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Akademický článek

SMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in disease

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)

Abstract The interplay between 3D chromatin architecture and gene silencing is incompletely understood. Here, we report a novel point mutation in the non-canonical SMC protein SMCHD1 that enhances its silencing capacity at endogenous developmental ta

Externí odkaz: https://doaj.org/article/4b268abe87144921872eecf80d018c13

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Akademický článek

Transcriptional profiling of the epigenetic regulator Smchd1

Autor: Ruijie Liu, Kelan Chen, Natasha Jansz, Marnie E. Blewitt, Matthew E. Ritchie

Publikováno v: Genomics Data, Vol 7, Iss , Pp 144-147 (2016)

Smchd1 is an epigenetic repressor with important functions in healthy cellular processes and disease. To elucidate its role in transcriptional regulation, we performed two independent genome-wide RNA-sequencing studies comparing wild-type and Smchd1

Externí odkaz: https://doaj.org/article/9a2fca80da2a4c0da5a0062418d86899

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Abstract 4259: PT199, a next generation anti-CD73 mAb that inhibits both membrane-bound and soluble CD73 activity to completion without 'hook effect'

Autor: Haiqun (John) Jia, Jack Li, Fen Pei, Lorraine Greenwood, Lauren Pejza, Yan Long, Kelan Chen, Jessica Perer, Ming Wang, Hui Zou

Publikováno v: Cancer Research. 82:4259-4259

CD73, also known as ecto-5’-nucleotidase, is implicated in promoting immunosuppressive tumor microenvironment (TME) through production of adenosine. The first generation of anti-CD73 therapeutic antibodies currently in clinical studies have largely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a0589dca6757164ab9a7dcfe8f9fc9e
https://doi.org/10.1158/1538-7445.am2022-4259

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Abstract 2908: PT217, an anti-DLL3/anti-CD47 bispecific antibody, exhibits anti-tumor activity through novel mechanisms of action

Autor: Haiqun(John) Jia, Dorthy Fang, Molly Lobsinger, Yan Long, Kelan Chen, Albert Lam, Yangyang Guo, Kaisa Selesniemi, Ming Wang, Hui Zou

Publikováno v: Cancer Research. 82:2908-2908

Small cell lung cancer (SCLC) is the most lethal subtype of lung cancers with few patients surviving more than 5 years from diagnosis. While SCLC initially responds well to standard chemotherapy treatment, chemotherapy-resistant recurrence is charact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bead8580f747a0f4e0f9182fb0e2503
https://doi.org/10.1158/1538-7445.am2022-2908

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Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid–binding residues

Autor: James M. Murphy, Andrew I. Webb, Tracy A. Willson, Jarrod J. Sandow, Alexandra D. Gurzau, Patrick J. Hennessy, Denise A. Heckmann, Samuel N. Young, Marnie E. Blewitt, Peter E. Czabotar, Iromi Wanigasuriya, Richard W Birkinshaw, Megan Iminitoff, Ruoyun Wang, Kelan Chen

Publikováno v: Science Signaling. 13

Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) is an epigenetic regulator in which polymorphisms cause the human developmental disorder, Bosma arhinia micropthalmia syndrome, and the degenerative disease, facioscapu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45a51a5545b8da2159c6452773b69ae
https://doi.org/10.1126/scisignal.aaz5599

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An optimized SEC-SAXS system enabling high X-ray dose for rapid SAXS assessment with correlated UV measurements for biomolecular structure analysis

Autor: Christopher A. McDevitt, J.R. Keown, Serena A.J. Watkin, Jill Trewhella, Adrian Hawley, Bostjan Kobe, Lachlan W. Casey, Stephen T. Mudie, Kelan Chen, James M. Murphy, Timothy M. Ryan, Zhenyao Luo, Vesna Samardzic Boban, F. Grant Pearce, David C. Goldstone, Nigel Kirby

Publikováno v: Journal of Applied Crystallography. 51:97-111

A new optimized size exclusion chromatography small-angle X-ray scattering (SEC-SAXS) system for biomolecular SAXS at the Australian Synchrotron SAXS/WAXS beamline has been developed. The compact configuration reduces sample dilution to maximize sens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b31713982aa7442fcee2ee2ce612bf7
https://doi.org/10.1107/s1600576717017101

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How do mutations in epigenetic regulators contribute to disease?

Autor: Kelan Chen, Marnie E. Blewitt

Publikováno v: The Biochemist. 39:20-23

Imagine you are a scientist and receive an email from a patient inquiring whether carrying a particular mutation is going to affect their offspring. This may sound unrealistic, yet this is the sort of thing that will happen increasingly as sometimes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5a3603764a57afc7927d7d14c97e75c
https://doi.org/10.1042/bio03905020

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