Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kelly A. Bachovchin"'
Autor:
Sean Ekins, Renata Barbosa de Oliveira, Carolina Horta Andrade, Lori Ferrins, Kelly A. Bachovchin, Melina Mottin, Conor R. Caffrey, Dietmar Steverding, Ludovica Monti, Rafaela Salgado Ferreira, Kimberley M. Zorn, Carlo Ballatore, Jair L. Siqueira-Neto, Daniel H. Foil, Anthony J. O’Donoghue, Alex M. Clark, Michael P. Pollastri
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
We review the disease, biology and biochemistry of kinetoplastids, as well as the new drugs and drug candidates that have entered the clinic in the last decade. We also describe examples of the pre-clinical exploration of small molecules against vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87869294de138eba8ccf601921072f10
https://doi.org/10.1002/0471266949.bmc235.pub2
https://doi.org/10.1002/0471266949.bmc235.pub2
Autor:
Julia Medeiros Souza, Everton M Silva, Jessey Erath, Diane Thomas, James H. McKerrow, Lori Ferrins, Baljinder Singh, Erica Penn, Robert F. Campbell, Jair L. Siqueira-Neto, Ana Rodriguez, Jean A. Bernatchez, Susan E. Leed, Norma Roncal, Hitesh B. Jalani, Jasmin Ackermann, Michael P. Pollastri, Dana M. Klug, Laura-Isobel McCall, Kelly A. Bachovchin, Claudia M. Calvet, Richard J. Sciotti, Seema Bag, Melissa J. Buskes
Publikováno v:
ACS Med Chem Lett
[Image: see text] Utilizing a target repurposing and parasite-hopping approach, we tested a previously reported library of compounds that were active against Trypanosoma brucei, plus 31 new compounds, against a variety of protozoan parasites includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd9aed31503ad64e9e28813b5711662c
https://doi.org/10.1021/acsmedchemlett.9b00453
https://doi.org/10.1021/acsmedchemlett.9b00453
Autor:
Lori Ferrins, Melissa J. Buskes, Conor R. Caffrey, Hitesh B. Jalani, Dana M. Klug, Kelly A. Bachovchin, Nelly El-Sakkary, Allison Leonard, Baljinder Singh, Robert F. Campbell, Michael P. Pollastri, Richard J. Sciotti, Seema Bag, Monica Clements
Publikováno v:
ACS Medicinal Chemistry Letters
We recently reported a series of compounds for a solubility-driven optimization campaign of antitrypanosomal compounds. Extending a parasite-hopping approach to the series, a subset of compounds from this library has been cross-screened for activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8ee50ddcb2576fc6178e843d54b7e1
http://europepmc.org/articles/PMC7073886
http://europepmc.org/articles/PMC7073886
Autor:
Kimberly G. Brady, Richard J. Sciotti, Mitchell F. Gallerstein, Jessey Erath, Jennifer L. Woodring, Kelly A. Bachovchin, Ana Rodriguez, Susan E. Leed, Kojo Mensa-Wilmot, Scott Tanghe, Michael P. Pollastri
Publikováno v:
European Journal of Medicinal Chemistry. 141:446-459
Human African trypanosomiasis (HAT) is a deadly disease in need of new chemotherapeutics that can cross into the central nervous system. We previously reported the discovery of 2 (NEU-617), a small molecule with activity against T. brucei bloodstream
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ac3197a1f70ef8d9d7ab13e0674a32
https://doi.org/10.1016/j.ejmech.2017.10.007
https://doi.org/10.1016/j.ejmech.2017.10.007
Autor:
Dana M. Klug, Richard J. Sciotti, Baljinder Singh, Seema Bag, Kojo Mensa-Wilmot, Jeremiah D. Momper, Hitesh B. Jalani, Ana Rodriguez, Melissa J. Buskes, Kelly A. Bachovchin, Katherine M. Schneider, Michael P. Pollastri, Scott Tanghe, Lori Ferrins, Amrita Sharma, Naimee Mehta
Publikováno v:
Journal of medicinal chemistry, vol 62, iss 2
Lapatinib, an approved epidermal growth factor receptor inhibitor, was explored as a starting point for the synthesis of new hits against Trypanosoma brucei, the causative agent of human African trypanosomiasis (HAT). Previous work culminated in 1 (N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9d04f11b4d25eb3432d3d37479f934
https://escholarship.org/uc/item/0qv0q4v1
https://escholarship.org/uc/item/0qv0q4v1
Autor:
William G. Devine, Richard J. Sciotti, Kelly A. Bachovchin, Sarah M. Thomas, Susan E. Leed, Jessey Erath, Kojo Mensa-Wilmot, Patricia J. Lee, Ana Rodriguez, Michael P. Pollastri
Publikováno v:
ACS Medicinal Chemistry Letters
Human African trypanosomiasis (HAT), Chagas disease, and leishmaniasis present a significant burden across the developing world. Existing therapeutics for these protozoal neglected tropical diseases suffer from severe side effects and toxicity. Previ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1100b20152251c30bfb6315eb2698fd0
https://pubmed.ncbi.nlm.nih.gov/28337329
https://pubmed.ncbi.nlm.nih.gov/28337329
Autor:
Kimberly G. Brady, Mitchell F. Gallerstein, Michael P. Pollastri, Richard J. Sciotti, Scott Tanghe, Susan E. Leed, Kojo Mensa-Wilmot, Ana Rodriguez, Jessey Erath, Kelly A. Bachovchin, Jennifer L. Woodring
Publikováno v:
European Journal of Medicinal Chemistry. 152:515
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11d135cae55a1ff72f0d0531ede47ee8
https://doi.org/10.1016/j.ejmech.2018.05.002
https://doi.org/10.1016/j.ejmech.2018.05.002
Autor:
Maria Rosa Mazzoni, A. Fazzini, Annette Gilchrist, K M Alley, J L Yarfi, D S Pyen, S J Ha, S E Sansom, J Ahn, T D Gauntner, J R Merritt, A Willett, Kelly A. Bachovchin
Publikováno v:
British Journal of Pharmacology.
Background and Purpose Investigators have suggested that the chemokine receptor CCR1 plays a role in multiple myeloma. Studies using antisense and neutralizing antibodies to CCR1 showed that down-regulation of the receptor altered disease progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bf2852ac826f60b512a9d7f838d9893
https://doi.org/10.1111/bph.12835
https://doi.org/10.1111/bph.12835