The early proximal αβ TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network.

Autor: Neier SC; Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA.; Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN, USA., Ferrer A; Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA., Wilton KM; Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA.; Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN, USA.; Medical Scientist Training Program, Mayo Clinic College of Medicine, Rochester, MN, USA., Smith SEP; Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA., Kelcher AMH; Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA.; Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN, USA.; Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA., Pavelko KD; Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA., Canfield JM; Molecular Pathogenesis and Therapeutics PhD Graduate Program, University of Missouri, Columbia, MO, USA., Davis TR; Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA., Stiles RJ; Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA., Chen Z; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia., McCluskey J; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia., Burrows SR; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.; School of Medicine, University of Queensland, Brisbane, Queensland 4006, Australia., Rossjohn J; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.; ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.; Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK., Hebrink DM; Thoracic Diseases Research Unit, Division of Pulmonary Critical Care and Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA., Carmona EM; Thoracic Diseases Research Unit, Division of Pulmonary Critical Care and Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA., Limper AH; Thoracic Diseases Research Unit, Division of Pulmonary Critical Care and Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA., Kappes DJ; Blood Cell Development and Cancer Keystone, Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Wettstein PJ; Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA.; Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA., Johnson AJ; Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA.; Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA., Pease LR; Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA., Daniels MA; Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, MO, USA.; Department of Surgery, School of Medicine, University of Missouri, Columbia, MO, USA., Neuhauser C; University of Minnesota Informatics Institute, Minneapolis, MN, USA., Gil D; Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, MO, USA. schruma@health.missouri.edu gilpagesd@health.missouri.edu.; Department of Surgery, School of Medicine, University of Missouri, Columbia, MO, USA.; Department of Bioengineering, College of Engineering, University of Missouri, Columbia, MO, USA., Schrum AG; Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, MO, USA. schruma@health.missouri.edu gilpagesd@health.missouri.edu.; Department of Surgery, School of Medicine, University of Missouri, Columbia, MO, USA.; Department of Bioengineering, College of Engineering, University of Missouri, Columbia, MO, USA.

Publikováno v: Science immunology [Sci Immunol] 2019 Feb 15; Vol. 4 (32).