Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kelli D. Plunket"'
Autor:
Deborah A. Winegar, Peter J. Brown, William O. Wilkison, Michael C. Lewis, Ronda J. Ott, W.Q. Tong, H. Roger Brown, Jurgen M. Lehmann, Steven A. Kliewer, Kelli D. Plunket, James M. Way, Noni L. Bodkin, Barbara C. Hansen
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 10, Pp 1543-1551 (2001)
Fenofibrate is a member of the fibrate class of hypolipidemic agents used clinically to treat hypertriglyceridemia and mixed hyperlipidemia. The fibrates were developed primarily on the basis of their cholesterol and triglyceride lowering in rodents.
Externí odkaz:
https://doaj.org/article/e18df182ec9643e695a1b3b91bee8a1d
Autor:
Roderick G. Davis, Emily A. Hull-Ryde, Jon L. Collins, Jennifer L. Shenk, James M. Lenhard, Thomas G. Consler, Julie B. Stimmel, Timothy M. Willson, Lisa M. Leesnitzer, Steven G. Blanchard, Jeff E. Cobb, Christina Therapontos, Lisa G. Patel, Derek J. Parks, Kelli D. Plunket, Randy K. Bledsoe
Publikováno v:
Biochemistry. 41:6640-6650
In the course of a high throughput screen to search for ligands of peroxisome proliferator activated receptor-gamma (PPARgamma), we identified GW9662 using a competition binding assay against the human ligand binding domain. GW9662 had nanomolar IC(5
Autor:
Daniel D. Sternbach, Timothy M. Willson, Peter Brown, Kevin G. Liu, William R. Oliver, Kelli D. Plunket, Ludwig William Stuart, Millard H. Lambert, Ronda J. Ott, Lisa M. Leesnitzer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2959-2962
We have developed a general solid-phase synthesis for identification of PPAR ligands. Synthesis of a 480-member library led to the identification of a potent PPAR gamma/delta dual agonist 23. Compound 23 showed good plasma exposure in rats and demons
Autor:
Ronda J. Ott, James M. Way, Deborah A. Winegar, Barbara C. Hansen, Noni L. Bodkin, Jürgen M. Lehmann, W.Q. Tong, Steven A. Kliewer, H. Roger Brown, Peter Brown, William O. Wilkison, Michael C. Lewis, Kelli D. Plunket
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 10, Pp 1543-1551 (2001)
Fenofibrate is a member of the fibrate class of hypolipidemic agents used clinically to treat hypertriglyceridemia and mixed hyperlipidemia. The fibrates were developed primarily on the basis of their cholesterol and triglyceride lowering in rodents.
Autor:
Noelle Potier, Dino Moras, Steven G. Blanchard, Johan Auwerx, Pierre Bac, Jean-Paul Renaud, Denis Zeyer, Frédéric Picard, Laurent Dubuquoy, Lisa M. Leesnitzer, Pierre Desreumaux, Kelli D. Plunket, Marie-France Champy, Laurent Gelman, Joseph Vamecq, Stéphane Rocchi
Publikováno v:
Molecular Cell
Molecular Cell, Elsevier, 2001, 8 (4), pp.737-747. ⟨10.1016/s1097-2765(01)00353-7⟩
Molecular Cell, Elsevier, 2001, 8 (4), pp.737-747. ⟨10.1016/s1097-2765(01)00353-7⟩
FMOC-L-Leucine (F-L-Leu) is a chemically distinct PPARgamma ligand. Two molecules of F-L-Leu bind to the ligand binding domain of a single PPARgamma molecule, making its mode of receptor interaction distinct from that of other nuclear receptor ligand
Autor:
Andrea H. Ayscue, Daniel D. Sternbach, Millard H. Lambert, Jennifer S. Smith, Timothy M. Willson, Brad R. Henke, Kelli D. Plunket, Kevin G. Liu, Lisa M. Leesnitzer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2385-2388
A series of oxadiazole-substituted α-isopropoxy phenylpropanoic acids with dual agonist activity on PPARα and PPARγ is described. Several of these compounds also showed partial agonist activity on PPARδ. Resolution of one analogue showed that PPA
Autor:
Derek J. Parks, Michael C. Lewis, Curt D. Haffner, Linda B. Moore, Stacey A. Jones, Adam M. Fivush, Timothy M. Willson, Kelli D. Plunket, Katrina L. Creech, Joan G. Wilson, Patrick R. Maloney, Gyan Chandra
Publikováno v:
Journal of Medicinal Chemistry. 43:2971-2974
Autor:
James M. Lenhard, Evan G. Boswell, Derek J. Parks, Jeffery Oplinger, Debra H. Lake, Jeff E. Cobb, Emily A. Hull-Ryde, Jon L. Collins, Steven G. Blanchard, Milana Dezube, Kathleen K. Brown, Joel P. Cooper, William R. Oliver, Mila Pentti, Brad R. Henke, Paul S. Charifson, Kelli D. Plunket, Wei-Qin Tong
Publikováno v:
Journal of Medicinal Chemistry. 41:5055-5069
3-¿4-[2-(Benzoxazol-2-ylmethylamino)ethoxy]phenyl¿-(2S)-((2- benzoylph enyl)amino)propionic acid (1) and (2S)-((2-benzoylphenyl)amino)-3-¿4-[2-(5-methyl-2-phenyloxazol-4-y l)e thoxy]phenyl¿propionic acid (2) are peroxisome proliferator-activated
Autor:
Andrea M. Sefler, Kelli D. Plunket, Nicholas C. O. Tomkinson, Timothy M. Willson, Steven G. Blanchard, Derek J. Parks
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2491-2496
A library of thiazolidinedione-fatty acid hybrid molecules was designed to probe the relationship between natural and synthetic PPAR ligands. Solid-phase synthesis of the library led to the identification of several high affinity PPARγ ligands.
Autor:
Steven A. Kliewer, James E. Weiel, Mark A. Paulik, Kelli D. Plunket, Jürgen M. Lehmann, James M. Lenhard
Publikováno v:
Biochemical Pharmacology. 54:801-808
Troglitazone and metformin are antidiabetic agents that belong to the thiazolidinedione and biguanide classes of drugs, respectively. To evaluate how these drugs influence fuel utilization, we compared their effects on several pathways regulating car