Výsledky vyhledávání - "Kelly A. Heys"

Vibrational biospectroscopy characterizes biochemical differences between cell types used for toxicological investigations and identifies alterations induced by environmental contaminants

Autor: M. Glória Pereira, Richard F. Shore, Kelly A. Heys, Francis Martin

Publikováno v: Environmental Toxicology and Chemistry. 36:3127-3137

The use of cell-based assays is essential in reducing the number of vertebrates used in the investigation of chemical toxicities and in regulatory toxicology assessment. An important factor in obtaining meaningful results which can be accurately extr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85e6bb5fcaa14ad3caebc1e4778de3f1
https://doi.org/10.1002/etc.3890

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Levels of Organochlorine Pesticides Are Associated with Amyloid Aggregation in Apex Avian Brains

Autor: M. Glória Pereira, Richard F. Shore, Kelly A. Heys, Francis Martin

Publikováno v: Environmental Science & Technology. 51:8672-8681

Organochlorine (OC) pesticides pose a significant environmental risk to wildlife and humans and have been associated with Alzheimer’s disease (AD). This study aims to spectroscopically analyse brains from free-flying birds and link the results to O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d1427237149988b718358c45d2d52d
https://doi.org/10.1021/acs.est.7b00840

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Risk assessment of environmental mixture effects

Autor: Kevin C. Jones, M. Glória Pereira, Kelly A. Heys, Richard F. Shore, Francis Martin

Publikováno v: RSC Advances

In the environment, organisms are exposed to a diverse array of chemicals in complex mixtures. The majority of approaches that aim to assess the risk of environmental chemical mixtures, including those used by regulatory bodies, use toxicity data gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60362be2b56142eba8c8289314250bc3
https://doi.org/10.1039/c6ra05406d

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An imaging dataset of cervical cells using scanning near-field optical microscopy coupled to an infrared free electron laser

Autor: Marco Luce, Kássio M. G. Lima, Maria Kyrgiou, Camilo L. M. Morais, James Ingham, Júlio Trevisan, Tim J. Craig, Pierre L. Martin-Hirsch, Georgios Theophilou, Antonio Cricenti, Francis Martin, Kelly A. Heys, Anita Mitra, Evangelos Paraskevaidis, Michele R.F. Siggel-King, Peter Weightman, Diane E. Halliwell, David Martin

Publikováno v: Scientific Data
Scientific data 4 (2017). doi:10.1038/sdata.2017.84
info:cnr-pdr/source/autori:Halliwell, Diane E.; Morais, Camilo L. M.; Lima, Kassio M. G.; Trevisan, Julio; Siggel-King, Michele R. F.; Craig, Tim; Ingham, James; Martin, David S.; Heys, Kelly; Kyrgiou, Maria; Mitra, Anita; Paraskevaidis, Evangelos; Theophilou, Georgios; Martin-Hirsch, Pierre L.; Cricenti, Antonio; Luce, Marco; Weightman, Peter; Martin, Francis L./titolo:An imaging dataset of cervical cells using scanning near-field optical microscopy coupled to an infrared free electron laser/doi:10.1038%2Fsdata.2017.84/rivista:Scientific data/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:4
SCIENTIFIC DATA
Halliwell, D, Morais, C, Lima, K, Trevisan, J, Siggel-King, M, Craig, T, Ingham, J, Martin, D, Heys, K, Kyrgiou, M, Mitra, A, Paraskevaidis, E, Theophilou, G, Martin-Hirsch, P, Cricenti, A, Luce, M, Weightman, P & Martin, F 2017, ' An imaging dataset of cervical cells using scanning near-field optical microscopy coupled to an infrared free electron laser ', Scientific Data, vol. 4 . https://doi.org/10.1038/sdata.2017.84

Using a scanning near-field optical microscope coupled to an infrared free electron laser (SNOM-IR-FEL) in low-resolution transmission mode, we collected chemical data from whole cervical cells obtained from 5 pre-menopausal, non-pregnant women of re

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Mid-infrared spectroscopic assessment of nanotoxicity in Gram-negative vs. Gram-positive bacteria

Autor: Kirk T. Semple, Matthew J. Riding, Rebecca J. Strong, Richard F. Shore, Francis Martin, Kevin C. Jones, Gloria Dos Santos Pereira, Kelly A. Heys

Publikováno v: The Analyst. 139:896-905

Nanoparticles appear to induce toxic effects through a variety of mechanisms including generation of reactive oxygen species (ROS), physical contact with the cell membrane and indirect catalysis due to remnants from manufacture. The development and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795b47aef6b68c4c9edb611be1e44481
https://doi.org/10.1039/c3an01649h

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Imaging cervical cytology with scanning near-field optical microscopy (SNOM) coupled with an IR-FEL

Autor: Diane E, Halliwell, Camilo L M, Morais, Kássio M G, Lima, Julio, Trevisan, Michele R F, Siggel-King, Tim, Craig, James, Ingham, David S, Martin, Kelly A, Heys, Maria, Kyrgiou, Anita, Mitra, Evangelos, Paraskevaidis, Georgios, Theophilou, Pierre L, Martin-Hirsch, Antonio, Cricenti, Marco, Luce, Peter, Weightman, Francis L, Martin

Publikováno v: Scientific Reports

Cervical cancer remains a major cause of morbidity and mortality among women, especially in the developing world. Increased synthesis of proteins, lipids and nucleic acids is a pre-condition for the rapid proliferation of cancer cells. We show that s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::281c417a205b96d125052e2c436a6fe0
https://pubmed.ncbi.nlm.nih.gov/27406404

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Spatial and temporal age-related spectral alterations in benign human breast tissue

Autor: Rebecca J. Strong, Helen F. Stringfellow, Francis Martin, Simon W. Fogarty, Júlio Trevisan, Georgios Theophilou, Kelly A. Heys, Imran I. Patel, Pierre L. Martin-Hirsch

Epidemiological evidence suggests that cancers attributable to exogenous carcinogenic agents may appear decades after initiating exposures. Environmental factors including lifestyle and/or diet have been implicated in the aetiology of breast cancer.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8625f614b06efb25fb6c2a437a035f
https://doi.org/10.1016/j.molstruc.2015.11.003

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Using Fourier transform IR spectroscopy to analyze biological materials

IR spectroscopy is an excellent method for biological analyses. It enables the nonperturbative, label-free extraction of biochemical information and images toward diagnosis and the assessment of cell functionality. Although not strictly microscopy in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055ff5d8e15ba2c62f89eda2d4b34e9c
https://doi.org/10.1038/nprot.2014.110

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