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Plasma proteomics analysis of patients with chronic spontaneous urticaria reveals significant associations with key disease characteristics but not with response to omalizumab treatment.

Autor: Ghazanfar MN; Department of Dermato-Venereology & Wound Healing Centre, Urticaria Center of Reference and Excellence (UCARE), Bispebjerg Hospital, Copenhagen, Denmark., Petrosius V; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Sørensen JA; Department of Dermato-Venereology & Wound Healing Centre, Urticaria Center of Reference and Excellence (UCARE), Bispebjerg Hospital, Copenhagen, Denmark., Zhang DG; Department of Dermato-Venereology & Wound Healing Centre, Urticaria Center of Reference and Excellence (UCARE), Bispebjerg Hospital, Copenhagen, Denmark., Ali Z; Department of Dermato-Venereology & Wound Healing Centre, Urticaria Center of Reference and Excellence (UCARE), Bispebjerg Hospital, Copenhagen, Denmark., Maurer M; Urticaria Center of Reference and Excellence (UCARE), Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany., Kocatürk E; Urticaria Center of Reference and Excellence (UCARE), Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.; Department of Dermatology, Koç University School of Medicine, Istanbul, Turkey., Nielsen VW; Department of Dermato-Venereology & Wound Healing Centre, Urticaria Center of Reference and Excellence (UCARE), Bispebjerg Hospital, Copenhagen, Denmark., Savickas S; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Keller UAD; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Schoof EM; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Thomsen SF; Department of Dermato-Venereology & Wound Healing Centre, Urticaria Center of Reference and Excellence (UCARE), Bispebjerg Hospital, Copenhagen, Denmark.; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

Publikováno v: Allergy [Allergy] 2024 Sep; Vol. 79 (9), pp. 2547-2550. Date of Electronic Publication: 2024 May 26.

Exploration of cell state heterogeneity using single-cell proteomics through sensitivity-tailored data-independent acquisition.

Autor: Petrosius V; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads 224 2800 Kgs, Lyngby, Denmark., Aragon-Fernandez P; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads 224 2800 Kgs, Lyngby, Denmark., Üresin N; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads 224 2800 Kgs, Lyngby, Denmark.; The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark., Kovacs G; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads 224 2800 Kgs, Lyngby, Denmark., Phlairaharn T; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads 224 2800 Kgs, Lyngby, Denmark.; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.; Department of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, 82152, Germany.; MaxPlanck Institute of Biochemistry, Martinsried, 82152, Germany., Furtwängler B; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads 224 2800 Kgs, Lyngby, Denmark.; The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark., Op De Beeck J; Thermo Fisher Scientific, Technologiepark-Zwijnaarde 82, B-9052, Gent, Belgium., Skovbakke SL; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads 224 2800 Kgs, Lyngby, Denmark., Goletz S; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads 224 2800 Kgs, Lyngby, Denmark., Thomsen SF; Department of Dermatology, Bispebjerg Hospital and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Keller UAD; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads 224 2800 Kgs, Lyngby, Denmark., Natarajan KN; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads 224 2800 Kgs, Lyngby, Denmark., Porse BT; The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark.; Dept of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Schoof EM; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads 224 2800 Kgs, Lyngby, Denmark. erws@dtu.dk.

Publikováno v: Nature communications [Nat Commun] 2023 Sep 22; Vol. 14 (1), pp. 5910. Date of Electronic Publication: 2023 Sep 22.

Neprilysin-dependent neuropeptide Y cleavage in the liver promotes fibrosis by blocking NPY-receptor 1.

Autor: Ortiz C; Department of Internal Medicine I, University Hospital Frankfurt, Frankfurt am Main, Germany., Klein S; Department of Internal Medicine I, University Hospital Frankfurt, Frankfurt am Main, Germany; Department of Internal Medicine B, University of Münster, Albert-Schweitzer Campus 1, 48149 Münster, Germany., Reul WH; Department of Internal Medicine I, University of Bonn, Bonn, Germany., Magdaleno F; Department of Internal Medicine I, University of Bonn, Bonn, Germany., Gröschl S; Department of Internal Medicine I, University of Bonn, Bonn, Germany., Dietrich P; Institute of Biochemistry, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany; Department of Internal Medicine 1, FAU Erlangen-Nuremberg and Universitätsklinikum Erlangen, Ulmenweg 18, 91054 Erlangen, Germany., Schierwagen R; Department of Internal Medicine I, University Hospital Frankfurt, Frankfurt am Main, Germany., Uschner FE; Department of Internal Medicine I, University Hospital Frankfurt, Frankfurt am Main, Germany., Torres S; Department of Internal Medicine I, University Hospital Frankfurt, Frankfurt am Main, Germany., Hieber C; Department of Internal Medicine I, University Hospital Frankfurt, Frankfurt am Main, Germany., Meier C; Department of Internal Medicine I, University Hospital Frankfurt, Frankfurt am Main, Germany., Kraus N; Department of Internal Medicine I, University Hospital Frankfurt, Frankfurt am Main, Germany., Tyc O; Department of Internal Medicine I, University Hospital Frankfurt, Frankfurt am Main, Germany., Brol M; Department of Internal Medicine I, University Hospital Frankfurt, Frankfurt am Main, Germany., Zeuzem S; Department of Internal Medicine I, University Hospital Frankfurt, Frankfurt am Main, Germany., Welsch C; Department of Internal Medicine I, University Hospital Frankfurt, Frankfurt am Main, Germany., Poglitsch M; Attoquant Diagnostics GmbH, Vienna, Austria., Hellerbrand C; Institute of Biochemistry, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany., Alfonso-Prieto M; Institute for Neuroscience and Medicine INM-9 and Institute for Advanced Simulations IAS-5, Forschungszentrum Jülich, Jülich, Germany; Cécile and Oskar Vogt Institute for Brain Research, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Mira F; Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark., Keller UAD; Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark., Tetzner A; Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland., Moore A; Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland., Walther T; Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland; Department of Pediatric Surgery, Centre for Fetal Medicine, Division of Women and Child Health, University of Leipzig, Leipzig, Germany; Department of Obstetrics, Centre for Fetal Medicine, Division of Women and Child Health, University of Leipzig, Leipzig, Germany., Trebicka J; Department of Internal Medicine I, University Hospital Frankfurt, Frankfurt am Main, Germany; Institute of Clinical Research, Odense University Hospital, University of Southern Denmark, Odense, Denmark; European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain; Institute for Bioengineering of Catalonia, Barcelona, Spain; Department of Internal Medicine B, University of Münster, Albert-Schweitzer Campus 1, 48149 Münster, Germany. Electronic address: jonel.trebicka@ukmuenster.de.

Publikováno v: Cell reports [Cell Rep] 2023 Feb 28; Vol. 42 (2), pp. 112059. Date of Electronic Publication: 2023 Jan 31.