Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Keke Dong"'
Autor:
Guangjian Yang, Xuezhi Hao, Jiaqi Hu, Keke Dong, Haiyan Xu, Lu Yang, Shuyang Zhang, Yaning Yang, Fei Xu, Junling Li, Yan Wang
Publikováno v:
Journal of the National Cancer Center, Vol 1, Iss 4, Pp 139-146 (2021)
Human epidermal growth factor receptor 2 (HER2) amplification or activating mutations are found in 1.6%–4% of non-small cell lung cancer (NSCLC). Pyrotinib has been reported to have better potency in NSCLC patients with HER2 exon 20 insertion (ex20
Externí odkaz:
https://doaj.org/article/e0a10c2a260d404fa245111e6bbb387b
Autor:
Chang Seok Lee, Amy D. Hanna, Hui Wang, Adan Dagnino-Acosta, Aditya D. Joshi, Mark Knoblauch, Yan Xia, Dimitra K. Georgiou, Jianjun Xu, Cheng Long, Hisayuki Amano, Corey Reynolds, Keke Dong, John C. Martin, William R. Lagor, George G. Rodney, Ergun Sahin, Caroline Sewry, Susan L. Hamilton
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Mutations in the RyR1 channel cause core myopathies. Here the authors show that ER stress and the unfolded protein response underlie the pathology caused by a common RyR1 channel mutation, and show that treatment with a chemical chaperone restores mu
Externí odkaz:
https://doaj.org/article/8a7faf752203416684267602ebe0758b
Autor:
Jiaqi Hu, Guangjian Yang, Xuezhi Hao, Lu Yang, Yaning Yang, Yan Wang, Haiyan Xu, Keke Dong, Shuyang Zhang, Junling Li, Fei Xu
Publikováno v:
Journal of the National Cancer Center, Vol 1, Iss 4, Pp 139-146 (2021)
Human epidermal growth factor receptor 2 (HER2) amplification or activating mutations are found in 1.6%–4% of non-small cell lung cancer (NSCLC). Pyrotinib has been reported to have better potency in NSCLC patients with HER2 exon 20 insertion (ex20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ed4f5d4f3aca048b4786763e272ab0
http://www.sciencedirect.com/science/article/pii/S2667005421000363
http://www.sciencedirect.com/science/article/pii/S2667005421000363
Autor:
Corey L. Reynolds, Amy D. Hanna, Hui J. Wang, Yan Xia, George G. Rodney, Cheng Long, William R. Lagor, Keke Dong, Hisayuki Amano, Ergun Sahin, John C. Martin, Dimitra K. Georgiou, Mark Knoblauch, Aditya D. Joshi, Adan Dagnino-Acosta, Chang Seok Lee, Susan L. Hamilton, Jianjun Xu, Caroline Sewry
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications
Mutations in the RYR1 gene cause severe myopathies. Mice with an I4895T mutation in the type 1 ryanodine receptor/Ca2+ release channel (RyR1) display muscle weakness and atrophy, but the underlying mechanisms are unclear. Here we show that the I4895T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e84c20b95dcf268f683054bd66cc5d
https://doaj.org/article/8a7faf752203416684267602ebe0758b
https://doaj.org/article/8a7faf752203416684267602ebe0758b
Publikováno v:
Journal of Molecular Graphics and Modelling. 68:57-67
Roscovitine derivatives are potent inhibitors of cyclin-dependent kinase 5 (CDK5), but they exhibit different activities, which has not been understood clearly up to now. On the other hand, the task of drug design is difficult because of the fuzzy bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2505d429e31b6848a3c77ac954f3cc65
https://doi.org/10.1016/j.jmgm.2016.06.007
https://doi.org/10.1016/j.jmgm.2016.06.007
Revealing selectivity mechanism of cyclin-dependent kinases (CDK) and their inhibitors is an important issue to develop potential anticancer drugs. The substituted 4-(Pyrazol-4-yl)-pyrimidines are potent inhibitors of CDK4 but not of the highly homol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b2eac46266e38d6dad9f0917ecadb2
Publikováno v:
Transactions of Nonferrous Metals Society of China. 22:s519-s527
The dynamic recrystallization (DRX) rules are the significant foundation for the effective control of DRX behavior, consequently achieving fine grains and qualified microstructure in the needle piercing extrusion for AISI304 stainless steel pipe. A r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a48ffbfb62d0977f6cdbf65eb36b399b
https://doi.org/10.1016/s1003-6326(12)61755-5
https://doi.org/10.1016/s1003-6326(12)61755-5
Autor:
Qing Cheng, Johanna T. Lanner, Robert T. Dirksen, George G. Rodney, Susan L. Hamilton, Zanwen Chen, Tanner O. Monroe, Chang Seok Lee, Arturo Santillan, Joshua M. Oakes, Laurie J. Goodyear, Viktor Yarotskyy, Dimitra K. Georgiou, Alina Ainbinder, Adan Dagnino-Acosta, Iskander I. Ismailov, Keke Dong, Aditya D. Joshi
Publikováno v:
Nature medicine
Mice with a knock-in mutation (Y524S) in the type I ryanodine receptor (Ryr1), a mutation analogous to the Y522S mutation that is associated with malignant hyperthermia in humans, die when exposed to short periods of temperature elevation (≥37 °C)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bbf216e1e317b385d7655f89825848
http://europepmc.org/articles/PMC3274651
http://europepmc.org/articles/PMC3274651
Autor:
George G. Rodney, Mark Knoblauch, Christine Beeton, Pumin Zhang, Robert T. Dirksen, Amy D. Hanna, Mary E. Dickinson, Susan L. Hamilton, Adan Dagnino-Acosta, Iskander I. Ismailov, Dimitra K. Georgiou, Ted Tran, Johanna T. Lanner, Viktor Yarotskyy, Alla D. Lyfenko, Michael W. Swank, Cheng Long, Chang Seok Lee, Keke Dong, Ross A. Poché
Publikováno v:
Skeletal Muscle
Background Ca2+ influx through CaV1.1 is not required for skeletal muscle excitation-contraction coupling, but whether Ca2+ permeation through CaV1.1 during sustained muscle activity plays a functional role in mammalian skeletal muscle has not been a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ca179b6b70d9f640dbc6687433ace8
https://doi.org/10.1186/s13395-014-0027-1
https://doi.org/10.1186/s13395-014-0027-1
Publikováno v:
Journal of Molecular Modeling. 20
We apply molecular docking, molecular dynamics (MD) simulation, and binding free energy calculation to investigate and reveal the binding mechanism between five xanthine inhibitors and DPP-4. The electrostatic and van der Waals interactions of the fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43aba4a8590027c31882f126eb84c861
https://doi.org/10.1007/s00894-014-2075-1
https://doi.org/10.1007/s00894-014-2075-1