Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Kelley L. Colvin"'
Autor:
Kelley L. Colvin, Robert J. Elliott, Desiree M. Goodman, Julie Harral, Edward G. Barrett, Michael E. Yeager
Publikováno v:
FASEB BioAdvances, Vol 5, Iss 12, Pp 528-540 (2023)
Abstract Objectives We sought to investigate whether the Dp16 mouse model of Down syndrome (DS) is more susceptible to severe and lethal respiratory tract infection by Streptococcus pneumoniae. Study Design We infected controls and Dp16 mice with Str
Externí odkaz:
https://doaj.org/article/123a846c4e7745399ebb91fbc07f2727
Autor:
Kelley L. Colvin, Kathleen Nguyen, Katie L. Boncella, Desiree M. Goodman, Robert J. Elliott, Julie W. Harral, Jill Bilodeaux, Bradford J. Smith, Michael E. Yeager
Publikováno v:
Genes, Vol 14, Iss 9, p 1819 (2023)
(1) Background: We sought to investigate the baseline lung and heart biology of the Dp16 mouse model of Down syndrome (DS) as a prelude to the investigation of recurrent respiratory tract infection. (2) Methods: In controls vs. Dp16 mice, we compared
Externí odkaz:
https://doaj.org/article/e1a13ad713c14e0f8caf7d0086517b75
Autor:
Katherine A. Waugh, Paula Araya, Ahwan Pandey, Kimberly R. Jordan, Keith P. Smith, Ross E. Granrath, Santosh Khanal, Eric T. Butcher, Belinda Enriquez Estrada, Angela L. Rachubinski, Jennifer A. McWilliams, Ross Minter, Tiana Dimasi, Kelley L. Colvin, Dmitry Baturin, Andrew T. Pham, Matthew D. Galbraith, Kyle W. Bartsch, Michael E. Yeager, Christopher C. Porter, Kelly D. Sullivan, Elena W. Hsieh, Joaquin M. Espinosa
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 1893-1908.e4 (2019)
Summary: People with Down syndrome (DS; trisomy 21) display a different disease spectrum relative to the general population, including lower rates of solid malignancies and higher incidence of neurological and autoimmune conditions. However, the mech
Externí odkaz:
https://doaj.org/article/5e8ba4aab3a0402a9359cd3e3d5c2332
Autor:
Kelley L. Colvin, Michael E. Yeager
Publikováno v:
European Respiratory Review, Vol 26, Iss 143 (2017)
Down syndrome is the most common chromosomal abnormality among live-born infants. Through full or partial trisomy of chromosome 21, Down syndrome is associated with cognitive impairment, congenital malformations (particularly cardiovascular) and dysm
Externí odkaz:
https://doaj.org/article/7a0c1bdf02af4d178869619fc974d209
Autor:
Michal Schäfer, Michael E. Yeager, Benjamin S. Frank, Uyen Truong, Kathleen Nguyen, Katie L Boncella, Kathleen Miller-Reed, Gareth J. Morgan, Kelley L. Colvin, D. Dunbar Ivy
Publikováno v:
Am J Physiol Heart Circ Physiol
Disturbed balance between matrix metalloproteinases (MMPs) and their respective tissue inhibitors (TIMPs) is a well-recognized pathophysiological component of pulmonary arterial hypertension (PAH). Both classes of proteinases have been associated wit
Autor:
Kelley L. Colvin, Kyle Bartsch, Ross Minter, Belinda Enriquez Estrada, Katherine A. Waugh, Tiana Dimasi, Angela L. Rachubinski, Ross E Granrath, Michael E. Yeager, Keith P Smith, Kelly D. Sullivan, Paula Araya, Jennifer A. McWilliams, Dmitry Baturin, Joaquín M. Espinosa, Matthew D. Galbraith, Kimberly R. Jordan, Santosh Khanal, Andrew T. Pham, Christopher C. Porter, Eric T. Butcher, Elena W Y Hsieh, Ahwan Pandey
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 1893-1908.e4 (2019)
Summary: People with Down syndrome (DS; trisomy 21) display a different disease spectrum relative to the general population, including lower rates of solid malignancies and higher incidence of neurological and autoimmune conditions. However, the mech
Publikováno v:
Paediatric Respiratory Reviews. 16:225-231
Pediatric pulmonary arterial hypertension (PAH) is an uncommon disease that can occur in neonates, infants, and children, and is associated with high morbidity and mortality. Despite advances in treatment strategies over the last two decades, the und
Autor:
Michael E. Yeager, Deviyani M. Rao, Anne-Laure Perraud, Carsten Schmitz, Kelley L. Colvin, Fabienne Gally
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease. 1864(1)
Trisomy 21 (Down Syndrome, DS) is the most common chromosomal anomaly. Although DS is mostly perceived as affecting cognitive abilities and cardiac health, individuals with DS also exhibit dysregulated immune functions. Levels of pro-inflammatory cyt
Publikováno v:
PROTEOMICS - Clinical Applications. 6:257-267
Purpose: The prognosis for children with IPAH unresponsive to therapy is poor. We investigated the plasma proteome for a molecular basis of good versus poor outcome to long-term vasodilator therapy. Experimental design: Plasma was collected at baseli
Autor:
Kurt R. Stenmark, D. Dunbar Ivy, Michael E. Yeager, Cecilia M. Nguyen, Monica B. Reddy, Kelley L. Colvin
Publikováno v:
Pulmonary Circulation
Pulmonary hypertension remains an important cause of morbidity and mortality. Although there is currently no cure, descriptions of defective intracellular trafficking and protein misfolding in vascular cell models of pulmonary hypertension have been