Reconstitution of the immune system and clinical correlates after stem cell transplantation for systemic sclerosis

Autor: Marianna Y. Kawashima-Vasconcelos, Maynara Santana-Gonçalves, Djúlio C. Zanin-Silva, Kelen C. R. Malmegrim, Maria Carolina Oliveira

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Systemic sclerosis (SSc) is a chronic autoimmune disease that includes fibrosis, diffuse vasculopathy, inflammation, and autoimmunity. Autologous hematopoietic stem cell transplantation (auto-HSCT) is considered for patients with severe and progressi

Externí odkaz: https://doaj.org/article/4e7b01ec25764a7a8b1d198ff007f2a3

Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies

Autor: Nádia de Cássia Noronha, Amanda Mizukami, Carolina Caliári-Oliveira, Juçara Gastaldi Cominal, José Lucas M. Rocha, Dimas Tadeu Covas, Kamilla Swiech, Kelen C. R. Malmegrim

Publikováno v: Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-21 (2019)

Abstract Multipotent mesenchymal stromal cells (MSC) have been widely explored for cell-based therapy of immune-mediated, inflammatory, and degenerative diseases, due to their immunosuppressive, immunomodulatory, and regenerative potentials. Preclini

Externí odkaz: https://doaj.org/article/3b2ec96227cd4be081df40d2750b7ce1

Correction to: Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies

Autor: Nádia de Cássia Noronha, Amanda Mizukami, Carolina Caliári-Oliveira, Juçara Gastaldi Cominal, José Lucas M. Rocha, Dimas Tadeu Covas, Kamilla Swiech, Kelen C. R. Malmegrim

Publikováno v: Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-1 (2019)

The original article [1] contained an error in the presentation of the first author’s name, Nádia de Cássia Noronha. This has now been corrected.

Externí odkaz: https://doaj.org/article/e07b220ed8ac41f9b85d8026d2328391

Emerging CAR T cell therapies: clinical landscape and patent technological routes

Autor: Dimas Tadeu Covas, Kelen C. R. Malmegrim, Cristiano Gonçalves Pereira, Kamilla Swiech, Geciane Silveira Porto, Virgínia Picanço-Castro

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Hum Vaccin Immunother

The purpose of this study is to mine CAR-T patents and therapies under development, to design a landscape of the sector and to understand key therapy segments and their current trends. The study analyzed the entire market, consisting of 1624 patent f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbc8b29f3acde8a00aed63bb01d6f04
https://doi.org/10.1080/21645515.2019.1689744

Bone Marrow Mesenchymal Stromal Cells Isolated from Multiple Sclerosis Patients have Distinct Gene Expression Profile and Decreased Suppressive Function Compared with Healthy Counterparts

Autor: Gislane L. V. De Oliveira Ph.D., Kalil W. A. De Lima, Amanda M. Colombini, Daniel G. Pinheiro, Rodrigo A. Panepucci, Patrícia V. B. Palma, Doralina G. Brum, Dimas T. Covas, Belinda P. Simões, Maria C. De Oliveira, Eduardo A. Donadi, Kelen C. R. Malmegrim

Publikováno v: Cell Transplantation, Vol 24 (2015)

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system, due to an immune reaction against myelin proteins. Multipotent mesenchymal stromal cells (MSCs) present immunosuppressive effects and have been used f

Externí odkaz: https://doaj.org/article/646b6ddaab764dba9addd12d4cf4462e