Výsledky vyhledávání - "Kelcie A. Zegalia"

Interactions between Viperin, Vesicle-Associated Membrane Protein A, and Hepatitis C Virus Protein NS5A Modulate Viperin Activity and NS5A Degradation

Autor: Soumi Ghosh, Robert T. Kennedy, Timothy J. Grunkemeyer, E. Neil G. Marsh, Arti B. Dumbrepatil, Kelcie A. Zegalia, Ayesha M. Patel

Publikováno v: Biochemistry. 59(6)

The radical SAM enzyme, viperin, exerts a wide range of antiviral effects through both the synthesis of the antiviral nucleotide 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) and through its interactions with various cellular and viral proteins. Here we inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708641c5ba8ccb81d45764f095b228ae
https://pubmed.ncbi.nlm.nih.gov/31977203

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Targeting Viperin to the Mitochondrion Inhibits the Thiolase Activity of the Trifunctional Enzyme Complex

Autor: Arti B. Dumbrepatil, Kelcie A. Zegalia, E. Neil G. Marsh, Robert T. Kennedy, Keerthi Sajja

Publikováno v: J Biol Chem

Understanding the mechanisms by which viruses evade host cell immune defenses is important for developing improved antiviral therapies. In an unusual twist, human cytomegalovirus (HCMV) co-opts the antiviral radical SAM enzyme, viperin (Virusinhibito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84bbbbe96bed65f1692d32e50549dea1
https://doi.org/10.1101/824425

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Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6, coupling innate immune signaling to antiviral ribonucleotide synthesis

Autor: J. Damon Hoff, Paige A. Malec, E. Neil G. Marsh, Kelcie A. Zegalia, Arti B. Dumbrepatil, Soumi Ghosh, Robert T. Kennedy

Virus-inhibitory protein, endoplasmic reticulum-associated, interferon-inducible (viperin) is a radical SAM enzyme that plays a multifaceted role in the cellular antiviral response. Viperin has recently been shown to catalyze the SAM-dependent format

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e34d434134fce3a64cfca6bb154ed78
https://europepmc.org/articles/PMC6497957/

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Interactions between Viperin, IRAK1 andTRAF6 couple innate immune signaling to antiviral ribonucleotide synthesis

Autor: Kelcie A. Zegalia, Arti B. Dumbrepatil, Soumi Ghosh, E. Neil G. Marsh, J. Damon Hoff, Paige A. Malec, Ayesha M. Patel, Robert T. Kennedy

SummaryViperin is a radical S-adenosylmethionine (SAM) enzyme that plays a multifaceted role in the cellular antiviral response. Viperin was recently shown to catalyze the SAM-dependent formation of 3′-deoxy-3′,4′-didehydro-CTP (ddhCTP), which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd490cb9c5ed4da7562d5dd3dc9ed89e
https://doi.org/10.1101/318840

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Controllable Formation of Heterotrimetallic Coordination Compounds: Systematically Incorporating Lanthanide and Alkali Metal Ions into the Manganese 12-Metallacrown-4 Framework

Autor: Connor I. Daly, Jeff W. Kampf, Ruthairat Nimthong, Thaddeus T. Boron, Gregory M. Ferrence, Kelcie A. Zegalia, Jacob C. Lutter, Michael R. Azar, Vincent L. Pecoraro, Matthias Zeller, Curtis M. Zaleski

Publikováno v: Inorganic Chemistry. 53:1729-1742

The inclusion of Ln(III) ions into the 12-MC-4 framework generates the first heterotrimetallic complexes of this molecular class. The controllable and deliberate preparations of these compounds are demonstrated through 12 crystal structures of the Ln

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e08168e3a86f078b30d81d2910476fc
https://doi.org/10.1021/ic402865p

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