Abstract 4309: Early apoptotic measurements of patient-derived organoids predict patient response to therapy

Autor: Kelley E. McQueeney, Patrick Bhola, Sarah J. Hill, Anthony Letai

Publikováno v: Cancer Research. 83:4309-4309

The use of imperfect models and ex vivo culture systems to try to predict patient drug response represents an enormous bottle neck in cancer treatment. Nonetheless, determining how effective an approved drug will be for an individual cancer patient,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f671a143c38b12eb087e5b0823266c9
https://doi.org/10.1158/1538-7445.am2023-4309

Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics

Autor: David T. Scadden, Kristopher A. Sarosiek, Isaac S. Harris, Joan S. Brugge, Vinícius Guimarães Ferreira, Danielle S. Potter, Veerle W. Daniels, Salma Parvin, Geoffrey Fell, Jennifer E. Endress, Patrick Bhola, Jason J. Zoeller, Rajat M. Gupta, Johan Spetz, Nick van Gastel, Emanuel Carrilho, Kelley E. McQueeney, Anthony Letai, Binyam Yilma

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Sci Signal

Cancer cells have differential metabolic dependencies compared to their non-malignant counterparts. However, few metabolism-targeting compounds have been successful in clinical trials. Here, we investigated the metabolic vulnerabilities of triple-neg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89553705ba3fc5934a2d914c7b0c87f3

High-throughput dynamic BH3 profiling may quickly and accurately predict effective therapies in solid tumors

Autor: Kimmie Ng, Alaba Sotayo, Patrick Bhola, Elizaveta Lavrova, Kelley E. McQueeney, Otari Chipashvili, Ewa Sicinska, Timothy Hagan, Jennifer L. Guerriero, Eman Ahmed, Andrew J. Aguirre, Jeremy Ryan, David Cocozziello, Emily Su, Jean J. Zhao, Anthony Letai, James M. Cleary, Marissa S. Pioso, Jing Ni

Publikováno v: Sci Signal

Despite decades of effort, the sensitivity of patient tumors to individual drugs is often not predictable on the basis of molecular markers alone. Therefore, unbiased, high-throughput approaches to match patient tumors to effective drugs, without req

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea82a99c0f34d2e58b6c27bb9705799
https://pubmed.ncbi.nlm.nih.gov/32546544

Localization of a Trypanosome Peroxin to the Endoplasmic Reticulum

Autor: Kelley E. McQueeney, Terral Patel, Sarah Bauer, Meredith Morris

Publikováno v: The Journal of Eukaryotic Microbiology

Trypanosoma brucei is the causative agent of diseases that affect 30,000–50,000 people annually. Trypanosoma brucei harbors unique organelles named glycosomes that are essential to parasite survival, which requires growth under fluctuating environm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508acb023d7c6d4adc361e367ed66a5b
https://doi.org/10.1111/jeu.12343

Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor

Autor: Elizabeth R. Sharlow, James C. Burnett, John S. Lazo, Robert Cornelison, Nektarios Barabutis, John D. Catravas, Joseph M. Salamoun, Zhong Yin Zhang, Danielle C. Llaneza, Yunpeng Bai, Sophie L. Lewandowski, Paula Pekic, Peter Wipf, Kelley E. McQueeney, Charles N. Landen

Publikováno v: Oncotarget

// Kelley E. McQueeney 1 , Joseph M. Salamoun 2 , James C. Burnett 2 , Nektarios Barabutis 3 , Paula Pekic 1 , Sophie L. Lewandowski 1 , Danielle C. Llaneza 4 , Robert Cornelison 4 , Yunpeng Bai 5 , Zhong-Yin Zhang 5 , John D. Catravas 3 , Charles N.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254b9475a244ae7b76fa9120b32f376f
https://pubmed.ncbi.nlm.nih.gov/29492190