Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kelly A Mitok"'
Autor:
Christopher H Emfinger, Lauren E Clark, Brian Yandell, Kathryn L Schueler, Shane P Simonett, Donnie S Stapleton, Kelly A Mitok, Matthew J Merrins, Mark P Keller, Alan D Attie
Publikováno v:
eLife, Vol 12 (2023)
Insufficient insulin secretion to meet metabolic demand results in diabetes. The intracellular flux of Ca2+ into β-cells triggers insulin release. Since genetics strongly influences variation in islet secretory responses, we surveyed islet Ca2+ dyna
Externí odkaz:
https://doaj.org/article/de0ff10cf88640b2b8b46a53e15528a6
Autor:
Kelly A. Mitok, Kathryn L. Schueler, Sarah M. King, Joseph Orr, Kathleen A. Ryan, Mark P. Keller, Ronald M. Krauss, Braxton D. Mitchell, Alan R. Shuldiner, Alan D. Attie
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 12, Pp 100468- (2023)
Common noncoding variants at the human 1p13.3 locus associated with SORT1 expression are among those most strongly associated with low-density lipoprotein cholesterol (LDL-C) in human genome-wide association studies. However, validation studies in mi
Externí odkaz:
https://doaj.org/article/c1be21f245b04a43b1a714819dee4fd0
Novel regulators of islet function identified from genetic variation in mouse islet Ca2+oscillations
Autor:
Christopher H. Emfinger, Lauren E. Clark, Brian Yandell, Kathryn L. Schueler, Shane P. Simonett, Donnie S. Stapleton, Kelly A. Mitok, Matthew J. Merrins, Mark P. Keller, Alan D. Attie
Insufficient insulin secretion to meet metabolic demand results in diabetes. The intracellular flux of Ca2+into β-cells triggers insulin release. Since genetics strongly influences variation in islet secretory responses, we surveyed islet Ca2+dynami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1df50c6b59c07f51672ceb5e0a7726fb
https://doi.org/10.1101/2022.11.26.517741
https://doi.org/10.1101/2022.11.26.517741
Autor:
Kelly L. Hudkins, Mark J. Graham, Alan D. Attie, Shane P Simonett, Kelly A. Mitok, Kathryn M. Schueler, Richard G. Lee, Charles E. Alpers, Kunaal Mehrotra, Mark P. Keller
Publikováno v:
Lab Invest
The etiology of diabetic nephropathy in type 2 diabetes is multifactorial. Sustained hyperglycemia is a major contributor, but additional contributions come from the hypertension, obesity, and hyperlipidemia that are also commonly present in patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1175aa535e16c6e3abd2bbff3635dbd
https://doi.org/10.1038/s41374-021-00592-8
https://doi.org/10.1038/s41374-021-00592-8
Autor:
Christopher H. Emfinger, Eleonora de Klerk, Kathryn L. Schueler, Mary E. Rabaglia, Donnie S. Stapleton, Shane P. Simonett, Kelly A. Mitok, Ziyue Wang, Xinyue Liu, Joao A. Paulo, Qinq Yu, Rebecca L. Cardone, Hannah R. Foster, Sophie L. Lewandowski, José C. Perales, Christina M. Kendziorski, Steven P. Gygi, Richard G. Kibbey, Mark P. Keller, Matthias Hebrok, Matthew J. Merrins, Alan D. Attie
Publikováno v:
JCI insight. 7(10)
Insulin secretion from pancreatic β cells is essential for glucose homeostasis. An insufficient response to the demand for insulin results in diabetes. We previously showed that β cell-specific deletion of Zfp148 (β-Zfp148KO) improves glucose tole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17cd028299536c9975e06e2656e3f931
https://pubmed.ncbi.nlm.nih.gov/35603790
https://pubmed.ncbi.nlm.nih.gov/35603790
Autor:
Daniel M. Gatti, Rahul Das, Brian S. Yandell, Kelly A. Mitok, Ziyue Wang, Mark P. Keller, Donnie S. Stapleton, Matthew Vincent, Karl W. Broman, Kathryn L. Schueler, Shane P Simonett, Takanao Ishimura, Alan D. Attie, Mary E. Rabaglia, Gary A. Churchill, Christopher H. Emfinger, Tim Beck, Christina Kendziorski
Publikováno v:
J Clin Invest
Genetic susceptibility to type 2 diabetes is primarily due to β cell dysfunction. However, a genetic study to directly interrogate β cell function ex vivo has never been previously performed. We isolated 233,447 islets from 483 Diversity Outbred (D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92559fa4a4a53bb3d540f6e22c7b3817
https://doi.org/10.1172/jci129143
https://doi.org/10.1172/jci129143
Publikováno v:
Journal of Lipid Research. 63:100243
Sortilin is a post-Golgi trafficking receptor homologous to the yeast vacuolar protein sorting receptor 10 (VPS10). The VPS10 motif on sortilin is a 10-bladed β-propeller structure capable of binding more than 50 proteins, covering a wide range of b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9e9900470aaa8f8fa990328f704ee1
https://doi.org/10.1016/j.jlr.2022.100243
https://doi.org/10.1016/j.jlr.2022.100243
Publikováno v:
The Journal of Cell Biology
Zhang et al. conducted a siRNA screen of C2 domain proteins involved in regulated peptide secretion. One of the hits, a Munc13 family member BAIAP3, was characterized as endosome localized involved in post-exocytic dense-core vesicle protein recyclin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a233d42119ff3b98d425b10f2a8976
https://doi.org/10.1083/jcb.201702099
https://doi.org/10.1083/jcb.201702099
Autor:
Nicholas W. Kwiecien, Donald S. Stapleton, Kelly A. Mitok, Kathryn L. Schueler, Joshua J. Coon, Alexander S. Hebert, Robert T. Kennedy, Mary E. Rabaglia, Mark P. Keller, Alan D. Attie, Elyse C. Freiberger, Paige A. Malec, Aimee Teo Broman
The mouse is a critical model in diabetes research, but most research in mice has been limited to a small number of mouse strains and limited genetic variation. Using the eight founder strains and both sexes of the Collaborative Cross (C57BL/6J (B6),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476f53810824558bd6595d52039b1fc5
https://europepmc.org/articles/PMC5912463/
https://europepmc.org/articles/PMC5912463/
Autor:
Kathryn L. Schueler, Lindsay S. Wrighton, Alan D. Attie, Adam Johnson, Donald S. Stapleton, Anjon Audhya, Kevin W. Eliceiri, Allison J. Balloon, Nabil G. Seidah, Mark P. Keller, Melkam A. Kebede, Oliver C. Richards, Summer M. Raines, Mary E. Rabaglia, Candice Thorstenson, Trillian Gregg, Angie T. Oler, Kelly A. Mitok, Joshua L. Coon, Brendan J. Floyd, Christopher J. Rhodes
Publikováno v:
The Journal of clinical investigation. 124(10)
We previously positionally cloned Sorcs1 as a diabetes quantitative trait locus. Sorcs1 belongs to the Vacuolar protein sorting-10 (Vps10) gene family. In yeast, Vps10 transports enzymes from the trans-Golgi network (TGN) to the vacuole. Whole-body S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb06fb5ab4086d9171b762c68cfd28a0
https://pubmed.ncbi.nlm.nih.gov/25157818
https://pubmed.ncbi.nlm.nih.gov/25157818