Výsledky vyhledávání - "Kelli Craven"

Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer Rifampicin on the Pharmacokinetic Parameters of Fostamatinib: Results from In Vitro and Phase I Clinical Studies

Autor: Paul D. Martin, Clive Brealey, Tim Mant, David J. Sweeny, Kelli Craven, Elliott B. Grossbard, Stuart Oliver, David Millson, Muhammad Baluom, David Lau, Michael Gillen

Publikováno v: Drugs in R&D

Background Fostamatinib (R788) is a spleen tyrosine kinase (SYK) inhibitor. The active metabolite of fostamatinib, R406, is primarily metabolized by CYP3A4. Objectives The aim of this study was to characterize hepatic microsomal metabolism of R406 an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500247c9fefb954306521b3088336334
https://pubmed.ncbi.nlm.nih.gov/26739683

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání