Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kelli P.A. Macdonald"'
Autor:
Kate H. Gartlan, Motoko Koyama, Katie E. Lineburg, Karshing Chang, Kathleen S. Ensbey, Rachel D. Kuns, Andrea S. Henden, Luke D. Samson, Andrew D. Clouston, Angel F. Lopez, Kelli P.A. MacDonald, Geoffrey R. Hill
Publikováno v:
Blood Advances, Vol 3, Iss 19, Pp 2859-2865 (2019)
Abstract: Granulocyte-macrophage colony-stimulating factor (GM-CSF) has recently emerged as an important pathogenic cytokine in acute graft-versus-host disease (GVHD), but the nature of the T-cell lineages secreting the cytokine and the mechanisms of
Externí odkaz:
https://doaj.org/article/d76e1a4d6bf14802a597a6f718045478
Autor:
Kate H. Gartlan, Antiopi Varelias, Motoko Koyama, Renee J. Robb, Kate A. Markey, Karshing Chang, Andrew N. Wilkinson, David Smith, Md Ashik Ullah, Rachel D. Kuns, Neil C. Raffelt, Stuart D. Olver, Katie E. Lineburg, Bianca E. Teal, Melody Cheong, Michele W.L. Teng, Mark J. Smyth, Siok-Keen Tey, Kelli P.A. MacDonald, Geoffrey R. Hill
Publikováno v:
Blood Advances, Vol 1, Iss 6, Pp 341-351 (2017)
Abstract: T-helper 17 (Th17) cells have been widely implicated as drivers of autoimmune disease. In particular, Th17 cytokine plasticity and acquisition of an interleukin-17A+(IL-17A+)interferon γ(IFNγ)+ cytokine profile is associated with increase
Externí odkaz:
https://doaj.org/article/df05b8e5031c4704855ef42d306ae5c3
Autor:
Amy H. Porter, Lucie Leveque-El Mouttie, Therese Vu, Claudia Bruedigam, Joanne Sutton, Sebastien Jacquelin, Geoffrey R. Hill, Kelli P.A. MacDonald, Steven W. Lane
Publikováno v:
Haematologica, Vol 102, Iss 9 (2017)
Externí odkaz:
https://doaj.org/article/bfb6216dd8994ece9bc46fc67309fdeb
Autor:
Joshua M. Horne-Debets, Rebecca Faleiro, Deshapriya S. Karunarathne, Xue Q. Liu, Katie E. Lineburg, Chek Meng Poh, Gijsbert M. Grotenbreg, Geoffrey R. Hill, Kelli P.A. MacDonald, Michael F. Good, Laurent Renia, Rafi Ahmed, Arlene H. Sharpe, Michelle N. Wykes
Publikováno v:
Cell Reports, Vol 5, Iss 5, Pp 1204-1213 (2013)
Malaria is a highly prevalent disease caused by infection by Plasmodium spp., which infect hepatocytes and erythrocytes. Blood-stage infections cause devastating symptoms and can persist for years. Antibodies and CD4+ T cells are thought to protect a
Externí odkaz:
https://doaj.org/article/de2b1619a7bb43b6a304a38cc0647a8d
Autor:
Geoffrey D.E. Cuvelier, Michelle Schoettler, Nataliya P. Buxbaum, Iago Pinal-Fernandez, Marc Schmalzing, Jörg H.W. Distler, Olaf Penack, Bianca D. Santomasso, Robert Zeiser, Klemens Angstwurm, Kelli P.A. MacDonald, W. Taylor Kimberly, Naomi Taylor, Ervina Bilic, Bernhard Banas, Maike Buettner-Herold, Namita Sinha, Hildegard T. Greinix, Joseph Pidala, Kirk R. Schultz, Kirsten M. Williams, Yoshihiro Inamoto, Corey Cutler, Linda M. Griffith, Stephanie J. Lee, Stefanie Sarantopoulos, Steven Z. Pavletic, Daniel Wolff
Publikováno v:
Transplantation and Cellular Therapy. 28:426-445
Alloreactive and autoimmune responses after allogeneic hematopoietic cell transplantation can occur in nonclassical chronic graft-versus-host disease (chronic GVHD) tissues and organ systems or manifest in atypical ways in classical organs commonly a
Autor:
Geoffrey R. Hill, Motoko Koyama, Mariapia A. Degli-Esposti, Joseph A. Trapani, Kelli P.A. MacDonald, Christian R. Engwerda, Mark J. Smyth, Glen M. Boyle, Kate A. Markey, Slavica Vuckovic, Antiopi Varelias, Greg Kelly, Vivien R. Sutton, Karshing Chang, Jose Paulo Martins, Christopher E. Andoniou, Rachel D. Kuns, Ping Zhang, Siok-Keen Tey, Jason S. Lee, Kate H. Gartlan, Melody Cheong
Supplementary Figure S1: GVHD survival of lethally-irradiated (day 0, 1000cGy split dose) B6.WT, B6.ASC-/- or B6.NLRP3-/- recipients transplanted with BALB/c BM (5x106) and T cells (5x106). The non-GVHD control group received TCD BM cells (5x106) onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c670406bdd6e90ec2d85cea9452ca1
https://doi.org/10.1158/2326-6066.22543108
https://doi.org/10.1158/2326-6066.22543108
Autor:
Geoffrey R. Hill, Motoko Koyama, Mariapia A. Degli-Esposti, Joseph A. Trapani, Kelli P.A. MacDonald, Christian R. Engwerda, Mark J. Smyth, Glen M. Boyle, Kate A. Markey, Slavica Vuckovic, Antiopi Varelias, Greg Kelly, Vivien R. Sutton, Karshing Chang, Jose Paulo Martins, Christopher E. Andoniou, Rachel D. Kuns, Ping Zhang, Siok-Keen Tey, Jason S. Lee, Kate H. Gartlan, Melody Cheong
The adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD) is known to facilitate caspase-1 activation, which is essential for innate host immunity via the formation of the inflammasome complex, a multiprotein structure respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7145b9fd80a40cc0741b069c6d960d1
https://doi.org/10.1158/2326-6066.c.6550138.v1
https://doi.org/10.1158/2326-6066.c.6550138.v1
Autor:
Geoffrey R. Hill, Motoko Koyama, Mariapia A. Degli-Esposti, Joseph A. Trapani, Kelli P.A. MacDonald, Christian R. Engwerda, Mark J. Smyth, Glen M. Boyle, Kate A. Markey, Slavica Vuckovic, Antiopi Varelias, Greg Kelly, Vivien R. Sutton, Karshing Chang, Jose Paulo Martins, Christopher E. Andoniou, Rachel D. Kuns, Ping Zhang, Siok-Keen Tey, Jason S. Lee, Kate H. Gartlan, Melody Cheong
Supplementary Table S1 (related to Fig. 4A): (A) Ingenuity Pathway Analysis derived from the uncorrected dataset displaying top canonical signaling pathways involving differentially regulated genes in recipients as described in Fig.4A. (B) 10 selecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b81f04af8f07416c8522368ebdbf6e4
https://doi.org/10.1158/2326-6066.22543105.v1
https://doi.org/10.1158/2326-6066.22543105.v1
Autor:
Jemma H. Larson, Sujeong Jin, Michael Loschi, Sara Bolivar Wagers, Govindarajan Thangavelu, Michael C. Zaiken, Cameron McDonald-Hyman, Asim Saha, Ethan G. Aguilar, Brent Koehn, Mark J. Osborn, Angela Panoskaltsis-Mortari, Kelli P.A. Macdonald, Geoffrey R. Hill, William J. Murphy, Jonathan S. Serody, Ivan Maillard, Leslie S. Kean, Sangwon V. Kim, Dan R. Littman, Bruce R. Blazar
Publikováno v:
American Journal of Transplantation.
Autor:
Jemma H Nicholls, Michael Loschi, Sujeong Jin, Sara Bolivar Wagers, Govindarajan Thangavelu, Michael C Zaiken, Cameron McDonald-Hyman, Asim Saha, Ethan G Aguliar, Brent Koehn, Mark J Osborn, Kelli P.A. MacDonald, Sangwon V Kim, Dan R Littman, Bruce R Blazar
Publikováno v:
The Journal of Immunology. 206:11.05-11.05
Damage to the gastrointestinal (GI) tract following hematopoietic stem cell transplant (HSCT) has been shown to drive the development of acute graft-versus-host disease (aGVHD). We have demonstrated clinically that infusing regulatory T-cells (Treg)