Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Keli L, Hippen"'
Autor:
Wenji Piao, Long Wu, Yanbao Xiong, Gregory C. Zapas, Christina M. Paluskievicz, Robert S. Oakes, Sarah M. Pettit, Margaret L. Sleeth, Keli L. Hippen, Jessica Schmitz, Philipp Ivanyi, Amol C. Shetty, Yang Song, Dejun Kong, Young Lee, Lushen Li, Marina W. Shirkey, Allison Kensiski, Aamna Alvi, Kevin Ho, Vikas Saxena, Jan H. Bräsen, Christopher M. Jewell, Bruce R. Blazar, Reza Abdi, Jonathan S. Bromberg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Regulatory T cells (Tregs) with multifaceted functions suppress anti-tumor immunity by signaling surrounding cells. Here we report Tregs use the surface lymphotoxin (LT)α1β2 to preferentially stimulate LT beta receptor (LTβR) nonclassical
Externí odkaz:
https://doaj.org/article/ec08d3585edd480ea839e96b3bc9f2de
Autor:
Wenji Piao, Lushen Li, Vikas Saxena, Jegan Iyyathurai, Ram Lakhan, Yigang Zhang, Isadora Tadeval Lape, Christina Paluskievicz, Keli L. Hippen, Young Lee, Emma Silverman, Marina W. Shirkey, Leonardo V. Riella, Bruce R. Blazar, Jonathan S. Bromberg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The Programmed death-1 (PD-1) and its ligand PD-L1 are critical checkpoints in the regulation of immune responses. Here the authors implicate PD-L1 signalling at lymphatic endothelium in the regulation of transendothelial migration of T cells.
Externí odkaz:
https://doaj.org/article/95f1ec3c1b3240e0a0c30c1a91d6a299
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for many types of cancer. Genetic disparities between donor and host can result in immune-mediated attack of host tissues, known as graft versus host disease (GVHD),
Externí odkaz:
https://doaj.org/article/8a74f734babe469ca7e47881bdd7db40
Autor:
Bing Liu, Oscar C. Salgado, Sangya Singh, Keli L. Hippen, Jason C. Maynard, Alma L. Burlingame, Lauren E. Ball, Bruce R. Blazar, Michael A. Farrar, Kristin A. Hogquist, Hai-Bin Ruan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The transcription factor Foxp3 and Stat5 modulate lineage stability and function of regulatory T (Treg) cells to promote immune homeostasis. Here the authors show that O-GlcNAcylation of Foxp3 and Stat5, mediated by O-GlcNAc transferase (OGT), is ess
Externí odkaz:
https://doaj.org/article/753e12c8c75848d7bf15336570926002
Autor:
Wenji Piao, Yanbao Xiong, Lushen Li, Vikas Saxena, Kile D. Smith, Keli L. Hippen, Christina Paluskievicz, Marina Willsonshirkey, Bruce R. Blazar, Reza Abdi, Jonathan S. Bromberg
Publikováno v:
Cell Reports, Vol 30, Iss 4, Pp 1052-1062.e5 (2020)
Summary: Regulatory T cells (Tregs) express high levels of cell surface lymphotoxin alpha beta (LTα1β2) to activate the LT beta receptor (LTβR) on the lymphatic endothelial cells (LECs), modulating LEC adhesion molecules, intercellular junctions,
Externí odkaz:
https://doaj.org/article/6876c6fb87d24c7797a8145af9f10501
Autor:
Alessandra Fiore, Stefano Ugel, Francesco De Sanctis, Sara Sandri, Giulio Fracasso, Rosalinda Trovato, Silvia Sartoris, Samantha Solito, Susanna Mandruzzato, Fulvia Vascotto, Keli L. Hippen, Giada Mondanelli, Ursula Grohmann, Geny Piro, Carmine Carbone, Davide Melisi, Rita T. Lawlor, Aldo Scarpa, Alessia Lamolinara, Manuela Iezzi, Matteo Fassan, Silvio Bicciato, Bruce R. Blazar, Ugur Sahin, Peter J. Murray, Vincenzo Bronte
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Signaling and transcriptional regulation of MDSC activity remains largely undefined. Here the authors show that monocytic MDSC immunosuppression is triggered by c-FLIP and requires NFκB, implicate this axis in cancer prognosis and response to therap
Externí odkaz:
https://doaj.org/article/c988a8bcde8c4a15aa07366b491c041d
Autor:
Alexandra Zanin-Zhorov, Sudha Kumari, Keli L. Hippen, Sarah C. Merkel, Margaret L. MacMillan, Bruce R. Blazar, Michael L. Dustin
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract In vitro induced human regulatory T cells (iTregs) have demonstrated in vivo therapeutic utility, but pathways regulating their function have not been elucidated. Here, we report that human iTregs generated in vitro from naïve cord blood ce
Externí odkaz:
https://doaj.org/article/e68bbe646c9d458cb1c2346218358f5d
Autor:
Yanbao Xiong, C. Colin Brinkman, Konrad S Famulski, Emmanuel F. Mongodin, Colin J. Lord, Keli L. Hippen, Bruce R. Blazar, Jonathan S. Bromberg
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Trans-endothelial migration (TEM) is essential for leukocyte circulation. While much is known about trans-blood endothelial migration, far less is known about trans-lymphatic endothelial migration. We established an in vitro system to evalua
Externí odkaz:
https://doaj.org/article/80899e2ada1c4615aa4c1a37324ff037
Autor:
Jeffrey S. Miller, Bruce R. Blazar, Frank Cichocki, Sarah Cooley, Bin Zhang, Zachary Davis, Julie Curtsinger, Todd Lenvik, Xianghua Luo, Skyler Hying, Amanda Lemire, Keli L. Hippen, Dhifaf Sarhan
Natural killer (NK) cells are capable of fighting viral infections and cancer. However, these responses are inhibited by immune suppressor cells in the tumor microenvironment. Tumor progression promotes the recruitment and generation of intratumoral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd0cd6c244f517801364d31cc24e8c7
https://doi.org/10.1158/2326-6066.c.6549239.v1
https://doi.org/10.1158/2326-6066.c.6549239.v1
Autor:
Jeffrey S. Miller, Bruce R. Blazar, Frank Cichocki, Sarah Cooley, Bin Zhang, Zachary Davis, Julie Curtsinger, Todd Lenvik, Xianghua Luo, Skyler Hying, Amanda Lemire, Keli L. Hippen, Dhifaf Sarhan
Supplemental Figures and Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1813c01c9458abd6c5233a909c7788
https://doi.org/10.1158/2326-6066.22539974
https://doi.org/10.1158/2326-6066.22539974