Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kelly Locke"'
Autor:
Vinod Sundaramoorthy, Diane Green, Kelly Locke, Carmel M O'Brien, Megan Dearnley, John Bingham
Publikováno v:
PLoS Pathogens, Vol 16, Iss 2, p e1008343 (2020)
Neurotropic viral infections continue to pose a serious threat to human and animal wellbeing. Host responses combatting the invading virus in these infections often cause irreversible damage to the nervous system, resulting in poor prognosis. Rabies
Externí odkaz:
https://doaj.org/article/cac4c1898fe14465b338943b149d8af7
Autor:
Megan Dearnley, Vinod Sundaramoorthy, Kelly Locke, Diane Green, Carmel M. O’Brien, John Bingham
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 2, p e1008343 (2020)
PLoS Pathogens, Vol 16, Iss 2, p e1008343 (2020)
Neurotropic viral infections continue to pose a serious threat to human and animal wellbeing. Host responses combatting the invading virus in these infections often cause irreversible damage to the nervous system, resulting in poor prognosis. Rabies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f374962d13b8f0cb105e3419bb68f812
https://pubmed.ncbi.nlm.nih.gov/32069324
https://pubmed.ncbi.nlm.nih.gov/32069324
Autor:
Andrew D. Roberts, Peter Francis, Paola Grandi, Emma J. Jones, David P. Dixon, Robert J. Watson, Christina Rau, Peter Pogány, Angela Bridges, Chun-wa Chung, Darren Jason Mitchell, Rab K. Prinjha, Peter D. Craggs, Kelly Locke, Emmanuel Hubert Demont, Anne-Marie Michon, Bhumika Karamshi, Rebecca C. Furze, Paul Bamborough, Robert J. Sheppard, Simon C. C. Lucas, Ana Maria Roa
Publikováno v:
Journal of medicinal chemistry. 62(16)
The bromodomain of ATAD2 has proved to be one of the least-tractable proteins within this target class. Here, we describe the discovery of a new class of inhibitors by high-throughput screening and show how the difficulties encountered in establishin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f80874ffd274bf81cab3a201c3f2f1c
https://pubmed.ncbi.nlm.nih.gov/31398032
https://pubmed.ncbi.nlm.nih.gov/31398032
Autor:
Robert P. Davis, Kelly Locke, Rab K. Prinjha, Peter D. Craggs, Gang Yao, Chun-wa Chung, Kenneth E Lind, Oxana Polyakova, Jim E Coote, Daniel J. Slade, Jim Thorpe, John Liddle, David Matthew Wilson, Benjamin D. Bax, Denisa D. Wagner, Kimberly Martinod, Ryan P. Bingham, Yu Hua Chen, Kevin L. Bicker, Claire Maller, Matthew Campbell, Gerard Joberty, Huw D. Lewis, Dirk Eberhard, Martin Rüdiger, Gerard Drewes, Paul R. Thompson, Cecil E Rise, Robert J. Sheppard, Chris Patten, Stephen John Atkinson, Michael David Barker, Pamela Thomas
Publikováno v:
Nature chemical biology
PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases through clinical genetics and gene disruption in mice. New selective PAD4 inhibitors binding a calcium-deficient form of the PAD4 enzyme have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf0de94c1b2987c42df9e5a113919ce
https://doi.org/10.1038/nchembio.1735
https://doi.org/10.1038/nchembio.1735
Autor:
Andrew D. Roberts, Bhumika Karamshi, Angela Bridges, Hawa Diallo, Chun-wa Chung, Kelly Locke, Peter D. Craggs, Darren Jason Mitchell, Paul Bamborough, Amanda Emmons, Christopher Roland Wellaway, Emma J. Jones, David P. Dixon, Robert J. Watson, Nathalie Barrett, Emmanuel Hubert Demont, Clement Douault, Robert J. Sheppard, Rab K. Prinjha, Rebecca C. Furze, Anne-Marie Michon, Paola Grandi, Bernadette Mouzon
Publikováno v:
Journal of medicinal chemistry. 58(14)
Overexpression of ATAD2 (ATPase family, AAA domain containing 2) has been linked to disease severity and progression in a wide range of cancers, and is implicated in the regulation of several drivers of cancer growth. Little is known of the dependenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb3845b766f600c6cb136aa5e1eb88a
https://pubmed.ncbi.nlm.nih.gov/26155854
https://pubmed.ncbi.nlm.nih.gov/26155854
Autor:
Motoko Koyama, Melody Cheong, Kate Markey, Kate Gartlan, Rachel Kuns, Kelly Locke, Katie Lineburg, Bianca Teal, Mark Bunting, Slavica Vuckovic, Ping Zhang, Michele Teng, Antiopi Varelias, Siok-Keen Tey, Leesa Wockner, Christian Engwerda, Mark Smyth, Gabrielle Belz, Shaun McColl, Kelli MacDonald, Geoffrey Hill
Publikováno v:
The Journal of Immunology. 194:140.20-140.20
The spatial and temporal nature of donor antigen presentation during graft-versus-host disease (GVHD) and its relevance to disease severity are poorly understood. Here we use luciferase expressing TCR transgenic CD4+ T cells specific for indirect all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a99c20f34383cf456614a0a57837cb6d
https://doi.org/10.4049/jimmunol.194.supp.140.20
https://doi.org/10.4049/jimmunol.194.supp.140.20
Autor:
Emmanuel H. Demont, Chun-wa Chung, RebeccaC. Furze, Paola Grandi, Anne-Marie Michon, Chris Wellaway, Nathalie Barrett, Angela M. Bridges, PeterD. Craggs, Hawa Diallo, David P. Dixon, Clement Douault, Amanda J. Emmons, EmmaJ. Jones, Bhumika V. Karamshi, Kelly Locke, Darren J. Mitchell, BernadetteH. Mouzon, Rab K. Prinjha, Andy D. Roberts
Publikováno v:
Journal of Medicinal Chemistry; Jul2015, Vol. 58 Issue 14, p5649-5673, 25p
Autor:
Kelly Locke, Jim Nelson
Publikováno v:
The Physics Teacher. 22:256-257
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6574a9553ba07f870493711c28fea00a
https://doi.org/10.1119/1.2341535
https://doi.org/10.1119/1.2341535