Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kelli L. Vaughan"'
Autor:
Hagai Yanai, Bongsoo Park, Hyunwook Koh, Hyo Jung Jang, Kelli L. Vaughan, Mayuri Tanaka-Yano, Miguel Aon, Madison Blanton, Ilhem Messaoudi, Alberto Diaz-Ruiz, Julie A. Mattison, Isabel Beerman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Dietary restriction has shown benefits in physiological, metabolic, and molecular signatures associated with aging but is a difficult lifestyle to maintain for most individuals. In mice, a less restrictive diet that allows for cyclical perio
Externí odkaz:
https://doaj.org/article/db9957647c4c41dba19b324fff38ec43
Autor:
Michael B. Stout, Kelli L. Vaughan, Jose V. V. Isola, Shivani N. Mann, Bayli Wellman, Jessica M. Hoffman, Hunter L. Porter, Willard M. Freeman, Julie A. Mattison
Publikováno v:
GeroScience.
Autor:
Tae-Hoon Shin, Yifan Zhou, Shirley Chen, Stefan Cordes, Max Z. Grice, Xing Fan, Byung-Chul Lee, Aisha A. Aljanahi, So Gun Hong, Kelli L. Vaughan, Julie A. Mattison, Steven G. Kohama, Margarete A. Fabre, Naoya Uchida, Selami Demirci, Marcus A.F. Corat, Jean-Yves Métais, Katherine R. Calvo, Manuel Buscarlet, Hannah Natanson, Kathy L. McGraw, Alan F. List, Lambert Busque, John F. Tisdale, George S. Vassiliou, Kyung-Rok Yu, Cynthia E. Dunbar
Publikováno v:
Blood. 140(16)
Individuals with age-related clonal hematopoiesis (CH) are at greater risk for hematologic malignancies and cardiovascular diseases. However, predictive preclinical animal models to recapitulate the spectrum of human CH are lacking. Through error-cor
Autor:
Julie A. Mattison, Nigel H. Greig, Dong Seok Kim, Ho-Il Choi, Hee Kyung Kim, Kelli L. Vaughan, David Tweedie, Yazhou Li, Jin Jung
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
The time-dependent (30 min - day 84) plasma profile of PT320, a sustained-release (SR)-Exenatide formulation under clinical development for treatment of neurodegenerative disorders, was evaluated in nonhuman primates after a single subcutaneous dose
Autor:
Amy C. Rothwell, Zhan-Guo Gao, Julie A. Mattison, Philip Z. Mannes, Zhenzhong Cui, Harsha Rao, Marc L. Reitman, Oksana Gavrilova, Antonella Ciancetta, Amelia Bitant, Kelli L. Vaughan, Veronica Salmaso, Kenneth A. Jacobson, Dilip K. Tosh, John A. Auchampach, David I. Lieberman, Naili Liu
Publikováno v:
Journal of Medicinal Chemistry. 62:1502-1522
(N)-Methanocarba ([3.1.0]bicyclohexyl) adenosines and corresponding ribosides were synthesized to identify novel A1 adenosine receptor (A1AR) agonists for CNS or peripheral applications. Human and mouse AR binding was determined to assess the constra
Autor:
Jason Ernst, Charles E. Breeze, Kelli L. Vaughan, Joseph A. Zoller, Julie A. Mattison, Anna J. Jasinska, Steve Horvath, Amin Haghani, Ken Raj
Publikováno v:
GeroScience
GeroScience, vol 43, iss 5
GeroScience, vol 43, iss 5
Methylation levels at specific CpG positions in the genome have been used to develop accurate estimators of chronological age in humans, mice, and other species. Although epigenetic clocks are generally species-specific, the principles underpinning t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20a00e1063afcd1fe0bd5b551fb6e60
https://doi.org/10.1101/2020.09.21.307108
https://doi.org/10.1101/2020.09.21.307108
Autor:
Douglas L. Rosene, Julie A. Mattison, R L Woltjer, Henryk F. Urbanski, Donald K. Ingram, G A Stonebarger, Kelli L. Vaughan, Steven G. Kohama, P L Schultz, S M Calderazzo, J A Siedeman
Publikováno v:
GeroScience
As human lifespan increases and the population ages, diseases of aging such as Alzheimer’s disease (AD) are a major cause for concern. Although calorie restriction (CR) as an intervention has been shown to increase healthspan in many species, few s
Autor:
Julie A. Mattison, Kelli L. Vaughan, Ricki J. Colman, Camila Vieira Ligo Teixeira, Eleonora Duregon, Josephine M. Egan, Andrew Deighan, Dushani L. Palliyaguru, Luanne L. Peters, Rafael de Cabo, Simonetta Camandola, Gary A. Churchill, David B. Allison, Eric J. Shiroma, Rozalyn M. Anderson, Ron Korstanje, Luigi Ferrucci, Michel Bernier, John K. Nam, Eleanor M. Simonsick, Keisuke Ejima, Chee W. Chia, Lenore J. Launer, Nathan L. Price, Stephanie L. Dickinson
Publikováno v:
Cell Metab
Summary Aging leads to profound changes in glucose homeostasis, weight, and adiposity, which are considered good predictors of health and survival in humans. Direct evidence that these age-associated metabolic alterations are recapitulated in animal
Autor:
Robert Peaden, Kelli L. Vaughan, Tamzin A. Kaiser, Rafael de Cabo, R. Michael Anson, Julie A. Mattison
Publikováno v:
The Journals of Gerontology: Series A. 73:48-53
For a century, we have known that caloric restriction influences aging in many species. However, only recently it was firmly established that the effect is not entirely dependent on the calories provided. Instead, rodent and nonhuman primate models h
Autor:
Jishnu Das, Elisabeth M Ricci-Blair, Ana Vujic, Kelli L. Vaughan, Annie C Wang, Niranjana Natarajan, Ricki J. Colman, Spencer Kiehm, Richard T. Lee, Krystal K Phu, Anthony Y Zhu, Julie A. Mattison
Publikováno v:
JCI Insight. 4
Calorie restriction (CR) improved health span in 2 longitudinal studies in nonhuman primates (NHPs), yet only the University of Wisconsin (UW) study demonstrated an increase in survival in CR monkeys relative to controls; the National Institute on Ag