Premature trial discontinuation often not accurately reflected in registries: comparison of registry records with publications

Autor: Erik von Elm, Roy Frei, Arnav Agarwal, Reem Alturki, Stefan Schandelmaier, Lotty Hooft, Belinda von Niederhäusern, Matthias Briel, Neera Bhatnagar, Kelechi K Olu

Publikováno v: Journal of Clinical Epidemiology
Europe PubMed Central
Journal of Clinical Epidemiology, 81, 56. Elsevier USA

Background One quarter of randomized clinical trials (RCTs) are prematurely discontinued and frequently remain unpublished. Trial registries can document whether a trial is ongoing, suspended, discontinued, or completed and therefore represent an imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023c37ae3c7fd0c382f14bd328ecd3fc
http://www.sciencedirect.com/science/article/pii/S0895435616304036

Niacin for primary and secondary prevention of cardiovascular events

Autor: Lars G. Hemkens, Alain J Nordmann, Armon Arpagaus, Kelechi K Olu, Matthias Briel, Ramon Saccilotto, Stefan Schandelmaier

Publikováno v: The Cochrane Library

Background Nicotinic acid (niacin) is known to decrease LDL-cholesterol, and triglycerides, and increase HDL-cholesterol levels. The evidence of benefits with niacin monotherapy or add-on to statin-based therapy is controversial. Objectives To assess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd68b7194a6927feca02cf4a3300069
https://doi.org/10.1002/14651858.cd009744.pub2

Agreements between industry and academia on publication rights: a retrospective study of protocols and publications of randomized clinical trials

Autor: Gordon H. Guyatt, Kari A.O. Tikkinen, Jason W. Busse, Per Olav Vandvik, Ramon Saccilotto, Francois Lamontagne, Yuki Tomonaga, Elie A. Akl, Heiner C. Bucher, Heike Raatz, Erik von Elm, Lorenzo Moja, Matthias Schwenkglenks, Theresa Bengough, Anette Blümle, Shanil Ebrahim, Mihaela Stegert, Dirk Bassler, Bernard Burnand, Stefan Schandelmaier, Matthias Briel, Bradley C. Johnston, Xin Sun, John J. You, Alonso Carrasco-Labra, Viktoria Gloy, Dominik Mertz, Benjamin Kasenda, Markus Faulhaber, Lars G. Hemkens, Alain Amstutz, Ignacio Ferreira-González, Sohail M. Mulla, Martin A. Walter, Kelechi K Olu, Ignacio Neumann, Alain J Nordmann, Joerg J Meerpohl

Publikováno v: Plos Medicine, vol. 13, no. 6, pp. e1002046
Kasenda, Benjamin; von Elm, Erik; You, John J; Blümle, Anette; Tomonaga, Yuki; Saccilotto, Ramon; Amstutz, Alain; Bengough, Theresa; Meerpohl, Joerg J; Stegert, Mihaela; Olu, Kelechi K; Tikkinen, Kari A O; Neumann, Ignacio; Carrasco-Labra, Alonso; Faulhaber, Markus; Mulla, Sohail M; Mertz, Dominik; Akl, Elie A; Bassler, Dirk; Busse, Jason W; ... (2016). Agreements between Industry and Academia on Publication Rights: A Retrospective Study of Protocols and Publications of Randomized Clinical Trials. PLoS medicine, 13(6), e1002046. Public Library of Science 10.1371/journal.pmed.1002046
PLOS Medicine
PLoS Medicine, Vol 13, Iss 6, p e1002046 (2016)
PLoS Medicine

Background Little is known about publication agreements between industry and academic investigators in trial protocols and the consistency of these agreements with corresponding statements in publications. We aimed to investigate (i) the existence an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a7513b093608c94459014bed114cb47
https://www.zora.uzh.ch/id/eprint/128301/

Premature Discontinuation of Randomized Trials in Critical and Emergency Care: A Retrospective Cohort Study

Autor: Theresa Bengough, Deborah J. Cook, Erik von Elm, Shanil Ebrahim, Mihaela Stegert, John J. You, Alonso Carrasco-Labra, Alain Amstutz, Matthias Briel, Maureen O. Meade, Matthias Schwenkglenks, Bradley C. Johnston, Per Olav Vandvik, Yuki Tomonaga, Viktoria Gloy, Heike Raatz, Elie A. Akl, Bernard Burnand, Stefan Schandelmaier, Jason W. Busse, Martin A. Walter, Francois Lamontagne, Ramon Saccilotto, Sohail M. Mulla, Heiner C. Bucher, Anette Blümle, Dirk Bassler, Lorenzo Moja, Xin Sun, Lars G. Hemkens, Ignacio Ferreira-González, Rachel Rosenthal, Markus Faulhaber, Dominik Mertz, Alain J Nordmann, Joerg J Meerpohl, Kelechi K Olu, Benjamin Kasenda, Kari A.O. Tikkinen, Ignacio Neumann

Publikováno v: Schandelmaier, Stefan; von Elm, Erik; You, John J; Blümle, Anette; Tomonaga, Yuki; Lamontagne, Francois; Saccilotto, Ramon; Amstutz, Alain; Bengough, Theresa; Meerpohl, Joerg J; Stegert, Mihaela; Olu, Kelechi K; Tikkinen, Kari A O; Neumann, Ignacio; Carrasco-Labra, Alonso; Faulhaber, Markus; Mulla, Sohail M; Mertz, Dominik; Akl, Elie A; Sun, Xin; ... (2016). Premature Discontinuation of Randomized Trials in Critical and Emergency Care: A Retrospective Cohort Study. Critical care medicine, 44(1), pp. 130-137. Lippincott Williams & Wilkins 10.1097/CCM.0000000000001369
Critical Care Medicine

OBJECTIVES Randomized clinical trials that enroll patients in critical or emergency care (acute care) setting are challenging because of narrow time windows for recruitment and the inability of many patients to provide informed consent. To assess the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbdf284232d5dac70aee7a648bbdb10

Cardiovascular effects and safety of long-term colchicine treatment: Cochrane review and meta-analysis

Autor: Lars G. Hemkens, Armon Arpagaus, Alain J Nordmann, Hannah Ewald, Viktoria Gloy, Kelechi K Olu, Mark Nidorf, Matthias Briel, Dominik Glinz

Publikováno v: Heart (British Cardiac Society). 102(8)

Colchicine is an old anti-inflammatory drug that has shown substantial cardiovascular benefits in recent trials. We systematically reviewed cardiovascular benefits and harms of colchicine in any population and specifically in patients with high cardi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7505a8a3ee0e8db438586d6bf7fca8ac
https://pubmed.ncbi.nlm.nih.gov/26839067