N ^α -acetyl-L-ornithine deacetylase from Escherichia coli and a ninhydrin-based assay to enable inhibitor identification.

Autor: Kelley EH; Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL, United States., Osipiuk J; Structural Biology Center, Argonne National Laboratory, X-ray Science Division, Lemont, IL, United States.; eBERlight, Argonne National Laboratory, X-ray Science Division, Lemont, IL, United States.; Center for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, United States., Korbas M; Canadian Light Source, Saskatoon, SK, Canada., Endres M; Center for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, United States., Bland A; Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL, United States., Ehrman V; Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL, United States., Joachimiak A; Structural Biology Center, Argonne National Laboratory, X-ray Science Division, Lemont, IL, United States.; Center for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, United States.; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, United States., Olsen KW; Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL, United States., Becker DP; Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL, United States.

Publikováno v: Frontiers in chemistry [Front Chem] 2024 Jul 11; Vol. 12, pp. 1415644. Date of Electronic Publication: 2024 Jul 11 (Print Publication: 2024).

Biochemical and Structural Analysis of the Bacterial Enzyme Succinyl-Diaminopimelate Desuccinylase (DapE) from Acinetobacter baumannii .

Autor: Kelley EH; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, Illinois 60660, United States., Minasov G; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States.; Center for Structural Biology of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States., Konczak K; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, Illinois 60660, United States., Shuvalova L; Department of Pharmacology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States., Brunzelle JS; Northwestern Synchrotron Research Center, Life Sciences Collaborative Access Team, Northwestern University, Argonne, Illinois 60439, United States., Shukla S; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States.; Center for Structural Biology of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States., Beulke M; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, Illinois 60660, United States., Thabthimthong T; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, Illinois 60660, United States., Olsen KW; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, Illinois 60660, United States., Inniss NL; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States.; Center for Structural Biology of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States., Satchell KJF; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States.; Center for Structural Biology of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States., Becker DP; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, Illinois 60660, United States.

Publikováno v: ACS omega [ACS Omega] 2024 Jan 08; Vol. 9 (3), pp. 3905-3915. Date of Electronic Publication: 2024 Jan 08 (Print Publication: 2024).

Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors.

Autor: Taylor AM; Relay Therapeutics, Inc., 399 Binney St., Cambridge,, Massachusetts 02139, United States., Williams BR; Relay Therapeutics, Inc., 399 Binney St., Cambridge,, Massachusetts 02139, United States., Giordanetto F; D. E. Shaw Research, 120 W. 45th St., 39th Fl., New York, New York 10036, United States., Kelley EH; Relay Therapeutics, Inc., 399 Binney St., Cambridge,, Massachusetts 02139, United States., Lescarbeau A; Relay Therapeutics, Inc., 399 Binney St., Cambridge,, Massachusetts 02139, United States., Shortsleeves K; Relay Therapeutics, Inc., 399 Binney St., Cambridge,, Massachusetts 02139, United States., Tang Y; Relay Therapeutics, Inc., 399 Binney St., Cambridge,, Massachusetts 02139, United States., Walters WP; Relay Therapeutics, Inc., 399 Binney St., Cambridge,, Massachusetts 02139, United States., Arrazate A; Genentech, Inc., 1 DNA Way Mailstop 258A, South San Francisco, California 94080-4990, United States., Bowman C; Genentech, Inc., 1 DNA Way Mailstop 258A, South San Francisco, California 94080-4990, United States., Brophy E; Relay Therapeutics, Inc., 399 Binney St., Cambridge,, Massachusetts 02139, United States., Chan EW; Genentech, Inc., 1 DNA Way Mailstop 258A, South San Francisco, California 94080-4990, United States., Deshmukh G; Genentech, Inc., 1 DNA Way Mailstop 258A, South San Francisco, California 94080-4990, United States., Greisman JB; D. E. Shaw Research, 120 W. 45th St., 39th Fl., New York, New York 10036, United States., Hunsaker TL; Genentech, Inc., 1 DNA Way Mailstop 258A, South San Francisco, California 94080-4990, United States., Kipp DR; Relay Therapeutics, Inc., 399 Binney St., Cambridge,, Massachusetts 02139, United States., Saenz Lopez-Larrocha P; Genentech, Inc., 1 DNA Way Mailstop 258A, South San Francisco, California 94080-4990, United States., Maddalo D; Genentech, Inc., 1 DNA Way Mailstop 258A, South San Francisco, California 94080-4990, United States., Martin IJ; Relay Therapeutics, Inc., 399 Binney St., Cambridge,, Massachusetts 02139, United States., Maragakis P; D. E. Shaw Research, 120 W. 45th St., 39th Fl., New York, New York 10036, United States., Merchant M; Genentech, Inc., 1 DNA Way Mailstop 258A, South San Francisco, California 94080-4990, United States., Murcko M; Relay Therapeutics, Inc., 399 Binney St., Cambridge,, Massachusetts 02139, United States., Nisonoff H; D. E. Shaw Research, 120 W. 45th St., 39th Fl., New York, New York 10036, United States., Nguyen V; Relay Therapeutics, Inc., 399 Binney St., Cambridge,, Massachusetts 02139, United States., Nguyen V; Relay Therapeutics, Inc., 399 Binney St., Cambridge,, Massachusetts 02139, United States., Orozco O; Relay Therapeutics, Inc., 399 Binney St., Cambridge,, Massachusetts 02139, United States., Owen C; Relay Therapeutics, Inc., 399 Binney St., Cambridge,, Massachusetts 02139, United States., Pierce L; Relay Therapeutics, Inc., 399 Binney St., Cambridge,, Massachusetts 02139, United States., Schmidt M; Relay Therapeutics, Inc., 399 Binney St., Cambridge,, Massachusetts 02139, United States., Shaw DE; D. E. Shaw Research, 120 W. 45th St., 39th Fl., New York, New York 10036, United States.; Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168th St., New York, New York 10032, United States., Smith S; Relay Therapeutics, Inc., 399 Binney St., Cambridge,, Massachusetts 02139, United States., Therrien E; Schrödinger, Inc., 1540 Broadway, 24th Floor, New York, New York 10036, United States., Tran JC; Genentech, Inc., 1 DNA Way Mailstop 258A, South San Francisco, California 94080-4990, United States., Watters J; Relay Therapeutics, Inc., 399 Binney St., Cambridge,, Massachusetts 02139, United States., Waters NJ; Relay Therapeutics, Inc., 399 Binney St., Cambridge,, Massachusetts 02139, United States., Wilbur J; Relay Therapeutics, Inc., 399 Binney St., Cambridge,, Massachusetts 02139, United States., Willmore L; D. E. Shaw Research, 120 W. 45th St., 39th Fl., New York, New York 10036, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Oct 12; Vol. 66 (19), pp. 13384-13399. Date of Electronic Publication: 2023 Sep 29.

Tetrazole-based inhibitors of the bacterial enzyme N-succinyl-l,l-2,6-diaminopimelic acid desuccinylase as potential antibiotics.

Autor: DiPuma T Jr; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, IL 60660, USA., Thabthimthong T; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, IL 60660, USA., Kelley EH; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, IL 60660, USA., Konczak K; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, IL 60660, USA., Beulke M; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, IL 60660, USA., Herbert C; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, IL 60660, USA., S Habeeb Mohammad T; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, IL 60660, USA., Starus A; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, IL 60660, USA., Nocek B; Midwest Center for Structural Genomics and Structural Biology Center, Biosciences Division, Argonne National Laboratory, Argonne, IL 60439, USA., Olsen KW; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, IL 60660, USA., Holz RC; Department of Chemistry, Colorado School of Mines, 1500 Illinois St., Golden, CO 80401, USA. Electronic address: rholz@mines.edu., Becker DP; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, IL 60660, USA. Electronic address: dbecke3@luc.edu.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Mar 01; Vol. 83, pp. 129177. Date of Electronic Publication: 2023 Feb 09.

Synthesis of the ABC framework of tamulamides A and B.

Autor: Kelley EH; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139, United States., Jamison TF; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139, United States. Electronic address: tfj@mit.edu.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2018 Oct 15; Vol. 26 (19), pp. 5327-5335. Date of Electronic Publication: 2018 Apr 22.