Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kellie M. Regal"'
Publikováno v:
Free Radical Biology and Medicine. 159:S43
Autor:
Danhong Lu, Kellie M. Regal, J. Jason Collier, Michael D. Karlstad, Adrianna E. Eder, David H. Burk, Susan J. Burke
Publikováno v:
BioFactors. 42:703-715
Type 1 diabetes mellitus (T1DM) results from immune cell-mediated reductions in function and mass of the insulin-producing β-cells within the pancreatic islets. While the initial trigger(s) that initiates the autoimmune process is unknown, there is
Autor:
Deniz Peker, Juan Li, Kellie M. Regal, Timothy N. Trotter, Patrick D. Rowan, Amjad Javed, Larry J. Suva, Yang Yang, Qianying Pan
Publikováno v:
Oncotarget
Bone dissemination and bone disease occur in approximately 80% of patients with multiple myeloma (MM) and are a major cause of patient mortality. We previously demonstrated that MM cell-derived heparanase (HPSE) is a major driver of MM dissemination
Autor:
Michael D. Karlstad, Jacqueline M. Stephens, Carrie M. Elks, Danhong Lu, J. Jason Collier, Tim E. Sparer, Kellie M. Regal, David H. Burk, Ryan W. Grant, Susan J. Burke
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1849:637-652
Enhanced leukocytic infiltration into pancreatic islets contributes to inflammation-based diminutions in functional β-cell mass. Insulitis (aka islet inflammation), which can be present in both T1DM and T2DM, is one factor influencing pancreatic β-
Publikováno v:
Chemical research in toxicology. 27(12)
Topoisomerases are essential enzymes that are involved in DNA metabolism. Topoisomerase II generates transient DNA strand breaks that are stabilized by anticancer drugs, such as doxorubicin, causing an accumulation of DNA damage. However, doxorubicin
Publikováno v:
The FASEB Journal. 28
Publikováno v:
Free Radical Biology and Medicine. 100:S150
Monocyte interactions with endothelial cells (ECs) are mediated by N-glycosylated surface adhesion proteins such as intracellular adhesion molecule 1 (ICAM-1). We have previously shown that ICAM-1 is expressed as both a complex N-glycoform as well as
Publikováno v:
Cancer Research. 76:2761-2761
Tyrosyl-DNA phosphodiesterase I (Tdp1) is a highly conserved eukaryotic DNA repair enzyme that catalyzes the resolution of 3’ and 5’ phospho-DNA adducts. Tdp1 has been implicated in the repair of DNA topoisomerase I (Topo1)-DNA covalent complexes