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pro vyhledávání: '"Kellsye Fabian"'
Autor:
Jeffrey Schlom, Leisha A Emens, Howard Kaufman, James Hodge, Sailaja Battula, Kellsye Fabian, Ginette Santiago-Sanchez
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/2f3bdd4b422f46a1b187d0fadbd145fe
Autor:
Dalia Raich-Regue, Brian Rosborough, Kellsye Fabian, Heth Turnquist, Walter Storkus, Angus Thomson
Publikováno v:
The Journal of Immunology. 194:141.7-141.7
The mechanistic/mammalian target of rapamycin (mTOR) is a key integrative kinase that functions in at least two independent complexes: mTOR complex (C)1 and mTORC2. While mTORC2 in T cells promotes Th2 differentiation, its immunologic function in den
Autor:
Kellsye Fabian, Walter Storkus
Publikováno v:
The Journal of Immunology. 194:214.11-214.11
The vasculature of solid tumors is essential for their progressive growth and is abnormal structurally and functionally. Notably, pericytes and vascular endothelial cells (VEC) in tumors exhibit altered epigenetic programming and express antigens tha
Publikováno v:
The Journal of Immunology. 192:206.2-206.2
The tumor microenvironment (TME) promotes unique epigenetic programming of stromal cell populations, including vascular endothelial cells (VEC) and pericytes, leading to differential expression of antigens that may be recognized by therapeutic T cell
Publikováno v:
The Journal of Immunology. 190:45.1-45.1
Previous studies suggest that by improving Notch signaling in the tumor microenvironment (TME), one may rescue tumor infiltrating T lymphocyte function and inhibit tumor growth in vivo. Delta-like homolog 1 (DLK-1) and Delta-like homolog 2 (DLK-2) ar