Increased Sensitivity to Interferon-α in Psoriatic T Cells

Autor: Thorbjørn Krejsgaard, Karsten W. Eriksen, Keld Kaltoft, Niels Ødum, Lone Skov, Carsten Geisler, Paola Lovato

Publikováno v: Journal of Investigative Dermatology. 125:936-944

Psoriasis is a chronic inflammatory skin disease characterized by abnormal epidermal proliferation. Several studies have shown that skin-infiltrating activated T cells and cytokines play a pivotal role during the initiation and maintenance of the dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba2501f245d2f54586d7ed6384e72a6
https://doi.org/10.1111/j.0022-202x.2005.23864.x

SHP2 REGULATES IL-2 INDUCED MAPK ACTIVATION, BUT NOT Stat3 OR Stat5 TYROSINE PHOSPHORYLATION, IN CUTANEOUS T CELL LYMPHOMA CELLS

Autor: Niels Ødum, Keld Kaltoft, Tomas Mustelin, Qian Zhang, Mariusz A. Wasik, Anders Woetmann, Johannes Brockdorff, Carsten Röpke

Publikováno v: Cytokine. 20:141-147

The phosphotyrosine phosphatase SHP2 has been suggested to regulate activation of MAPK, Stat3, and Stat5 in several experimental models. In this study we investigated the role of SHP2 in IL-2 induced activation of MAPK and the Stat proteins using the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeab1268452ba80ebb8fbbd50abf22e1
https://doi.org/10.1006/cyto.2002.1986

STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma

Autor: Keld Kaltoft, Christine Brender, Mariusz A. Wasik, Niels Ødum, Mette Olaf Nielsen, Nils Billestrup, Gitte Mikkelsen, Qian Zhang

Publikováno v: Brender, C, Nielsen, M, Kaltoft, K, Mikkelsen, G, Zhang, Q, Wasik, M, Billestrup, N & Odum, N 2001, ' STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma ' Blood, vol. 97, no. 4, pp. 1056-1062 .

A characteristic feature of neoplastic transformation is the loss of external control by cytokines and extracellular matrix of cellular differentiation, migration, and mitogenesis. Because suppressors of cytokine signaling (SOCS) proteins are negativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6a7c7b41cc169fa5632499588955e0
https://doi.org/10.1182/blood.v97.4.1056

Cytokine-Driven Immortalization of in vitro Activated Human T Lymphocytes

Autor: Keld Kaltoft

Publikováno v: Experimental and Clinical Immunogenetics. 15:84-89

Like other normal human somatic cells, T lymphocytes are believed to have a finite in vitro life span. However, continuous T lymphocyte cell lines can often be established from chronic inflammatory skin diseases when the culture medium is supplemente

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b9bfc498f95df261a8c20b31fdeb546
https://doi.org/10.1159/000019058

Common clonal chromosome aberrations in cytokine-dependent continuous human T-lymphocyte cell lines

Autor: Keld Kaltoft, Birgit Holm Hansen, Kristian Thestrup-Pedersen, Søren Pedersen, Charlotte B. Pedersen

Publikováno v: Cancer Genetics and Cytogenetics. 85:68-71

Antigen-mediated T-cell proliferation is a transient phenomenon. Like other somatic cells, T lymphocytes generally show replicative senescence in vitro. However, we here show that cytokine-dependent continuous (immortal) T-cell lines can be establish

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0fc1bd3f11a8aa7a01ab3e748191db
https://doi.org/10.1016/0165-4608(95)00118-2