Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Kelli L. Goss"'
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background The treatment of Ewing sarcoma, an aggressive bone and soft tissue sarcoma, is associated with suboptimal outcomes and significant side-effects. Consequently, there is an urgent need to identify novel therapies that will improve o
Externí odkaz:
https://doaj.org/article/c6df154561694243885a70d3e046906f
Supplementary Figure 7 shows cell cycle analysis for CDK1-AF cells and immunoblotting for P-Lamin A/C.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aca5ddb47acc5991a1188e84f234aca
https://doi.org/10.1158/1541-7786.22512577.v1
https://doi.org/10.1158/1541-7786.22512577.v1
Inhibition of ribonucleotide reductase (RNR), the rate-limiting enzyme in the synthesis of deoxyribonucleotides, causes DNA replication stress and activates the ataxia telangiectasia and rad3-related protein (ATR)-checkpoint kinase 1 (CHK1) pathway.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47322a624d99d9ef29c92463275c176a
https://doi.org/10.1158/1541-7786.c.6540280.v1
https://doi.org/10.1158/1541-7786.c.6540280.v1
Supplementary Figure 8 shows the effect of gemcitabine on the phosphorylation of 4E-BP1 in non-Ewing sarcoma cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b6442023724d1d12af75561abe880f
https://doi.org/10.1158/1535-7163.22504360
https://doi.org/10.1158/1535-7163.22504360
Supplementary Figure 6 shows the effect of RRM2 knockdown in Ewing sarcoma cells, as well as RT-qPCR data for cells treated with AZD1775 and LY2603618.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a0c690344af9a0d67bb6cd1b68ec51
https://doi.org/10.1158/1541-7786.22512580.v1
https://doi.org/10.1158/1541-7786.22512580.v1
Supplementary Figure 2 shows detection of protein synthesis using puromycin labeling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443524b26ac4c3d552b7c00460f94829
https://doi.org/10.1158/1535-7163.22504381.v1
https://doi.org/10.1158/1535-7163.22504381.v1
Supplementary Figure 6 shows the effect of drug treatments on mice weights in the xenograft experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ed9e0767183a4cee3938c6b56698ee
https://doi.org/10.1158/1535-7163.22504366.v1
https://doi.org/10.1158/1535-7163.22504366.v1
Supplementary Figure 5 shows a Loewe matrix plot for VX-970 and AZD1775.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1731abd9f86f8cafe39c8c50e668254e
https://doi.org/10.1158/1541-7786.22512583
https://doi.org/10.1158/1541-7786.22512583
Supplementary Figure 3 shows the effects of a CHK1 inhibitor on the shRRM1 and shRRM2 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff0bc928d3a40c3e6e51a14f09a2162
https://doi.org/10.1158/1541-7786.22512589.v1
https://doi.org/10.1158/1541-7786.22512589.v1
Supplementary Figure 4 shows the effect of LY2603618 and AZD1775 on cell cycle and the impact of AZD1775 and AZD6738 on cell growth.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::535625dfe34ad12206301cd3c5129661
https://doi.org/10.1158/1541-7786.22512586
https://doi.org/10.1158/1541-7786.22512586