Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kellee A. Unrath"'
Autor:
Todd E. Fox, Maria C. Bewley, Kellee A. Unrath, Michelle M. Pedersen, Robert E. Anderson, Dae Young Jung, Leonard S. Jefferson, Jason K. Kim, Sarah K. Bronson, John M. Flanagan, Mark Kester
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 3, Pp 509-517 (2011)
Alterations in lipid metabolism may contribute to diabetic complications. Sphingolipids are essential components of cell membranes and have essential roles in homeostasis and in the initiation and progression of disease. However, the role of sphingol
Externí odkaz:
https://doaj.org/article/8a4d67730754453aa9e83d6fb506242a
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 314:H114-H121
Patients with atherosclerotic peripheral artery disease have an augmented pressor response to treadmill walking, but the underlying mechanisms remain poorly understood and difficult to isolate because of the confounding presence of numerous cardiovas
Autor:
John M. Flanagan, Michelle M. Pedersen, Sarah K. Bronson, Robert E. Anderson, Dae Young Jung, Kellee A. Unrath, Todd E. Fox, Mark Kester, Leonard S. Jefferson, Maria C. Bewley, Jason K. Kim
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 3, Pp 509-517 (2011)
Alterations in lipid metabolism may contribute to diabetic complications. Sphingolipids are essential components of cell membranes and have essential roles in homeostasis and in the initiation and progression of disease. However, the role of sphingol
Publikováno v:
Journal of Autoimmunity. 30:197-206
A human T-cell receptor (TcR) derived from an autoreactive T-cell specific for GAD65, from a subject at high risk for autoimmune diabetes, was introduced into HLA-DR4 transgenic mice. The source of TcR was a CD4(+) T(H)1(+) T-cell clone which respond
Publikováno v:
The Journal of biological chemistry. 286(52)
Toll-like receptor 4 (TLR4) is a component of the innate immune system that recognizes a diverse group of molecular structures, such as lipopolysaccharide (LPS) from Gram-negative bacteria. TLR4 signaling ultimately leads to activation of the transcr
Autor:
James M. Kaiser, Pingqi Dai, Robert M. Brucklacher, Mark Kester, Sarah K. Bronson, Thomas W. Gardner, Willard M. Freeman, Jeremy K. Haakenson, Hisanori Imai, Michelle M. Pedersen, Todd E. Fox, Kellee A. Unrath, Sriram S. Shanmugavelandy
Publikováno v:
Nanomedicine : nanotechnology, biology, and medicine. 9(1)
Nanoliposomal technology is a promising drug delivery system that could be employed to improve the pharmacokinetic properties of clearance and distribution in ocular drug delivery to the retina. We developed a nanoscale version of an anionic, cholest
Publikováno v:
Annals of the New York Academy of Sciences. 1103
Glutamic acid decarboxylase (GAD65) and insulin are implicated as target antigens in the pathogenesis of human diabetes through correlative measurements of humoral and cellular reactivity to them in diabetics and at-risk diabetic individuals. Recentl
Autor:
Li Wen, Kouichi Ito, Terri Daniels, Åke Lernmark, Ben A. Falk, Kellee A. Unrath, Gerald T. Nepom, John A. Gebe
Publikováno v:
Clinical immunology (Orlando, Fla.). 121(3)
We have identified for the first time an age-dependent spontaneous loss of tolerance to two self-antigenic epitopes derived from putative diabetes-associated antigens glutamic acid decarboxylase (GAD65) and glial fibrillary acidic protein (GFAP) in R