Výsledky vyhledávání - "Kellie Latimer"

CD117 Antibody Drug Conjugate-Based Conditioning Enables Efficient Engraftment of Gene-Modified CD34+ Cells in a Rhesus Gene Therapy Model

Autor: Rahul Palchaudhuri, Naoya Uchida, Ulana Stasula, Malikiya Hinds, Paula Germino-Watnick, Allen E Krouse, Nathaniel Linde, Aylin Bonifacino, Kellie Latimer, Prashant raj Bhattarai, Nicholas C Yoder, Qing Li, Kirk Bertelsen, Lisa M Olson, Robert E. Donahue, John F. Tisdale

Publikováno v: Transplantation and Cellular Therapy. 28:S238

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11e14642961526cbef650f0cabc2a9f0
https://doi.org/10.1016/s2666-6367(22)00465-1

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CD117 Antibody Drug Conjugate-Based Conditioning Allows for Efficient Engraftment of Gene-Modified CD34+ Cells in a Rhesus Gene Therapy Model

Autor: Naoya Uchida, Ulana Stasula, Malikiya Hinds, Paula Germino-Watnick, Allen E. Krouse, N Seth Linde, Aylin C. Bonifacino, Kellie Latimer, Prashant Bhattarai, Nicholas C. Yoder, Rahul Palchaudhuri, Qing Li, Kirk Bertelsen, Lisa Olson, Robert E. Donahue, John F. Tisdale

Publikováno v: Blood. 138:560-560

Hematopoietic stem cell (HSC) gene therapy is now curative for multiple genetic diseases; however, it is limited by morbidity and mortality from cytotoxic chemotherapy-based conditioning. To overcome these limitations, we developed an antibody drug c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01da03f69c24ac8d5a547b8b5a01ba43
https://doi.org/10.1182/blood-2021-145524

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A Single Dose of a Novel Anti-Human CD117-Amanitin Antibody Drug Conjugate (ADC) Engineered for a Short Half-Life Provides Dual Conditioning and Anti-Leukemia Activity and Extends Survival Compared to Standard of Care in Multiple Preclinical Models of Acute Myeloid Leukemia (AML)

Autor: Oliver Mikse, Tahirih L. Lamothe, Lisa M Olson, Nidhi Jain, Jennifer L. Proctor, Ryan Knihtila, Sean McDonough, John C. Davis, Anthony E. Boitano, Rahul Palchaudhuri, Michael P. Cooke, Ganapathy N. Sarma, Bradley R. Pearse, Prashant raj Bhattarai, Leanne Lanieri, Junia Dushime, Kellie Latimer

Publikováno v: Transplantation and Cellular Therapy. 27:S49-S50

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1be6db879b36491aaefce34d13b1d033
https://doi.org/10.1016/s2666-6367(21)00079-8

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A Single Dose of a Novel Anti-Human CD117-Amanitin Antibody Drug Conjugate (ADC) Engineered for a Short Half-Life Provides Dual Conditioning and Anti-Leukemic Activity and Extends Survival Compared to Standard of Care in Multiple Preclinical Models of Acute Myeloid Leukemia (AML)

Autor: Ryan Knihtila, Michael P. Cooke, Tahirih L. Lamothe, Leanne Lanieri, Sean McDonough, Anthony E. Boitano, Prashant raj Bhattarai, John C. Davis, Rahul Palchaudhuri, Junia Dushime, Jennifer L. Proctor, Oliver Miske, Nidhi Jain, Ganapathy N. Sarma, Bradley R. Pearse, Kellie Latimer

Publikováno v: Blood. 136:47-48

Hematopoietic stem cell transplant (HSCT) can be a highly effective, and often curative, treatment for patients with AML. At present, myeloablative conditioning (MAC) regimens are associated with severe acute and long-term toxicities. A subset of tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ff725b3a25ef027eac59dbe5dd4c3b7
https://doi.org/10.1182/blood-2020-140422

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A Non-Genotoxic Anti-CD117 Antibody Drug Conjugate (ADC) Designed for Patient Conditioning Prior to Stem Cell Transplant and HSC-Based Gene Therapy Has a Broad Therapeutic Window across Species

Autor: Rahul Palchaudhuri, Junia Dushime, Jason Neale, Ganapathy N. Sarma, Bradley R. Pearse, Melissa L. Brooks, Charlotte Mcdonagh, Jennifer L. Proctor, Anthony E. Boitano, Tahirih L. Lamothe, Ryan Knihtila, Nidhi Jain, Rajiv Panwar, Qing Li, Sean McDonough, John C. Davis, Michael P. Cooke, Lena Kien, Kellie Latimer

Publikováno v: Biology of Blood and Marrow Transplantation. 26:S35-S36

Current approaches to conditioning prior to transplant and gene therapy employ non-specific genotoxic agents that are associated with severe acute and long-term toxicities. Consequently, many transplant eligible patients either refuse transplant or r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96d9226718ce75670ce92b5fbdaddf92
https://doi.org/10.1016/j.bbmt.2019.12.580

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A Single Dose of CD117 Antibody Drug Conjugate Enables Hematopoietic Stem Cell Based Gene Therapy in Nonhuman Primates

Publikováno v: Biology of Blood and Marrow Transplantation. 26:S6

Autologous hematopoietic stem cell transplantation (Auto-HSCT) with gene-modification represents a potential cure for multiple genetic diseases, but its broad curative potential, is limited because of morbidity/mortality from cytotoxic chemotherapy-b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8d3569844a1ea5cd7ba4764b26efd6a
https://doi.org/10.1016/j.bbmt.2019.12.139

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A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates

Publikováno v: Blood. 134:610-610

Autologous hematopoietic stem cell transplantation (Auto-HSCT) with gene-modification techniques represents a potential cure for multiple genetic blood diseases. Despite its broad curative potential, auto-gene modified HSCT is currently limited due t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c85d730680d91f633de1b2fac6f26e2
https://doi.org/10.1182/blood-2019-125968

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