Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kelli L, Jordan"'
Autor:
Nicholas C. Vierra, Matthew T. Dickerson, Kelli L. Jordan, Prasanna K. Dadi, Ketaki A. Kadare, Molly K. Altman, Sarah C. Milian, David A. Jacobson
Publikováno v:
Molecular Metabolism, Vol 9, Iss , Pp 84-97 (2018)
Objective: Single-cell RNA sequencing studies have revealed that the type-2 diabetes associated two-pore domain K+ (K2P) channel TALK-1 is abundantly expressed in somatostatin-secreting δ-cells. However, a physiological role for TALK-1 in δ-cells r
Externí odkaz:
https://doaj.org/article/1d9f371e00d5410b87f2af7f170d89cf
Autor:
Karolina E. Zaborska, Kelli L. Jordan, Ariel S. Thorson, Prasanna K. Dadi, Charles M. Schaub, Arya Y. Nakhe, Matthew T. Dickerson, Joshua C. Lynch, Adam J. Weiss, Jordyn R. Dobson, David A. Jacobson
Publikováno v:
Diabetes Obes Metab
AIM: To determine whether hyperpolarization-activated cyclic nucleotide-gated (HCN) channels impact glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) modulation of islet Ca(2+) handling and insulin secretion. METHODS: The impact of liraglutide (GLP-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48fdab110582ef02ffb7bb0f51d09922
https://europepmc.org/articles/PMC9843726/
https://europepmc.org/articles/PMC9843726/
Autor:
Kelli L. Jordan, Prasanna Dadi, Matthew Dickerson, David A. Jacobson, Sarah M. Graff, Karolina E. Zaborska
Publikováno v:
Diabetes. 70
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels control human β-cell insulin secretion. Here, we examined if HCN channels impact glucagon-like-peptide 1 (GLP-1) receptor modulation of islet Ca2+ handling. We found that Liraglutide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdd3276c00fca594e00c864394d21953
https://doi.org/10.2337/db21-227-lb
https://doi.org/10.2337/db21-227-lb
Autor:
David A. Jacobson, Kelli L. Jordan, Matthew T. Dickerson, Chloe E. Ibsen, Sarah M. Graff, Prasanna K. Dadi
Publikováno v:
Diabetes. 68
During Glucose-Stimulated Insulin Secretion (GSIS), β-cells exhibit oscillations in cytosolic Ca2+ ([Ca2+]c) and endoplasmic reticulum (ER) Ca2+ ([Ca2+]ER), which are regulated by the two-pore domain K+ channel, TALK-1. TALK-1 is the most abundant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aad3cc76163fa9ca9c180cd402b4efb3
https://doi.org/10.2337/db19-40-or
https://doi.org/10.2337/db19-40-or
Autor:
Matthew T. Dickerson, Ariel S. Thorson, Molly K. Altman, Gautami Amarnath, Nicholas C. Vierra, David A. Jacobson, Kelli L. Jordan, Kenneth R. Verlage, Prasanna K. Dadi
Pancreatic α-cells exhibit oscillations in cytosolic Ca2+(Ca2+c), which control pulsatile glucagon (GCG) secretion. However, the mechanisms that modulate α-cell Ca2+coscillations have not been elucidated. As β-cell Ca2+coscillations are regulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d53efd085db7cb0d80cb200c5f0727
https://europepmc.org/articles/PMC6482666/
https://europepmc.org/articles/PMC6482666/
Publikováno v:
Metabolism. 104:154069
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8af24d856b7aa076ac7e8dcc7473512
https://doi.org/10.1016/j.metabol.2019.12.015
https://doi.org/10.1016/j.metabol.2019.12.015
Autor:
Kelli L. Jordan, Sarah C. Milian, David A. Jacobson, Molly K. Altman, Avery M. Bogart, Prasanna K. Dadi, Matthew T. Dickerson
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Cytokines present during low-grade inflammation contribute to β-cell dysfunction and diabetes. Cytokine signaling disrupts β-cell glucose-stimulated Ca2+ influx (GSCI) and endoplasmic reticulum (ER) Ca2+ ([Ca2+]ER) handling, leading to diminished g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0855bcc1398021a73ab630a1c3ba55
https://doi.org/10.1038/s41598-018-19600-x
https://doi.org/10.1038/s41598-018-19600-x
Autor:
Matthew T, Dickerson, Avery M, Bogart, Molly K, Altman, Sarah C, Milian, Kelli L, Jordan, Prasanna K, Dadi, David A, Jacobson
Publikováno v:
Scientific Reports
Cytokines present during low-grade inflammation contribute to β-cell dysfunction and diabetes. Cytokine signaling disrupts β-cell glucose-stimulated Ca2+ influx (GSCI) and endoplasmic reticulum (ER) Ca2+ ([Ca2+]ER) handling, leading to diminished g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a4113e0b772f6906224e2e74eff9b82c
https://pubmed.ncbi.nlm.nih.gov/29348619
https://pubmed.ncbi.nlm.nih.gov/29348619
Autor:
Matthew T. Dickerson, Sarah C. Milian, Prasanna K. Dadi, Patrick Gilon, David A. Jacobson, Kelli L. Jordan, Nicholas C. Vierra
Ca2+ handling by the endoplasmic reticulum (ER) serves critical roles controlling pancreatic β-cell function and becomes perturbed during the pathogenesis of diabetes. ER Ca2+ homeostasis is determined by ion movements across the ER membrane, includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed18d8a1deed89b3d288476d7a1246b4
https://europepmc.org/articles/PMC5672804/
https://europepmc.org/articles/PMC5672804/