Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Keli Liu"'
Autor:
Xinyu Gu, Xun Chen, Xuan Zhang, Keli Liu, Jing-Jing Li, Wenyu Lv, Lei Zeng, Mingjuan Wu, Weibin Zhou, Weifa Wang, Shunhua Shi, Yicheng Deng, Yunhua Li, Xinbo Gao, Rong Ju, Alexandre Dubrac, Xialin Liu, Feng Zhang
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113799- (2024)
Summary: Schlemm’s canal (SC) functions to maintain proper intraocular pressure (IOP) by draining aqueous humor and has emerged as a promising therapeutic target for glaucoma, the second-leading cause of irreversible blindness worldwide. However, o
Externí odkaz:
https://doaj.org/article/edbae61332d34f9c8f8bc204615614a1
Autor:
Yueqing Xue, Liangyu Lin, Qing Li, Keli Liu, Mingyuan Hu, Jiayin Ye, Jianchang Cao, Jingjie Zhai, Fanjun Zheng, Yu Wang, Tao Zhang, Liming Du, Cheng Gao, Guan Wang, Xuefeng Wang, Jun Qin, Xinhua Liao, Xiangyin Kong, Lydia Sorokin, Yufang Shi, Ying Wang
Publikováno v:
Advanced Science, Vol 10, Iss 4, Pp n/a-n/a (2023)
Abstract Niche for stem cells profoundly influences their maintenance and fate during tissue homeostasis and pathological disorders; however, the underlying mechanisms and tissue‐specific features remain poorly understood. Here, it is reported that
Externí odkaz:
https://doaj.org/article/c703916c64644668b7d7263e2411cdc5
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0294508 (2023)
The essential role of protein degradation by ubiquitin-proteasome system is exerted primarily for maintaining cellular protein homeostasis. The transcriptional activation of proteasomal genes by mTORC1 signaling depends on Nrf1, but whether this proc
Externí odkaz:
https://doaj.org/article/9448677b8f9641d7800d4f6a07d0649b
Publikováno v:
Redox Biology, Vol 57, Iss , Pp 102470- (2022)
To defend against a vast variety of challenges in oxygenated environments, all life forms have evolutionally established a set of antioxidants, detoxification, and cytoprotective systems during natural selection and adaptive survival, to maintain cel
Externí odkaz:
https://doaj.org/article/f500a0f2778c44ac85ebf9e3adac934b
Autor:
Lv Zhang, Pengfei Xiao, Hui Yu, Tao Zhao, SiYuan Liu, Li Yang, Yu He, Yong Luo, Xiao Wang, Wei Dong, Hui He, Duyang Wang, Keli Liu, Yi Lu
Publikováno v:
Frontiers in Ecology and Evolution, Vol 10 (2022)
Meteorological station data from 1961 to 2016 in the Sichuan Yellow River Source (SYRS) was used to analyze the trends in precipitation and temperature. The Thornthwaite Memorial model and GIS technology were used to calculate the response of pasture
Externí odkaz:
https://doaj.org/article/3487afc30ca541269cc3ca36c77e7bd6
Publikováno v:
Cell & Bioscience, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Background Interleukin-17A (IL-17) is an evolutionary conserved cytokine and best known for its role in boosting immune response. However, recent clinical researches showed that abundant IL-17 in tumor microenvironment was often associated w
Externí odkaz:
https://doaj.org/article/b135ae6ce48d40a3bc2451d052a530df
Publikováno v:
InfoMat, Vol 1, Iss 4, Pp 460-478 (2019)
Abstract Emerging two‐dimensional (2D) materials have stimulated tremendous scientific and industrial interests due to their diverse and tunable physical, chemical, and mechanical properties. The scalable production of high‐quality wafer‐scale
Externí odkaz:
https://doaj.org/article/7bd2ec8af449486aad4587bcce9a62b3
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10342 (2022)
Nrf2 (nuclear factor E2-related factor 2, encoded by Nfe2l2) acts as a master transcriptional regulator in mediating antioxidant, detoxification, and cytoprotective responses against oxidative, electrophilic, and metabolic stress, but also plays a cr
Externí odkaz:
https://doaj.org/article/f6c2831ff67c402cb976aa6e7cffad68
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Nrf1 and Nrf2, as two principal CNC-bZIP transcription factors, regulate similar but different targets involved in a variety of biological functions for maintaining cell homeostasis and organ integrity. Of note, the unique topobiological behavior of
Externí odkaz:
https://doaj.org/article/f6dad053a17f4de7a646bd096993cbee
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 6, p e1009119 (2021)
Cancer is the result of mutagenic processes that can be inferred from tumor genomes by analyzing rate spectra of point mutations, or "mutational signatures". Here we present SparseSignatures, a novel framework to extract signatures from somatic point
Externí odkaz:
https://doaj.org/article/ed06227f6ba944be9baaed2c108694e4