Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Kelly A Fader"'
Autor:
Giovan N. Cholico, Karina Orlowska, Russell R. Fling, Warren J. Sink, Nicholas A. Zacharewski, Kelly A. Fader, Rance Nault, Tim Zacharewski
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant that induces the progression of steatosis to steatohepatitis with fibrosis in mice. Furthermore, TCDD reprograms hepatic metabolism by redirecting glycolyti
Externí odkaz:
https://doaj.org/article/b4286f4e342e494dbb3d2ec0f8e1f9fb
Autor:
Kelly A. Fader, Ingrid D. Pardo, Ramesh C. Kovi, Christopher J. Somps, Helen Hong Wang, Vishal S. Vaidya, Shashi K. Ramaiah, Madhu P. Sirivelu
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 264-277 (2022)
Adeno-associated virus (AAV)-induced dorsal root ganglia (DRG) toxicity has been observed in several nonclinical species, where lesions are characterized by neuronal degeneration/necrosis, nerve fiber degeneration, and mononuclear cell infiltration.
Externí odkaz:
https://doaj.org/article/86125310200649c0a9c68fcd0e3733f4
Autor:
Giovan N. Cholico, Russell R. Fling, Nicholas A. Zacharewski, Kelly A. Fader, Rance Nault, Timothy R. Zacharewski
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a persistent environmental contaminant, induces steatosis by increasing hepatic uptake of dietary and mobilized peripheral fats, inhibiting lipoprotein export, and repressing β-oxidation. In this
Externí odkaz:
https://doaj.org/article/c45e1cdb4ce34f019fc7bb449eff6b5a
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 147-159 (2021)
Background and Aims: Characterization of cell specific transcriptional responses to hepatotoxicants is lost in the averages of bulk RNA-sequencing (RNA-seq). Single-cell/nuclei RNA-seq technologies enable the transcriptomes of individual cell (sub)ty
Externí odkaz:
https://doaj.org/article/4d0bc72997e944adb26d2a828d699443
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)
Abstract Aryl hydrocarbon receptor (AhR) activation is reported to alter the hepatic expression of circadian clock regulators, however the impact on clock-controlled metabolism has not been thoroughly investigated. This study examines the effects of
Externí odkaz:
https://doaj.org/article/9a17274562514ae6a763ae55659ce0bb
Autor:
Kelly A. Fader, Rance Nault, Chen Zhang, Kazuyoshi Kumagai, Jack R. Harkema, Timothy R. Zacharewski
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Abstract 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant which elicits hepatotoxicity through activation of the aryl hydrocarbon receptor (AhR). Male C57BL/6 mice orally gavaged with TCDD (0.01–30 µg/kg) every
Externí odkaz:
https://doaj.org/article/dfa70fdef3ce4540b2a3007793bde343
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184842 (2017)
The aryl hydrocarbon receptor (AhR) is a highly conserved transcription factor that mediates a broad spectrum of species-, strain-, sex-, age-, tissue-, and cell-specific responses elicited by structurally diverse ligands including 2,3,7,8-tetrachlor
Externí odkaz:
https://doaj.org/article/dbd8a85c60a54f1eac7bb719e66ae799
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 147-159 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 147-159 (2021)
Background and Aims Characterization of cell specific transcriptional responses to hepatotoxicants is lost in the averages of bulk RNA-sequencing (RNA-seq). Single-cell/nuclei RNA-seq technologies enable the transcriptomes of individual cell (sub)typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ab843f37831c05415f5df24a1352ad
https://doi.org/10.1016/j.jcmgh.2020.07.012
https://doi.org/10.1016/j.jcmgh.2020.07.012
Autor:
Jiangwei Zhang, Kelly A. Fader, Shashi K. Ramaiah, Gary S. Friedman, Ravi Thadhani, Elliott M. Antman, Joseph P. Menetski, Vishal S. Vaidya
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics
Faced with the health and economic consequences of the global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the biomedical community came together to identify, diagnose, prevent, and treat the novel disease at breathtaking s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478ff5ea5a12c86fe82000f20ca853b8
https://doi.org/10.1124/jpet.120.000204
https://doi.org/10.1124/jpet.120.000204
Autor:
Kelly A. Fader, Ingrid D. Pardo, Ramesh C. Kovi, Christopher J. Somps, Helen Hong Wang, Vishal S. Vaidya, Shashi K. Ramaiah, Madhu P. Sirivelu
Adeno-associated virus (AAV)-induced dorsal root ganglia (DRG) toxicity has been observed in several nonclinical species, where lesions are characterized by neuronal degeneration/necrosis, nerve fiber degeneration, and mononuclear cell infiltration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3887d189c54e6f093f86109ff2fb660f
https://doi.org/10.1101/2021.12.23.473896
https://doi.org/10.1101/2021.12.23.473896
