Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

Autor: Laura E. de Vries, Patrick A. M. Jansen, Catalina Barcelo, Justin Munro, Julie M. J. Verhoef, Charisse Flerida A. Pasaje, Kelly Rubiano, Josefine Striepen, Nada Abla, Luuk Berning, Judith M. Bolscher, Claudia Demarta-Gatsi, Rob W. M. Henderson, Tonnie Huijs, Karin M. J. Koolen, Patrick K. Tumwebaze, Tomas Yeo, Anna C. C. Aguiar, Iñigo Angulo-Barturen, Alisje Churchyard, Jake Baum, Benigno Crespo Fernández, Aline Fuchs, Francisco-Javier Gamo, Rafael V. C. Guido, María Belén Jiménez-Diaz, Dhelio B. Pereira, Rosemary Rochford, Camille Roesch, Laura M. Sanz, Graham Trevitt, Benoit Witkowski, Sergio Wittlin, Roland A. Cooper, Philip J. Rosenthal, Robert W. Sauerwein, Joost Schalkwijk, Pedro H. H. Hermkens, Roger V. Bonnert, Brice Campo, David A. Fidock, Manuel Llinás, Jacquin C. Niles, Taco W. A. Kooij, Koen J. Dechering

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Here, de Vries et al. perform a pre-clinical characterization of the antimalarial compound MMV693183: the compound targets acetyl-CoA synthetase, has efficacy in humanized mice against Plasmodium falciparum infection, blocks transmission to mosquito

Externí odkaz: https://doaj.org/article/5a569da9aa694e86aa5e04aa0c21ba75

Activation of the Plasmodium egress effector subtilisin-like protease 1 is achieved by plasmepsin X destruction of the propiece

Autor: Sumit Mukherjee, Armiyaw S. Nasamu, Kelly Rubiano, Daniel E. Goldberg

Publikováno v: bioRxiv

Following each round of replication, daughter merozoites of the malaria parasitePlasmodium falciparumescape (egress) from the infected host red blood cell (RBC) by rupturing the parasitophorous vacuole membrane (PVM) and the RBC membrane (RBCM). A pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5233bdad21768a398e159d28d73eda4a
https://europepmc.org/articles/PMC9882241/

Optimization of a Membrane Feeding Assay for Plasmodium vivax Infection in Anopheles albimanus.

Autor: Andrés F Vallejo, Kelly Rubiano, Andres Amado, Amy R Krystosik, Sócrates Herrera, Myriam Arévalo-Herrera

Publikováno v: PLoS Neglected Tropical Diseases, Vol 10, Iss 6, p e0004807 (2016)

INTRODUCTION:Individuals exposed to malaria infections for a long time develop immune responses capable of blocking Plasmodium transmission to mosquito vectors, potentially limiting parasite spreading in nature. Development of a malaria TB vaccine re

Externí odkaz: https://doaj.org/article/b8a00c7ee3fb4cb99f36a6e9828e8121

Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

Autor: Sachel Mok, Adama Gansané, Rithea Leang, Clark H. Cunningham, Romaric Nzoumbou-Boko, David A. Fidock, Aline Uwimana, Ioanna Deni, Nina F. Gnädig, Barbara H. Stokes, Marian Warsame, Kelly Rubiano, Leila S. Ross, Olimatou Kolley, Kurt E. Ward, Issa M. Souleymane, Eric Legrand, Frédéric Ariey, Philip J. Rosenthal, Josefine Striepen, Samuel J. Smith, Abdunoor M. Kabanywanyi, Judith Straimer, Jade Bath, Kyra A Schindler, Didier Menard, Mathieu Ndounga, Tim J. Anderson, François Nosten, Claudette Ndayikunda, Tomas Yeo, Satish K. Dhingra

Publikováno v: eLife, Vol 10 (2021)
eLife
eLife, eLife Sciences Publication, 2021, 10, pp.e66277. ⟨10.7554/eLife.66277⟩
eLife, 2021, 10, pp.e66277. ⟨10.7554/eLife.66277⟩

The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium falciparum malaria parasites has led to widespread treatment failures across Southeast Asia. In Africa, K13-propeller genotyping confirms the emergence of the R561H mutat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d4652f8546d77e0464272dc94dc4b6
https://ora.ox.ac.uk/objects/uuid:24d02c06-c99a-469c-92f8-1d3ccb074394

The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance

Autor: Mohammed H Cherkaoui-Rbati, Roland A. Cooper, Nina F. Gnädig, Iñigo Angulo-Barturen, Tomas Yeo, Sridevi Bashyam, Rintis Noviyanti, James M. Murithi, Gilles Courtemanche, Philip J. Rosenthal, María Belén Jiménez-Díaz, Laurent Sallé, Cécile Pascal, Rita Merino, Gilles Tuffal, Jutta Marfurt, Sergio Wittlin, Shivendra Singh, Marie José Cabanis, Lidiya Bebrevska, Jean Michel Augereau, Laura M. Sanz, Jean Michel Guillon, Sachel Mok, Paul Desert, Kelly Rubiano, Alain Pellet, Jacquin C. Niles, Guillaume Louit, Anne-Catrin Uhlemann, Nadir Bessila, Thierry Vermat, Simon Campbell, Didier Leroy, Tanguy Bozec, Jérôme Menegotto, Michel Doubovetzky, Xavier Boulenc, Benjamin Blasco, Nathalie Gobeau, Francisco-Javier Gamo, Sylvie Klieber, Elie Giraud, Jayan Joseph, Charisse Flerida A. Pasaje, Delphine Baud, Laurent Fraisse, Fanny Escudié, Jade Bath, Marie Françoise Nicolas, Mélanie Rouillier, David A. Fidock, Grennady Wirjanata, Ric N. Price, Patrick K Tumwebaze

The emergence and spread of Plasmodium falciparum resistance to first-line antimalarials creates an imperative to identify and develop potent preclinical candidates with distinct modes of action. Here, we report the identification of MMV688533, an ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c2e27d8190f65306f8587a21d03126
https://ora.ox.ac.uk/objects/uuid:39d2c646-efac-4c3d-bdef-8cf1ff7f497f