Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kelli MacDonald"'
Autor:
Alexandra Zanin-Zhorov, Wei Chen, Julien Moretti, Melanie S. Nyuydzefe, Iris Zhorov, Rashmi Munshi, Malavika Ghosh, Cindy Serdjebi, Kelli MacDonald, Bruce R. Blazar, Melissa Palmer, Samuel D. Waksal
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract The pathogenesis of hepatic fibrosis is driven by dysregulated metabolism precipitated by chronic inflammation. Rho-associated coiled-coil-containing protein kinases (ROCKs) have been implicated in these processes, however the ability of sel
Externí odkaz:
https://doaj.org/article/1360ef435b4a4bcb8e0d0bb6c03f33cd
Autor:
Christos Xiao, Mariska Miranda, Wei Shi, Jonathan Beesley, Jodi M. Saunus, Andrew Civitarese, Debra M. Black, Meagan Ruppert, Melrine Pereira, Susan Jackson, Zachary Teale, Dylan Carter-Cusack, Lauren Kalinowski, Jamie R. Kutasovic, Amy E. McCart Reed, Herlina Y. Handoko, XiaoQing Chen, Darrell Bessette, Kelli MacDonald, Sunil R. Lakhani, Georgia Chenevix-Trench, Kara Britt, Fares Al-Ejeh
BackgroundGenome-wide association studies have identified a breast cancer risk locus at 19q13.31. The candidate causal variants at this locus are located in the first exon ofKCNN4.KCNN4, which regulates membrane potential and Ca2+signaling, is a good
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21c8cc28c52b9353dcff96e792037d73
https://doi.org/10.1101/2023.04.25.538345
https://doi.org/10.1101/2023.04.25.538345
Autor:
Alexandra Zanin-Zhorov, Wei Chen, Melanie Nyuydzefe, Julien Moretti, Iris Zhorov, Rashmi Munshi, Malavika Ghosh, Kelli MacDonald, Bruce Blazar, Sam Waksal
Publikováno v:
Journal of Hepatology. 77:S494-S495
Autor:
Michael C Zaiken, Ryan Flynn, Katelyn Paz, Stephanie Rhee, Paul Park, Matthew Hemming, Peter Sage, Arlene Sharpe, Leonard Luznik, Ivan Mailard, Geoffrey R. Hill, Kelli MacDonald, Jonathon Serody, Corey Cutler, John Koreth, David Miklos, Joseph Antin, Robert Soiffer, Jerome Ritz, Jay Bradner, Jun Qi, Bruce R. Blazar
Publikováno v:
The Journal of Immunology. 202:69.42-69.42
To determine whether targeting EZH2, a histone methyltransferase necessary for germinal center (GC) formation, could reduce murine cGVHD (cGVHD), we first used a clinically relevant murine model of cGVHD, which recapitulates multi-organ cGVHD with br
Autor:
Gheath Alatrash, Maite Alvarez, Claudio Anasetti, Bruce R. Blazar, Craig A. Byersdorfer, Dominique Charron, Xiao Chen, James M. Coghill, Kenneth R. Cooke, William R. Drobyski, Jarrod A. Dudakov, Matthias Edinger, James L.M. Ferrara, Bree Foley, Daniel H. Fowler, Els Goulmy, Alan M. Hanash, Gerhard C. Hildebrandt, Geoffrey R. Hill, Petra Hoffmann, E. Holler, Caron A. Jacobson, Dennis B. Leveson-Gower, Robert B. Levy, Kelli MacDonald, Kate A. Markey, Paul J. Martin, Jeffrey S. Miller, Jeffrey J. Molldrem, William Murphy, Tuna Mutis, Robert S. Negrin, Sophie Paczesny, Olaf Penack, Miguel-Angel Perales, Effie Petersdorf, Pavan Reddy, Jerome Ritz, Jonathan S. Serody, Warren D. Shlomchik, Gérard Socié, R. Storb, Yaping Sun, Marcel van den Brink, Christian A. Wysocki, Xue-Zhong Yu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a023584d7fac71e58d366133b0c25a63
https://doi.org/10.1016/b978-0-12-416004-0.01002-8
https://doi.org/10.1016/b978-0-12-416004-0.01002-8
Autor:
Melody Cheong, Kate Gartlan, Siok-Keen Tey, Rachel Kuns, Mary Lor, Katie Lineburg, Bianca Teal, Wei Shi, Jyothy Raju, Ping Zhang, Antiopi Varelias, Lucie Leveque-El Mouttie, Stuart Olver, Mark Bunting, Steven Lane, Glen Boyle, Jenny Ting, Kate Schroder, Christian Engwerda, Kum Kum Khanna, Mark Smyth, Kelli MacDonald, Motoko Koyama, Geoffrey Hill
Publikováno v:
The Journal of Immunology. 194:140.33-140.33
The adaptor protein ASC is known to facilitate caspase-1 activation essential for innate host immunity via the formation of the inflammasome complex - a multi-protein structure responsible for processing IL-1b and IL-18 to their active moieties. Here
Autor:
Motoko Koyama, Melody Cheong, Kate Markey, Kate Gartlan, Rachel Kuns, Kelly Locke, Katie Lineburg, Bianca Teal, Mark Bunting, Slavica Vuckovic, Ping Zhang, Michele Teng, Antiopi Varelias, Siok-Keen Tey, Leesa Wockner, Christian Engwerda, Mark Smyth, Gabrielle Belz, Shaun McColl, Kelli MacDonald, Geoffrey Hill
Publikováno v:
The Journal of Immunology. 194:140.20-140.20
The spatial and temporal nature of donor antigen presentation during graft-versus-host disease (GVHD) and its relevance to disease severity are poorly understood. Here we use luciferase expressing TCR transgenic CD4+ T cells specific for indirect all
Autor:
Alexandra Zanin-Zhorov, Ryan Flynn, Leo Luznik, melanie Nyuydzefe, Angela Panoskaltsis-Mortari, Jing Du, Katelyn Goodman, Jonathan Weiss, Wei Chen, Jonathan Serody, Kelli MacDonald, Geoffrey Hill, John O'Shea, Samuel Waksal, Bruce Blazar
Publikováno v:
The Journal of Immunology. 194:140.15-140.15
Rho-associated kinase 2 (ROCK2) was recently shown to be implicated in regulation of IL-21 and IL-17 secretion in mice and humans. Here, we report that the potent and highly selective ROCK2 inhibitor KD025 effectively reverses an established chronic
Publikováno v:
Europe PubMed Central
The MUC1 mucin (CD227) is a cell surface mucin originally thought to be restricted to epithelial tissues. We report that CD227 is expressed on human blood dendritic cells (DC) and monocyte-derived DC following in vitro activation. Freshly isolated mu
Autor:
Kate Markey, Motoko Koyama, Kate Gartlan, Lucie Leveque, Rachel Kuns, Katie Lineburg, Bianca Teal, Kelli MacDonald, Geoff Hill
Publikováno v:
The Journal of Immunology. 192:202.42-202.42
The role of trogocytosis in generating naïve T cell responses is controversial and highly relevant to transplantation. We transplanted B6.CD11cGFP donor bone marrow (BM) grafts (H2Db, IAb, GFP off the CD11c promoter) into irradiated B6D2F1 (H2Db/d,