Zobrazeno 1 - 10
of 236
pro vyhledávání: '"Kelland, L.R"'
Autor:
Pors, Klaus, Paniwnyk, Z., Patterson, Laurence H., Ruparelia, K.C., Hartley, J.A., Kelland, L.R.
Novel 1- and 1,4-substituted chloroethylaminoanthraquinones with DNA binding and alkylating properties along with their respective hydroxyethylaminoanthraquinone intermediates were synthesized. Selected chloroethylaminoanthraquinones were shown to cr
Externí odkaz:
http://hdl.handle.net/10454/3164
Publikováno v:
In European Journal of Cancer 2003 39(4):532-540
Publikováno v:
In European Journal of Cancer November 2002 38(17):2309-2315
Publikováno v:
In European Journal of Cancer 2002 38(12):1653-1660
Autor:
De Vizcaya-Ruiz, A. a, *, Rivero-Muller, A. a, Ruiz-Ramirez, L. b, Kass, G.E.N. a, Kelland, L.R. c, Orr, R.M. c, Dobrota, M. a
Publikováno v:
In Toxicology in Vitro 2000 14(1):1-5
Autor:
Hiorns, L.R, Seckl, M.J, Paradinas, F, Sharp, S.Y, Skelton, L.A, Brunstrom, G, Newlands, E.S, Kelland, L.R, Leyland-Jones, B *
Publikováno v:
In Journal of Inorganic Biochemistry 1999 77(1):95-104
A new, efficient, two-step method for the synthesis of bioactive pyrroloquinolines is described. Readily available nitroquinolines, bearing the nitro moiety in the carbocyclic ring, are treated with 4-chlorophenoxyacetonitrile in the presence of pota
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::aefd7bf410ba3bbbc95486edbe9fcb36
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3022993
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3022993
A number of pyrroloisoquinolines have been prepared by reaction of 5-nitroisoquinoline with vinylmagnesium bromide followed by N-alkylation with the appropriate 2-chloro-N,N-dialkylethylamine. Their cytotoxicity was evaluated in a number of ovarian c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::3cbd041868c67cdc6201028dd24e0220
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3022899
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3022899
A new class of DNA-binding ligands (10a-f) has been synthesized and examined for DNA-binding affinity using thermal denaturation and for in vitro cytotoxicity in a number of cell lines. All the compounds were found to possess significant DNA-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::c442a7f2467f9a4eeefd9a453bbb49a8
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3023441
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3023441