Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Keke C. Fairfax"'
Autor:
Yinshen Wee, Junhua Wang, Emily C. Wilson, Coulson P. Rich, Aaron Rogers, Zongzhong Tong, Evelyn DeGroot, Y. N. Vashisht Gopal, Michael A. Davies, H. Atakan Ekiz, Joshua K. H. Tay, Chris Stubben, Kenneth M. Boucher, Juan M. Oviedo, Keke C. Fairfax, Matthew A. Williams, Sheri L. Holmen, Roger K. Wolff, Allie H. Grossmann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Tumour-host immune interactions lead to complex changes in the tumour microenvironment (TME), impacting progression, metastasis and response to therapy. While it is clear that cancer cells can have the capacity to alter immune landscapes, ou
Externí odkaz:
https://doaj.org/article/e7e3f29dc417478dac14dd2ee69fe482
Autor:
Diana Cortes-Selva, Andrew F. Elvington, Andrew Ready, Bartek Rajwa, Edward J. Pearce, Gwendalyn J. Randolph, Keke C. Fairfax
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Hepatic macrophages play an essential role in the granulomatous response to infection with the parasitic helminth Schistosoma mansoni, but the transcriptional changes that underlie this effect are poorly understood. To explore this, we sorted the two
Externí odkaz:
https://doaj.org/article/4ddd6ce476374344bff6a5ead3ac466c
Autor:
Diana Cortés-Selva, Lisa Gibbs, Andrew Ready, H Atakan Ekiz, Ryan O'Connell, Bartek Rajwa, Keke C Fairfax
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009260 (2021)
Epidemiological studies have identified a correlation between maternal helminth infections and reduced immunity to some early childhood vaccinations, but the cellular basis for this is poorly understood. Here, we investigated the effects of maternal
Externí odkaz:
https://doaj.org/article/446d0b8b30734010a24e8f897ced3428
Autor:
Diana Cortes-Selva, Lisa Gibbs, J Alan Maschek, Marcia Nascimento, Tyler Van Ry, James E Cox, Eyal Amiel, Keke C Fairfax
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009198 (2021)
Macrophages have a defined role in the pathogenesis of metabolic disease and cholesterol metabolism where alternative activation of macrophages is thought to be beneficial to both glucose and cholesterol metabolism during high fat diet induced diseas
Externí odkaz:
https://doaj.org/article/96328531bcf34c72b676ecc76187576b
Publikováno v:
bioRxiv
Infections during pregnancy with pathogens such as helminths correlate with altered immune responses to common childhood immunizations. However, the molecular mechanisms that underlie this remain unknown. Using our murine model of maternal schistosom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a273389ba5ffd6fceca4db4a62ac45
https://doi.org/10.1101/2023.02.13.528357
https://doi.org/10.1101/2023.02.13.528357
Autor:
Diana Cortes-Selva, Keke C. Fairfax
Publikováno v:
Immunology
Macrophages are fundamental to sustain physiological equilibrium and to regulate the pathogenesis of parasitic and metabolic processes. The functional heterogeneity and immune responses of macrophages are shaped by cellular metabolism in response to
Autor:
Owen Jensen, Shubhanshi Trivedi, Jeremy D. Meier, Keke C. Fairfax, J. Scott Hale, Daniel T. Leung
Publikováno v:
Sci Immunol
Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes that aid in protection against bacterial pathogens at mucosal surfaces through the release of inflammatory cytokines and cytotoxic molecules. Recent evidence suggests MAIT cell
Publikováno v:
European Journal of Immunology. 49:428-442
IL-4 is critical for differentiation of Th2 cells and antibody isotype switching, but our work demonstrated that it is produced in the peripheral LN under both Type 2, and Type 1 conditions, raising the possibility of other functions. We found that I
Publikováno v:
The Journal of Immunology. 208:168.05-168.05
Il-4 has a critical role in organizing the peripheral lymph nodes in homeostasis and after vaccination. To further understand the molecular mechanisms and their impact in the immune response, we used single cell RNA-Seq of CD45+ cells in 4get and 4ge
Publikováno v:
The Journal of Immunology. 208:107.16-107.16
Maternal helminth infections are a global public health concern that correlate with altered infant immune responses to childhood immunizations and infection. A mechanistic understanding of how maternal infection and inflammation alters the immune res