Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Keletso Maepa"'
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Malaria remains a major public health problem. With the loss of antimalarials to resistance, the malaria burden will likely continue for decades. New antimalarial scaffolds are crucial to avoid cross-resistance. Here, we present the first st
Externí odkaz:
https://doaj.org/article/83eb3cf1f04445ff916522570afe1d21
Publikováno v:
Molecules, Vol 25, Iss 7, p 1571 (2020)
With the continued loss of antimalarials to resistance, drug repositioning may have a role in maximising efficiency and accelerating the discovery of new antimalarial drugs. Bayesian statistics was previously used as a tool to virtually screen USFDA
Externí odkaz:
https://doaj.org/article/4b3871f4e07042548a4b9a0e1ffcf607
Autor:
Stefan J. Benjamin, Roger Hunter, Keletso Maepa, Timothy J. Egan, Lauren Wainwright, Jill M. Combrinck, Roxanne Openshaw
Publikováno v:
ACS Infectious Diseases. 7:362-376
A diverse series of hemozoin-inhibiting quinolines, benzamides, triarylimidazoles, quinazolines, benzimidazoles, benzoxazoles, and benzothiazoles have been found to lead to exchangeable heme levels in cultured Plasmodium falciparum (NF54) that ranged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e791a590908e85d2c227f34bc05cb47
https://doi.org/10.1021/acsinfecdis.0c00680
https://doi.org/10.1021/acsinfecdis.0c00680
Autor:
Roxanne, Openshaw, Keletso, Maepa, Stefan J, Benjamin, Lauren, Wainwright, Jill M, Combrinck, Roger, Hunter, Timothy J, Egan
Publikováno v:
ACS Infect Dis
A diverse series of hemozoin-inhibiting quinolines, benzamides, triarylimidazoles, quinazolines, benzimidazoles, benzoxazoles and benzothiazoles have been found to lead to exchangeable heme in cultured Plasmodium falciparum (NF54) that ranged over an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::561f6ebec3983193f9ee6c218c1f6e5d
https://pubmed.ncbi.nlm.nih.gov/33430579
https://pubmed.ncbi.nlm.nih.gov/33430579
Autor:
Jean Dam, Keletso Maepa, Lutete Peguy Khonde, Claire Le Manach, Janette Reader, Mariëtte van der Watt, Gregory S. Basarab, Sergio Wittlin, John Okombo, Kathryn J. Wicht, James Duffy, Aloysius T. Nchinda, Dale Taylor, André Horatscheck, Mathew Njoroge, Christel Brunschwig, Timothy J. Egan, Nina Lawrence, Ana Carolina C. de Sousa, Leslie J. Street, Kelly Chibale, Lyn-Marie Birkholtz, Ana Andrijevic, Liezl Gibhard, Tanya Paquet, Kailash P. Pawar, Paul V. Fish
Publikováno v:
J Med Chem
A series of 2,4-disubstituted imidazopyridines, originating from a SoftFocus Kinase library, was identified from a high throughput phenotypic screen against the human malaria parasite Plasmodium falciparum. Hit compounds showed moderate asexual blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0f65b29b16b46e7c416d1fc66f6377
https://europepmc.org/articles/PMC7756195/
https://europepmc.org/articles/PMC7756195/
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 54:128442
The FDA approved drug Dronabinol was identified in a previous study applying virtual screening using the haemozoin crystal as a target against malaria parasites. The active ingredient of dronabinol is synthetic tetrahydrocannabinol (THC), which is on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f4de5729a80842893815f6e2674def
https://doi.org/10.1016/j.bmcl.2021.128442
https://doi.org/10.1016/j.bmcl.2021.128442
Autor:
André Horatscheck, Ana Andrijevic, Aloysius T. Nchinda, Claire Le Manach, Tanya Paquet, Lutete Peguy Khonde, Jean Dam, Kailash Pawar, Dale Taylor, Nina Lawrence, Christel Brunschwig, Liezl Gibhard, Mathew Njoroge, Janette Reader, Mariëtte van der Watt, Kathryn Wicht, Ana Carolina C. de Sousa, John Okombo, Keletso Maepa, Timothy J. Egan, Lyn-Marie Birkholtz, Gregory S. Basarab, Sergio Wittlin, Paul V. Fish, Leslie J. Street, James Duffy, Kelly Chibale
Publikováno v:
Journal of Medicinal Chemistry. 64:1762-1762
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c147e8c41592066d856807fb5a89437
https://doi.org/10.1021/acs.jmedchem.1c00064
https://doi.org/10.1021/acs.jmedchem.1c00064
Autor:
Tameryn Stringer, Keletso Maepa, Athi Welsh, Laa-iqa Rylands, Gregory S. Smith, Dale Taylor, Kelly Chibale
Publikováno v:
European journal of medicinal chemistry. 161
Benzimidazoles, such as albendazole, thiabendazole and omeprazole have antiplasmodial activity against Plasmodium falciparum and are widely used as scaffolds for metal-based drug research. Incorporating substituents with various lipophilic and electr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38eab16388a87b09dc0151ddc961731
https://pubmed.ncbi.nlm.nih.gov/30342422
https://pubmed.ncbi.nlm.nih.gov/30342422