinal fluid and body tissues under hyperglycaemic conditions. Recent research has demonstrated that MG-induces neuronal cell apoptosis, which promotes the development of diab
Externí odkaz:
https://doaj.org/article/9cfd609f8aa54a7884e456f962e96767
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 2, Pp 171-173 (2014)
Science is often romanticised as a flawless system of knowledge building, where scientists work together to systematically find answers. In reality, this is not always the case. Dissemination of results are straightforward when the findings are posit
Externí odkaz:
https://doaj.org/article/df5d6474379d481ab067dc342a84ffac
Autor:
Samara J. Brown, Amelia M. Brown, Tertia D. Purves-Tyson, Xu-Feng Huang, Cynthia Shannon Weickert, Kelly A. Newell
Publikováno v:
Journal of Psychiatric Research. 160:204-209
Autor:
Noor S. Jarbou, Kelly A. Newell
Publikováno v:
Archives of Women's Mental Health. 25:539-559
Autor:
Simon H. J. Brown, Fabian Kreilaus, Sarah E. Hancock, Andrew M. Jenner, Todd W. Mitchell, Kelly A. Newell, Gabrielle R. Phillips
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Huntington’s disease (HD) is an autosomal dominant neurodegenerative illness caused by a mutation in the huntingtin gene (HTT) and subsequent protein (mhtt), to which the brain shows a region-specific vulnerability. Disturbances in neural cholester
Autor:
Gabrielle R. Phillips, Jennifer T. Saville, Sarah E. Hancock, Simon H. J. Brown, Andrew M. Jenner, Catriona McLean, Maria Fuller, Kelly A. Newell, Todd W. Mitchell
Publikováno v:
Brain Communications. 4
Huntington’s disease is a devastating neurodegenerative disorder that onsets in late adulthood as progressive and terminal cognitive, psychiatric and motor deficits. The disease is genetic, triggered by a CAG repeat (polyQ) expansion mutation in th
Autor:
Samara J. Brown, Amelia M. Brown, Tertia D. Purves-Tyson, Xu-Feng Huang, Cynthia Shannon Weickert, Kelly A. Newell
Publikováno v:
Journal of psychiatric research. 147
Evidence, largely obtained from peripheral studies, suggests that alterations in the kynurenine pathway contribute to the aetiology of depression and disorders involving psychosis. Stimulation of the kynurenine pathway leads to the formation of neuro