1002 Single cell transcriptomics in kidney tissue from African American patients enrolled in the accelerating medicines partnership (AMP) implicates tubular cells in the pathogenesis of APOL1 associated lupus nephritis

Autor: Richard Furie, Brad Rovin, Michelle Petri, Judith A James, Kenneth Kalunian, Maria Dall’Era, Jill Buyon, Chaim Putterman, Peter Izmirly, Betty Diamond, David Wofsy, Ming Wu, Soumya Raychaudhuri, Philip M Carlucci, Qian Xiao, Nir Hacohen, Jennifer Anolik, H Michael Belmont, Robert Clancy, Kelly Ruggles, ANNE DAVIDSON, Deepak Rao, Celine C Berthier, Andrea Fava, Diane Kamen, Joel Guthridge, Arnon Arazi, Jose Monroy-Trujillo, Kristin Haag, William Apruzzese, Fernanda Payan-Schober, Kerry Cho, Joseph Mears, Wade DeJager, Paul Hoover, Kristina Deonaraine, Siddarth Gurajala, Derek Fine, Devyn Zaminski, Jasmine Shwetar, Katie Preisinger, Sethu Madhavan

Publikováno v: Lupus Science and Medicine, Vol 11, Iss Suppl 2 (2024)

Externí odkaz: https://doaj.org/article/e2c9afb65b3c4726a99985adb023a8dc

Risk factors, transcriptomics, and outcomes of myocardial injury following lower extremity revascularization

Autor: Nathaniel R. Smilowitz, MacIntosh Cornwell, Erik J. Offerman, Caron B. Rockman, Svati H. Shah, Jonathan D. Newman, Kelly Ruggles, Deepak Voora, Jeffrey S. Berger

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract Myocardial injury after non-cardiac surgery (MINS) is common. We investigated the incidence and outcomes of MINS, and mechanistic underpinnings using pre-operative whole blood gene expression profiling in a prospective cohort study of indivi

Externí odkaz: https://doaj.org/article/22f0d535d13a4dcba54163ced36bd594

Spatially interacting phosphorylation sites and mutations in cancer

Autor: Kuan-lin Huang, Adam D. Scott, Daniel Cui Zhou, Liang-Bo Wang, Amila Weerasinghe, Abdulkadir Elmas, Ruiyang Liu, Yige Wu, Michael C. Wendl, Matthew A. Wyczalkowski, Jessika Baral, Sohini Sengupta, Chin-Wen Lai, Kelly Ruggles, Samuel H. Payne, Benjamin Raphael, David Fenyö, Ken Chen, Gordon Mills, Li Ding

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Dysregulated phosphorylation is well-known in cancers, but it has largely been studied in isolation from mutations. Here the authors introduce HotPho, a tool that can discover spatial interactions between phosphosites and mutations, which are associa

Externí odkaz: https://doaj.org/article/f38865e7329d4929ad5179de6e149dde

Effects of early-life penicillin exposure on the gut microbiome and frontal cortex and amygdala gene expression

Autor: Angelina Volkova, Kelly Ruggles, Anjelique Schulfer, Zhan Gao, Stephen D. Ginsberg, Martin J. Blaser

Publikováno v: iScience, Vol 24, Iss 7, Pp 102797- (2021)

Summary: We have established experimental systems to assess the effects of early-life exposures to antibiotics on the intestinal microbiota and gene expression in the brain. This model system is highly relevant to human exposure and may be developed

Externí odkaz: https://doaj.org/article/b675822e3d784ce29ade66c90c63d5db

Integrated Proteomic and Glycoproteomic Characterization of Human High-Grade Serous Ovarian Carcinoma

Autor: Yingwei Hu, Jianbo Pan, Punit Shah, Minghui Ao, Stefani N. Thomas, Yang Liu, Lijun Chen, Michael Schnaubelt, David J. Clark, Henry Rodriguez, Emily S. Boja, Tara Hiltke, Christopher R. Kinsinger, Karin D. Rodland, Qing Kay Li, Jiang Qian, Zhen Zhang, Daniel W. Chan, Hui Zhang, Akhilesh Pandey, Amanda Paulovich, Andrew Hoofnagle, Bing Zhang, D.R. Mani, Daniel C. Liebler, David F. Ransohoff, David Fenyo, David L. Tabb, Douglas A. Levine, Eric Kuhn, Forest M. White, Gordon A. Whiteley, Heng Zhu, Ie-Ming Shih, Jasmin Bavarva, Jason E. McDermott, Jeffrey Whiteaker, Karen A. Ketchum, Karl R. Clauser, Kelly Ruggles, Kimberly Elburn, Li Ding, Linda Hannick, Lisa J. Zimmerman, Mark Watson, Mathangi Thiagarajan, Matthew J.C. Ellis, Mauricio Oberti, Mehdi Mesri, Melinda E. Sanders, Melissa Borucki, Michael A. Gillette, Michael Snyder, Nathan J. Edwards, Negin Vatanian, Paul A. Rudnick, Peter B. McGarvey, Philip Mertins, R. Reid Townsend, Ratna R. Thangudu, Richard D. Smith, Robert C. Rivers, Robert J.C. Slebos, Samuel H. Payne, Sherri R. Davies, Shuang Cai, Stephen E. Stein, Steven A. Carr, Steven J. Skates, Subha Madhavan, Tao Liu, Xian Chen, Yingming Zhao, Yue Wang, Zhiao Shi

Publikováno v: Cell Reports, Vol 33, Iss 3, Pp 108276- (2020)

Summary: Many gene products exhibit great structural heterogeneity because of an array of modifications. These modifications are not directly encoded in the genomic template but often affect the functionality of proteins. Protein glycosylation plays

Externí odkaz: https://doaj.org/article/687878b78b8f4a70bfe6276db55dbef8