Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kelley R. Hurst-Hess"'
Publikováno v:
Tuberculosis. 138:102295
Mycobacterium abscessus is highly resistant to spectinomycin (SPC) thereby making it unavailable for therapeutic use. Sublethal exposure to SPC strongly induces whiB7 and its regulon, and a ΔMab_whiB7 strain is SPC sensitive suggesting that the dete
Publikováno v:
Virology
The coronavirus nucleocapsid (N) protein comprises two RNA-binding domains connected by a central spacer, which contains a serine- and arginine-rich (SR) region. The SR region engages the largest subunit of the viral replicase-transcriptase, nonstruc
Publikováno v:
Antimicrob Agents Chemother
Mycobacterium abscessus has emerged as a successful pathogen owing to its intrinsic drug resistance. Macrolide and lincosamide antibiotics share overlapping binding sites within the ribosome and common resistance pathways. Nevertheless, while M. absc
Publikováno v:
Molecular Cell. 82:3166-3177.e5
Rifampicin (RIF), the frontline drug against M. tuberculosis, is completely ineffective against M. abscessus, partially due to the presence of an ADP-ribosyltransferase (Arr) that inactivates RIF. Using RNA-seq, we show that exposure of M. abscessus
Rifampicin (RIF) constitutes the frontline therapy against M. tuberculosis as well as most slow-growing non-tuberculous mycobacteria (NTM). However, RIF is completely ineffective against M. abscessus despite the absence of mutations in the rifampicin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fef8b38fda54ce4753a69dc6f931234a
https://doi.org/10.1101/2021.05.10.443476
https://doi.org/10.1101/2021.05.10.443476
Publikováno v:
SSRN Electronic Journal.
Bacterial RNA polymerase is a target of the potent and broad-spectrum rifamycin group of antibiotics. Mutations within rpoB and inactivation by a diverse group of enzymes constitute the most widespread mechanisms of resistance. Rifampicin (RIF) const
Autor:
Pallavi Ghosh, Paulami Rudra, Kelley R. Hurst-Hess, Andrea Partida-Miranda, Katherine L. Cotten
Publikováno v:
Proc Natl Acad Sci U S A
Antibiotic resistance in bacteria is typically conferred by proteins that function as efflux pumps or enzymes that modify either the drug or the antibiotic target. Here we report an unusual mechanism of resistance to macrolide-lincosamide antibiotics
Autor:
Yong Yang, Paulami Rudra, Erica Lasek-Nesselquist, Pallavi Ghosh, Rajesh Kumar Biswas, Kelley R. Hurst-Hess
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
mBio, Vol 10, Iss 3, p e00273-19 (2019)
mBio
mBio, Vol 10, Iss 3, p e00273-19 (2019)
mBio
All mycobacteria encode a group II sigma factor, σB, closely related to the group I principal housekeeping sigma factor, σA. Group II sigma factors are widely believed to play specialized roles in the general stress response and stationary-phase tr
Publikováno v:
Journal of Virology
The coronavirus membrane (M) protein is the central actor in virion morphogenesis. M organizes the components of the viral membrane, and interactions of M with itself and with the nucleocapsid (N) protein drive virus assembly and budding. In order to
Publikováno v:
Antimicrobial Agents and Chemotherapy. 62
Tetracyclines have been one of the most successful classes of antibiotics. However, its extensive use has led to the emergence of widespread drug resistance, resulting in discontinuation of use against several bacterial infections. Prominent resistan