Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Kelley Harris"'
Publikováno v:
eLife, Vol 12 (2024)
Maintaining germline genome integrity is essential and enormously complex. Although many proteins are involved in DNA replication, proofreading, and repair, mutator alleles have largely eluded detection in mammals. DNA replication and repair proteins
Externí odkaz:
https://doaj.org/article/00370c14fb404512aa49c1e42bce4479
Autor:
Daniel Promislow, Rozalyn M. Anderson, Marten Scheffer, Bernard Crespi, James DeGregori, Kelley Harris, Barbara Natterson Horowitz, Morgan E. Levine, Maria A. Riolo, David S. Schneider, Sabrina L. Spencer, Dario Riccardo Valenzano, Michael E. Hochberg
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104199- (2022)
Summary: Aging research is unparalleled in the breadth of disciplines it encompasses, from evolutionary studies examining the forces that shape aging to molecular studies uncovering the underlying mechanisms of age-related functional decline. Despite
Externí odkaz:
https://doaj.org/article/b80faeaf247e401282c9a01788bd15ad
Autor:
Lucie A Bergeron, Søren Besenbacher, Tychele Turner, Cyril J Versoza, Richard J Wang, Alivia Lee Price, Ellie Armstrong, Meritxell Riera, Jedidiah Carlson, Hwei-yen Chen, Matthew W Hahn, Kelley Harris, April Snøfrid Kleppe, Elora H López-Nandam, Priya Moorjani, Susanne P Pfeifer, George P Tiley, Anne D Yoder, Guojie Zhang, Mikkel H Schierup
Publikováno v:
eLife, Vol 11 (2022)
In the past decade, several studies have estimated the human per-generation germline mutation rate using large pedigrees. More recently, estimates for various nonhuman species have been published. However, methodological differences among studies in
Externí odkaz:
https://doaj.org/article/d731add1c7b74d45809114cfd96ce456
Publikováno v:
eLife, Vol 10 (2021)
Although studies of Saccharomyces cerevisiae have provided many insights into mutagenesis and DNA repair, most of this work has focused on a few laboratory strains. Much less is known about the phenotypic effects of natural variation within S. cerevi
Externí odkaz:
https://doaj.org/article/c7105fd1b6ec43f595ed2466e85f39a3
Autor:
Jedidiah Carlson, Kelley Harris
Publikováno v:
PLoS Biology, Vol 18, Iss 9, p e3000860 (2020)
Engagement with scientific manuscripts is frequently facilitated by Twitter and other social media platforms. As such, the demographics of a paper's social media audience provide a wealth of information about how scholarly research is transmitted, co
Externí odkaz:
https://doaj.org/article/c5eafe3a2bd34b749bf6622fb982fff8
Autor:
Kelley Harris, Rasmus Nielsen
Publikováno v:
BMC Biology, Vol 15, Iss 1, Pp 1-3 (2017)
Abstract Genomic evidence has demonstrated that humans and Neanderthals interbred. Today, the genomes of most individuals outside Africa contain 2–3% Neanderthal DNA. However, it is still hotly debated why the Neanderthals went extinct and if human
Externí odkaz:
https://doaj.org/article/4d1697771b8b442aae8a5327e2822304
Autor:
Kelley Harris
Publikováno v:
eLife, Vol 7 (2018)
Just 5% of the human genome is subject to neutral evolution, but this process remains central to understanding the history of human migration across the Earth.
Externí odkaz:
https://doaj.org/article/93814816196947efa8ac763f4337acea
Autor:
Kelley Harris, Jonathan K Pritchard
Publikováno v:
eLife, Vol 6 (2017)
DNA is a remarkably precise medium for copying and storing biological information. This high fidelity results from the action of hundreds of genes involved in replication, proofreading, and damage repair. Evolutionary theory suggests that in such a s
Externí odkaz:
https://doaj.org/article/899c237035854f94a1f8f16e9c5f6a24
Autor:
Kelley Harris, Rasmus Nielsen
Publikováno v:
PLoS Genetics, Vol 9, Iss 6, p e1003521 (2013)
There has been much recent excitement about the use of genetics to elucidate ancestral history and demography. Whole genome data from humans and other species are revealing complex stories of divergence and admixture that were left undiscovered by pr
Externí odkaz:
https://doaj.org/article/9ba781f415634763bc47732c71833cc7
Autor:
Thomas A. Sasani, David G. Ashbrook, Annabel C. Beichman, Lu Lu, Abraham A. Palmer, Robert W. Williams, Jonathan K. Pritchard, Kelley Harris
Publikováno v:
Nature
Summary ParagraphAlthough germline mutation rates and spectra can vary within and between species, genetic modifiers of these traits have long eluded detection. In this study, we searched for loci that influence germline mutagenesis using a uniquely