Proof-of-Concept in Developing a 45% Drug Loaded Amorphous Nanoparticle Formulation.

Autor: Purohit HS; Small molecule CMC development, Drug Product Development, AbbVie Inc., North Chicago, IL, USA. Electronic address: Hitesh.purohit@abbvie.com., Zhou D; Small Molecule Drug Product Development, BeiGene, Beijing, China., Yu M; Small molecule CMC development, Drug Product Development, AbbVie Inc., North Chicago, IL, USA., Zaroudi M; MilliporeSigma, Temecula, CA, USA., Oberoi H; Small molecule CMC development, Drug Product Development, AbbVie Inc., North Chicago, IL, USA., López ALR; NBE, Drug Product Development, AbbVie Inc., North Chicago, IL, USA., Kelkar MS; Small molecule CMC development, Process Engineering, AbbVie Inc., North Chicago, IL, USA., He Y; Small molecule CMC development, Analytical Research and Development, AbbVie Inc., North Chicago, IL, USA., Gates B; Small molecule CMC development, Process Chemistry, AbbVie Inc., North Chicago, IL, USA., Nere N; Small molecule CMC development, Process Engineering, AbbVie Inc., North Chicago, IL, USA., Law D; Small molecule CMC development, Drug Product Development, AbbVie Inc., North Chicago, IL, USA. Electronic address: Devalina.law@abbvie.com.

Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 2024 Apr; Vol. 113 (4), pp. 1007-1019. Date of Electronic Publication: 2023 Oct 11.

In-line measurement of liquid-liquid phase separation boundaries using a turbidity-sensor-integrated continuous-flow microfluidic device.

Autor: Coliaie P; Department of Chemical Engineering, University of Illinois Chicago, 929 W. Taylor St., Chicago, IL 60607, USA. mrsingh@uic.edu., Prajapati A; Department of Chemical Engineering, University of Illinois Chicago, 929 W. Taylor St., Chicago, IL 60607, USA. mrsingh@uic.edu., Ali R; Department of Chemical Engineering, University of Illinois Chicago, 929 W. Taylor St., Chicago, IL 60607, USA. mrsingh@uic.edu., Boukerche M; Center of Excellence for Isolation & Separation Technologies (CoExIST), Process R&D, AbbVie Inc., North Chicago, IL 60064, USA., Korde A; Center of Excellence for Isolation & Separation Technologies (CoExIST), Process R&D, AbbVie Inc., North Chicago, IL 60064, USA., Kelkar MS; Center of Excellence for Isolation & Separation Technologies (CoExIST), Process R&D, AbbVie Inc., North Chicago, IL 60064, USA., Nere NK; Department of Chemical Engineering, University of Illinois Chicago, 929 W. Taylor St., Chicago, IL 60607, USA. mrsingh@uic.edu.; Center of Excellence for Isolation & Separation Technologies (CoExIST), Process R&D, AbbVie Inc., North Chicago, IL 60064, USA., Singh MR; Department of Chemical Engineering, University of Illinois Chicago, 929 W. Taylor St., Chicago, IL 60607, USA. mrsingh@uic.edu.

Publikováno v: Lab on a chip [Lab Chip] 2022 Jun 14; Vol. 22 (12), pp. 2299-2306. Date of Electronic Publication: 2022 Jun 14.

Patterned microfluidic devices for rapid screening of metal-organic frameworks yield insights into polymorphism and non-monotonic growth.

Autor: Coliaie P; Department of Chemical Engineering, University of Illinois Chicago, 929 W. Taylor St, Chicago, IL 60607, USA. mrsingh@uic.edu., Bhawnani RR; Department of Chemical Engineering, University of Illinois Chicago, 929 W. Taylor St, Chicago, IL 60607, USA. mrsingh@uic.edu., Prajapati A; Department of Chemical Engineering, University of Illinois Chicago, 929 W. Taylor St, Chicago, IL 60607, USA. mrsingh@uic.edu., Ali R; Department of Chemical Engineering, University of Illinois Chicago, 929 W. Taylor St, Chicago, IL 60607, USA. mrsingh@uic.edu., Verma P; Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22903, USA., Giri G; Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22903, USA., Kelkar MS; Center of Excellence for Isolation & Separation Technologies (CoExIST), Process R&D, AbbVie Inc., North Chicago, IL 60064, USA., Korde A; Center of Excellence for Isolation & Separation Technologies (CoExIST), Process R&D, AbbVie Inc., North Chicago, IL 60064, USA., Langston M; Pharmaceutics Research - Analytical Development, Takeda Pharmaceuticals International Co., Cambridge, MA 02139, USA., Liu C; Pharmaceutical Development, Biogen, Cambridge, MA 02142, USA., Nazemifard N; Pharmaceutics Research - Analytical Development, Takeda Pharmaceuticals International Co., Cambridge, MA 02139, USA., Patience D; Chemical Process Development, Biogen, Cambridge, MA 02142, USA., Rosenbaum T; Bristol-Myers Squibb Co., Drug Product Science & Technology, New Brunswick, NJ 08901, USA., Skliar D; Bristol Myers Squibb Co., Chemical & Synthetic Development, New Brunswick, NJ 08901, USA., Nere NK; Department of Chemical Engineering, University of Illinois Chicago, 929 W. Taylor St, Chicago, IL 60607, USA. mrsingh@uic.edu.; Center of Excellence for Isolation & Separation Technologies (CoExIST), Process R&D, AbbVie Inc., North Chicago, IL 60064, USA., Singh MR; Department of Chemical Engineering, University of Illinois Chicago, 929 W. Taylor St, Chicago, IL 60607, USA. mrsingh@uic.edu.

Publikováno v: Lab on a chip [Lab Chip] 2022 Jan 18; Vol. 22 (2), pp. 211-224. Date of Electronic Publication: 2022 Jan 18.

Continuous-flow, well-mixed, microfluidic crystallization device for screening of polymorphs, morphology, and crystallization kinetics at controlled supersaturation.

Autor: Coliaie P; Department of Chemical Engineering, University of Illinois at Chicago, 810 S. Clinton St., Chicago, IL 60607, USA. mrsingh@uic.edu., Kelkar MS; Center of Excellence for Isolation & Separation Technologies (CoExIST), Process R&D, AbbVie Inc., North Chicago, IL 60064, USA., Nere NK; Center of Excellence for Isolation & Separation Technologies (CoExIST), Process R&D, AbbVie Inc., North Chicago, IL 60064, USA., Singh MR; Department of Chemical Engineering, University of Illinois at Chicago, 810 S. Clinton St., Chicago, IL 60607, USA. mrsingh@uic.edu.

Publikováno v: Lab on a chip [Lab Chip] 2019 Jul 21; Vol. 19 (14), pp. 2373-2382. Date of Electronic Publication: 2019 Jun 21.

Assessing the performance of ionic liquid-assisted minimum quantity lubrication during machining of biomedical-grade stainless steel with recently developed AlTiN/TiSiXN-coated carbide tool.

Autor: Das, Anshuman, Raman, Rajan, Roy, Soumikh, Gajrani, Kishor Kumar, Ghosh, Sachidananda, Das, Sudhansu Ranjan

Publikováno v: Journal of the Brazilian Society of Mechanical Sciences & Engineering; Sep2024, Vol. 46 Issue 9, p1-27, 27p