Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Kejun Guo"'
Autor:
Nicholas Dopkins, Tongyi Fei, Stephanie Michael, Nicholas Liotta, Kejun Guo, Kaylee L. Mickens, Brad S. Barrett, Matthew L. Bendall, Stephanie M. Dillon, Cara C. Wilson, Mario L. Santiago, Douglas F. Nixon
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105133- (2024)
Summary: Background: Endogenous retroelements (EREs), including human endogenous retroviruses (HERVs) and long interspersed nuclear elements (LINEs), comprise almost half of the human genome. Our previous studies of the interferome in the gut suggest
Externí odkaz:
https://doaj.org/article/77bd4000351b463188eba2fb539d30cc
Autor:
Stephanie M. Dillon, Kaylee L. Mickens, Tezha A. Thompson, Emily H. Cooper, Sabrina Nesladek, Allison J. Christians, Moriah Castleman, Kejun Guo, Cheyret Wood, Daniel N. Frank, Katerina Kechris, Mario L. Santiago, Cara C. Wilson
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
Chronic HIV-1 infection results in the sustained disruption of gut homeostasis culminating in alterations in microbial communities (dysbiosis) and increased microbial translocation. Major questions remain on how interactions between translocating mic
Externí odkaz:
https://doaj.org/article/54b024d5ab0a42a08f2c056a33def948
Autor:
Kim J. Hasenkrug, Friederike Feldmann, Lara Myers, Mario L. Santiago, Kejun Guo, Bradley S. Barrett, Kaylee L. Mickens, Aaron Carmody, Atsushi Okumura, Deepashri Rao, Madison M. Collins, Ronald J. Messer, Jamie Lovaglio, Carl Shaia, Rebecca Rosenke, Neeltje van Doremalen, Chad Clancy, Greg Saturday, Patrick Hanley, Brian J. Smith, Kimberly Meade-White, W. Lesley Shupert, David W. Hawman, Heinz Feldmann
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Severe coronavirus disease 2019 (COVID-19) has been associated with T cell lymphopenia, but no causal effect of T cell deficiency on disease severity has been established. To investigate the specific role of T cells in recovery from severe a
Externí odkaz:
https://doaj.org/article/65f5955351984f9f865c72eabf9ac06e
Autor:
Chelsea Iwamoto, Kelsey E. Lesteberg, Molly M. Lamb, Diva M. Calvimontes, Kejun Guo, Bradley S. Barrett, Kaylee L. Mickens, Lindsey M. Duca, Jose Monzon, Anna N. Chard, Gerber Guzman, Edgar Barrios, Neudy Rojop, Kareen Arias, Melissa Gomez, Claudia Paiz, Guillermo Antonio Bolanos, Kathryn M. Edwards, Emily Zielinski Gutierrez, Eduardo Azziz-Baumgartner, Edwin J. Asturias, Mario L. Santiago, J. David Beckham, Daniel Olson
Publikováno v:
Vaccines, Vol 10, Iss 7, p 1160 (2022)
Essential agricultural workers work under occupational conditions that may increase the risk of SARS-CoV-2 exposure and transmission. Data from an agricultural worker cohort in Guatemala, and anti-SARS-CoV-2 nucleocapsid IgG (anti-N IgG) testing were
Externí odkaz:
https://doaj.org/article/b23871f242b64ce5a8d05d73c460f4fd
Autor:
Kejun Guo, Guannan Shen, Jon Kibbie, Tania Gonzalez, Stephanie M Dillon, Harry A Smith, Emily H Cooper, Kerry Lavender, Kim J Hasenkrug, Kathrin Sutter, Ulf Dittmer, Miranda Kroehl, Katerina Kechris, Cara C Wilson, Mario L Santiago
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008986 (2020)
The Type I Interferons (IFN-Is) are innate antiviral cytokines that include 12 different IFNα subtypes and IFNβ that signal through the IFN-I receptor (IFNAR), inducing hundreds of IFN-stimulated genes (ISGs) that comprise the 'interferome'. Quanti
Externí odkaz:
https://doaj.org/article/3fba1411c8544aef9e0108a9c016d94d
Autor:
Amanda Agazio, Jennifer Cimons, Kristin M. Shotts, Kejun Guo, Mario L. Santiago, Roberta Pelanda, Raul M. Torres
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Peripheral tolerance is essential for silencing weakly autoreactive B cells that have escaped central tolerance, but it is unclear why these potentially pathogenic B cells are retained rather than being eliminated entirely. Release from peripheral to
Externí odkaz:
https://doaj.org/article/3e918bf19a4a461ea7dc86464daa4711
Publikováno v:
Bio-Protocol, Vol 10, Iss 2 (2020)
Gut CD4 T cells are major targets of HIV-1 and are massively depleted early during infection. To better understand the mechanisms governing HIV-1-mediated CD4 T cell death, we developed the physiologically-relevant Lamina Propria Aggregate Culture (L
Externí odkaz:
https://doaj.org/article/073affd7f80a403b92244b2277c14067
Autor:
Bradley S. Barrett, Michael S. Harper, Sean T. Jones, Kejun Guo, Karl J. Heilman, Ross M. Kedl, Kim J. Hasenkrug, Mario L. Santiago
Publikováno v:
Retrovirology, Vol 14, Iss 1, Pp 1-9 (2017)
Abstract Background APOBEC3/Rfv3 restricts acute Friend retrovirus (FV) infection and promotes virus-specific neutralizing antibody (NAb) responses. Classical Rfv3 studies utilized FV stocks containing lactate-dehydrogenase elevating virus (LDV), a p
Externí odkaz:
https://doaj.org/article/f9497c1a868c48669f0949b9bd49aba8
Autor:
Alyson C Yoder, Kejun Guo, Stephanie M Dillon, Tzu Phang, Eric J Lee, Michael S Harper, Karen Helm, John C Kappes, Christina Ochsenbauer, Martin D McCarter, Cara C Wilson, Mario L Santiago
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006226 (2017)
Global transcriptome studies can help pinpoint key cellular pathways exploited by viruses to replicate and cause pathogenesis. Previous data showed that laboratory-adapted HIV-1 triggers significant gene expression changes in CD4+ T cell lines and mi
Externí odkaz:
https://doaj.org/article/bdac14528b3549829958bb709651c435
Autor:
Michael S Harper, Kejun Guo, Kathrin Gibbert, Eric J Lee, Stephanie M Dillon, Bradley S Barrett, Martin D McCarter, Kim J Hasenkrug, Ulf Dittmer, Cara C Wilson, Mario L Santiago
Publikováno v:
PLoS Pathogens, Vol 11, Iss 11, p e1005254 (2015)
HIV-1 is transmitted primarily across mucosal surfaces and rapidly spreads within the intestinal mucosa during acute infection. The type I interferons (IFNs) likely serve as a first line of defense, but the relative expression and antiviral propertie
Externí odkaz:
https://doaj.org/article/54141f1b123549ce850f9ddbd7ed9618