Ectopic BH3-only protein Bim acts as a cochaperone to positively regulate Hsp70 in yeast

Autor: Zhichao Zhang, Tong Ji, Keke Cao, Hong Zhang, Hao Pan, Ting Song, Ziqian Wang, Yafei Guo

Publikováno v: The Journal of Biochemistry. 170:539-545

The chaperone heat shock protein 70 (Hsp70) is conserved from bacteria to humans and is crucial for avoiding protein misfolding under stress. Bim functions, mainly as one of the B-cell lymphoma 2 (Bcl-2) family proapoptotic members, were identified t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e9d806e912acf8078a2fb91b7a359e6
https://doi.org/10.1093/jb/mvab073

A 'Three‐in‐One' Multifunctional Probe for Bcl‐2/Mcl‐1 Profiling and Visualizing in Situ

Autor: Ziqian Wang, Zongwei Guo, Xiaodong Zhang, Ting Song, Keke Cao, Zhichao Zhang, Junjie Zhu, Nianzhe He

Publikováno v: Zhang, X, Wang, Z, Guo, Z, Song, T, He, N, Zhu, J, Cao, K & Zhang, Z 2021, ' A "three-in-one" multi-functional probe for Bcl-2/Mcl-1 profiling and visualizing in situ ', ChemBioChem, vol. 22, no. 2, pp. 326-329 . https://doi.org/10.1002/cbic.202000441

Bcl-2 and Mcl-1, the two arms of the anti-apoptotic Bcl-2 family proteins, have been identified as key regulators of apoptosis and effective therapeutic targets of cancer. However, no small molecular probe is capable of profiling and visualizing both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03d14a629b9bf136acd84ff45713646
https://doi.org/10.1002/cbic.202000441

Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands

Autor: Zhichao Zhang, Junjie Zhu, Ziqian Wang, Yafei Guo, Nianzhe He, Zongwei Guo, Ting Song, Keke Cao, Xiaodong Zhang, Anhui Wang, Cuili Niu

Publikováno v: Journal of Medicinal Chemistry. 62:8152-8163

Proteolysis targeting chimera (PROTAC) recruits an E3 ligase to a target protein to induce its ubiquitination and subsequent degradation. We reported success in the development of two PROTACs (C3 and C5) that potently and selectively induce the degra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fb8dd5be3b73de5abad0ed2f2e72be
https://doi.org/10.1021/acs.jmedchem.9b00919

Sequencing Games with Slack Due Windows and Group Technology Considerations

Autor: T.C.E. Cheng, Sai Liu, Keke Cao, Min Ji, Xiaolin Zhang

Publikováno v: Journal of the Operational Research Society. 68:121-133

We study sequencing situations in which the customers are initially sequenced to be served by a single server. We consider both slack due windows and group technology simultaneously. We introduce two division rules to divide among the customers the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65d4f69d968fda56543d7c49aab26298
https://doi.org/10.1057/s41274-016-0010-9

[Snacks consumption among residents in Shenzhen City]

Autor: Qinggang, Shang, Keke, Cao, Jiazhang, Xu, Xueli, Yuan, Zhipeng, Zhuo, Jian, Xu, Peng, Pan

Publikováno v: Wei sheng yan jiu = Journal of hygiene research. 43(4)

To describe the status of snacks consumption among residents in Shenzhen.By a multiple stage probability proportionate to size sampling, 12 communities were randomly selected from 8 districts of Shenzhen based on population proportion. In the second

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6163f373921dc754f10883ca5a914ac3
https://pubmed.ncbi.nlm.nih.gov/25199284