DNA methylation landscape of the genes regulating D-serine and D-aspartate metabolism in post-mortem brain from controls and subjects with schizophrenia [*Keller S., Punzo D., Cuomo M co-primi autori]

Autor: Keller, Simona, PUNZO, DANIELA, Cuomo, Mariella, Affinito, Ornella, Coretti, Lorena, Sacchi, Silvia, Florio, Ermanno, Lembo, Francesca, Carella, Massimo, Copetti, Massimiliano, Cocozza, Sergio, Balu, Darrick T., Errico, Francesco, Usiello, Alessandro, Chiariotti, Lorenzo

The spatio-temporal regulation of genes involved in the synthesis and degradation of D-serine and D-aspartate such as serine racemase (SR), D-amino acid oxidase (DAO), G72 and D-aspartate oxidase (DDO), play pivotal roles in determining the correct l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::79b22e31a10cfc91a89ea20304b854b8
https://hdl.handle.net/11588/722907

Additional file 2: of Selective demethylation of two CpG sites causes postnatal activation of the Dao gene and consequent removal of d-serine within the mouse cerebellum

Autor: Cuomo, Mariella, Keller, Simona, Punzo, Daniela, Nuzzo, Tommaso, Affinito, Ornella, Coretti, Lorena, Carella, Massimo, Rosa, Valeria, Florio, Ermanno, Boscia, Francesca, Avvedimento, Vittorio, Cocozza, Sergio, Errico, Francesco, Usiello, Alessandro, Chiariotti, Lorenzo

Figure S2. Regression analysis associating the degree of methylation with mRNA expression levels of the Ddo gene. Regression analysis associating DNA methylation and mRNA expression of Ddo gene is shown in each analyzed brain area during development.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec5dccca3bd50874ffb655eda59f7a8

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Tracking the evolution of epialleles during neural differentiation and brain development: D- aspartate oxidase as a model gene

Autor: Florio, Ermanno, Keller, Simona, Coretti, Lorena, Affinito, Ornella, Scala, Giovanni, Errico, Francesco, Fico, Annalisa, Boscia, Francesca, Sisalli Maria, José, Reccia, Mafalda Giovanna, Monticell, A, Miele, Gennaro, Monticelli, Antonella, Scorziello, Antonella, Lembo, Francesca, Coluzzi-D´Amato, Luca, Minchiotti, Gabriella, Avvedimento, Vittorio Enrico, Usiello, Alessandro, Cocozza, Sergio, Chiariotti, Lorenzo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4853::86bea10618fe4e55294df0517de83f2a
https://trepo.tuni.fi/handle/10024/102471

Age-related changes in D-aspartate oxidase promoter methylation control extracellular D-aspartate levels and prevent precocious cell death during brain aging

Autor: Punzo, Daniela, Errico, Francesco, Cristino, Luigia, Sacchi, Silvia, Keller, Simona, Belardo, Carmela, Luongo, Livio, Nuzzo, Tommaso, Imperatore, Roberta, Florio, Ermanno, De Novellis, Vito, Affinito, Ornella, Migliarini, Sara, Maddaloni, Giacomo, Sisalli, Maria Josè, Pasqualetti, Massimo, Pollegioni, Loredano, Maione, Sabatino, Chiariotti, Lorenzo, Usiello, Alessandro

Publikováno v: The Journal of neuroscience 36 (2016): 3064–3078. doi:10.1523/JNEUROSCI.3881-15.2016
info:cnr-pdr/source/autori:Punzo, Daniela; Punzo, Daniela; Errico, Francesco; Errico, Francesco; Cristino, Luigia; Sacchi, Silvia; Sacchi, Silvia; Keller, Simona; Keller, Simona; Belardo, Carmela; Luongo, Livio; Nuzzo, Tommaso; Nuzzo, Tommaso; Imperatore, Roberta; Florio, Ermanno; Florio, Ermanno; De Novellis, Vito; Affinito, Ornella; Affinito, Ornella; Migliarini, Sara; Maddaloni, Giacomo; Sisalli, Maria Josè; Pasqualetti, Massimo; Pasqualetti, Massimo; Pollegioni, Loredano; Pollegioni, Loredano; Maione, Sabatino; Chiariotti, Lorenzo; Chiariotti, Lorenzo; Usiello, Alessandro; Usiello, Alessandro/titolo:Age-related changes in D-aspartate oxidase promoter methylation control extracellular D-aspartate levels and prevent precocious cell death during brain aging/doi:10.1523%2FJNEUROSCI.3881-15.2016/rivista:The Journal of neuroscience/anno:2016/pagina_da:3064/pagina_a:3078/intervallo_pagine:3064–3078/volume:36

The endogenous NMDA receptor (NMDAR) agonist d-aspartate occurs transiently in the mammalian brain because it is abundant during embryonic and perinatal phases before drastically decreasing during adulthood. It is well established that postnatal redu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b42915c1a57ef547eea66340a8dbb8e
https://publications.cnr.it/doc/355274